PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8184439-0 1994 Carbon tetrachloride suppresses T-cell-dependent immune responses by induction of transforming growth factor-beta 1. Carbon Tetrachloride 0-20 transforming growth factor, beta 1 Mus musculus 82-115 31575049-0 2019 Mycelium Polysaccharides from Termitomyces albuminosus Attenuate CCl4-Induced Chronic Liver Injury Via Inhibiting TGFbeta1/Smad3 and NF-kappaB Signal Pathways. Carbon Tetrachloride 65-69 transforming growth factor, beta 1 Mus musculus 114-122 32933544-0 2020 Targeting Follistatin like 1 ameliorates liver fibrosis induced by carbon tetrachloride through TGF-beta1-miR29a in mice. Carbon Tetrachloride 67-87 transforming growth factor, beta 1 Mus musculus 96-105 34191114-8 2021 Furthermore, fibrotic-related proteins TGF-beta1, pSmad2C, pSmad2L, and PAI-1 were also increased in CCl4-induced pSmad3C+/- mice. Carbon Tetrachloride 101-105 transforming growth factor, beta 1 Mus musculus 39-48 35483553-0 2022 The Mouse Anxa6/miR-9-5p/Anxa2 Axis Modulates TGF-beta1-induced Mouse Hepatic Stellate Cell (mHSC) Activation and CCl4-caused Liver Fibrosis. Carbon Tetrachloride 114-118 transforming growth factor, beta 1 Mus musculus 46-55 35240537-4 2022 Furthermore, CCl4-triggerd collagen deposition and liver fibrosis were remarkably attenuated in mice with Mul supplementation through suppressing transforming growth factor beta1 (TGF-beta1)/SMAD2/3 signaling pathway. Carbon Tetrachloride 13-17 transforming growth factor, beta 1 Mus musculus 146-178 35240537-4 2022 Furthermore, CCl4-triggerd collagen deposition and liver fibrosis were remarkably attenuated in mice with Mul supplementation through suppressing transforming growth factor beta1 (TGF-beta1)/SMAD2/3 signaling pathway. Carbon Tetrachloride 13-17 transforming growth factor, beta 1 Mus musculus 180-189 35387552-9 2022 Moreover, GZFL downregulated the expressions of TGF-beta1, p-Smad2, p-Smad3, and CUGBP1 in CCl4-treated mice. Carbon Tetrachloride 91-95 transforming growth factor, beta 1 Mus musculus 48-57 32783983-0 2020 Baihe Wuyao decoction ameliorates CCl4-induced chronic liver injury and liver fibrosis in mice through blocking TGF-beta1/Smad2/3 signaling, anti-inflammation and anti-oxidation effects. Carbon Tetrachloride 34-38 transforming growth factor, beta 1 Mus musculus 112-121 32783983-16 2020 CONCLUSION: BWD ameliorates CCl4-induced CLI and liver fibrosis which is correlated to its blocking TGF-beta1/Smad2/3 signaling, anti-inflammation, and anti-oxidation effects. Carbon Tetrachloride 28-32 transforming growth factor, beta 1 Mus musculus 100-109 31677501-0 2019 Ampelopsin attenuates carbon tetrachloride-induced mouse liver fibrosis and hepatic stellate cell activation associated with the SIRT1/TGF-beta1/Smad3 and autophagy pathway. Carbon Tetrachloride 22-42 transforming growth factor, beta 1 Mus musculus 135-144 31677501-9 2019 Conclusively, these results suggest that Amp could decrease CCl4-induced hepatic fibrosis through regulating the SIRT1/TGF-beta1/Smad3 and autophagy pathway. Carbon Tetrachloride 60-64 transforming growth factor, beta 1 Mus musculus 119-128 20162732-4 2010 We demonstrated that carbon tetrachloride (CCl(4))-induced liver fibrosis and the nuclear translocation of p-Smad2/3, the immediate downstream of transforming growth factor beta (TGF-beta), were significantly inhibited in the liver of SMP30 KO mice compared with wildtype (WT) mice. Carbon Tetrachloride 21-41 transforming growth factor, beta 1 Mus musculus 179-187 30781895-0 2019 Red Quinoa Bran Extracts Protects against Carbon Tetrachloride-Induced Liver Injury and Fibrosis in Mice via Activation of Antioxidative Enzyme Systems and Blocking TGF-beta1 Pathway. Carbon Tetrachloride 42-62 transforming growth factor, beta 1 Mus musculus 165-174 30219503-5 2018 Carbon tetrachloride induced hepatic fibrosis observed through increased inflammatory (TNF-alpha, IL-1beta, COX-2, NO and iNOS) and fibrotic markers (TGF-beta and TIMP-1), changes in the hepatic morphology, high presence of collagen fibers and elevated serum levels of AST, ALT and ALP. Carbon Tetrachloride 0-20 transforming growth factor, beta 1 Mus musculus 150-158 29490978-5 2018 Transient increases in TGF-beta1 levels and Smad2 phosphorylation signaling were observed 6 hours and 3 days, respectively, after CCl4 challenge in WT, but not PF4CreTgfb1f/f , mice, suggesting that increased TGF-beta1 levels originated from platelet-released TGF-beta1 during the initial injury. Carbon Tetrachloride 130-134 transforming growth factor, beta 1 Mus musculus 23-32 29268190-7 2018 Further investigation indicated that the possible molecular target of MGIVE is the toll-like receptor 4 (TLR4)-mediated pathway, and MGIVE treatment significantly prevented CCl4-induced transforming growth factor-beta1 (TGF-beta1) overexpression and the phosphorylation of mitogen activated protein kinase (MAPK) in vivo. Carbon Tetrachloride 173-177 transforming growth factor, beta 1 Mus musculus 220-229 28390311-0 2017 Metformin mitigates carbon tetrachloride-induced TGF-beta1/Smad3 signaling and liver fibrosis in mice. Carbon Tetrachloride 20-40 transforming growth factor, beta 1 Mus musculus 49-58 30132521-0 2018 Downregulation of Glt25d1 aggravates carbon tetrachloride-induced acute hepatic injury through activation of the TGF-beta1/Smad2 signaling pathway. Carbon Tetrachloride 37-57 transforming growth factor, beta 1 Mus musculus 113-122 28918026-8 2017 TGF-beta1/Smad ODN prevented the fibrogenesis and deposition of collagen in CCl4-treated mouse model. Carbon Tetrachloride 76-80 transforming growth factor, beta 1 Mus musculus 0-9 28279768-7 2017 In addition, PAP also significantly reversed CCl4-induced alteration of TGF-beta and p-samd-3 in liver tissue. Carbon Tetrachloride 45-49 transforming growth factor, beta 1 Mus musculus 72-80 28279768-8 2017 In conclusion, PAP restored CCl4-induced hepatotoxicity via TLR/NF-kappaB and TGF-beta/samd-3 pathways. Carbon Tetrachloride 28-32 transforming growth factor, beta 1 Mus musculus 78-86 27224286-0 2016 Involvement of TGF-beta1/Smad3 Signaling in Carbon Tetrachloride-Induced Acute Liver Injury in Mice. Carbon Tetrachloride 44-64 transforming growth factor, beta 1 Mus musculus 15-24 27186319-9 2016 Profibrotic transforming growth factor-beta1 (TGF-beta1) mRNA and expression of smooth muscle alpha-actin, an indicator of hepatic stellate cell (HSC) activation, increased markedly after CCl4 treatment. Carbon Tetrachloride 188-192 transforming growth factor, beta 1 Mus musculus 46-55 27186319-10 2016 Smad 2/3, the major mediator of TGF-beta fibrogenic effects, was also activated after CCl4 treatment. Carbon Tetrachloride 86-90 transforming growth factor, beta 1 Mus musculus 32-40 26752747-7 2016 Carbon tetrachloride treatment led to significant increases in versican expression and the proteoglycanases ADAMTS-5, -9, -15, and -20, alongside TNF-alpha, alpha-smooth muscle actin (alpha-SMA), collagen-1, and TGF-beta expression. Carbon Tetrachloride 0-20 transforming growth factor, beta 1 Mus musculus 212-220 26122378-0 2015 Xia-yu-xue decoction (XYXD) reduces carbon tetrachloride (CCl4)-induced liver fibrosis through inhibition hepatic stellate cell activation by targeting NF-kappaB and TGF-beta1 signaling pathways. Carbon Tetrachloride 36-56 transforming growth factor, beta 1 Mus musculus 166-175 25710025-8 2015 These data suggest that hepatocyte-specific ablation of PP2Acalpha protects against CCl4-induced chronic hepatic injury and fibrogenesis and the protective effect is mediated at least partially through the impaired TGF-beta1/Smad signaling. Carbon Tetrachloride 84-88 transforming growth factor, beta 1 Mus musculus 215-224 25076423-12 2014 Further, in-vivo alpha-CD147 antibody intervention decreased liver MMP-2, -9, -13, -14, TGF-beta and alpha-SMA expression in CCl4 treated mice compared to controls. Carbon Tetrachloride 125-129 transforming growth factor, beta 1 Mus musculus 88-96 20157387-0 2008 Effects of TGF-beta1 Ribbon Antisense on CCl(4)-induced Liver Fibrosis. Carbon Tetrachloride 41-47 transforming growth factor, beta 1 Mus musculus 11-20 20157387-1 2008 Ribbon-type antisense oligonucleotide to TGF-beta1 (TGF-beta1 RiAS) was designed and tested to prevent or resolve the fibrotic changes induced by CCl4 injection. Carbon Tetrachloride 146-150 transforming growth factor, beta 1 Mus musculus 41-50 20157387-1 2008 Ribbon-type antisense oligonucleotide to TGF-beta1 (TGF-beta1 RiAS) was designed and tested to prevent or resolve the fibrotic changes induced by CCl4 injection. Carbon Tetrachloride 146-150 transforming growth factor, beta 1 Mus musculus 52-61 17976157-9 2008 CCl4 administration increased the expression levels of TGF-beta1 mRNA and alpha-SMA protein, and decreased the expression of MMP-13 mRNA in livers of NK2 transgenic mice compared with those of WT mice. Carbon Tetrachloride 0-4 transforming growth factor, beta 1 Mus musculus 55-64 14724832-8 2003 RESULTS: When mice were administered carbon tetrachloride (300 microL/kg body weight) twice a week for 12 weeks, knockout mice showed extensive liver fibrosis with an enhanced expression of transforming growth factor-beta 1 and connective tissue growth factor compared with wild-type mice (P < 0.05). Carbon Tetrachloride 37-57 transforming growth factor, beta 1 Mus musculus 190-223 14636827-3 2003 We have previously demonstrated that the hepatotoxic chlorinated hydrocarbon, carbon tetrachloride, suppresses helper T-lymphocyte function in a TGF-beta(1)-dependent manner. Carbon Tetrachloride 78-98 transforming growth factor, beta 1 Mus musculus 145-156 9169066-0 1997 Induction of liver-associated transforming growth factor beta 1 (TGF-beta 1) mRNA expression by carbon tetrachloride leads to the inhibition of T helper 2 cell-associated lymphokines. Carbon Tetrachloride 96-116 transforming growth factor, beta 1 Mus musculus 30-63 9169066-0 1997 Induction of liver-associated transforming growth factor beta 1 (TGF-beta 1) mRNA expression by carbon tetrachloride leads to the inhibition of T helper 2 cell-associated lymphokines. Carbon Tetrachloride 96-116 transforming growth factor, beta 1 Mus musculus 65-75 9169066-1 1997 Acute treatment of B6C3F1 mice with a hepatotoxic dose (500 mg/kg) of carbon tetrachloride (CCl4) produced a marked but transient increase in transforming growth factor beta 1 (TGF-beta 1) mRNA expression in the liver within 24 hr. Carbon Tetrachloride 70-90 transforming growth factor, beta 1 Mus musculus 142-175 9169066-1 1997 Acute treatment of B6C3F1 mice with a hepatotoxic dose (500 mg/kg) of carbon tetrachloride (CCl4) produced a marked but transient increase in transforming growth factor beta 1 (TGF-beta 1) mRNA expression in the liver within 24 hr. Carbon Tetrachloride 70-90 transforming growth factor, beta 1 Mus musculus 177-187