PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35098926-6 2022 Finally, we demonstrate that a loss-of-function mutation in nhr-8, which alters cholesterol metabolism and is used to study conditions of sterol deficiency, causes TIR-1/SARM1 to oligomerize into puncta in intestinal epithelial cells. Sterols 138-144 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;NAD(+) hydrolase tir-1 Caenorhabditis elegans 164-169