PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29263028-8 2018 Together, our data suggest that sterol precursors are needed for Set4 induction through an Upc2-mediated mechanism. Sterols 32-38 Upc2p Saccharomyces cerevisiae S288C 91-95 26448198-0 2016 The zinc cluster proteins Upc2 and Ecm22 promote filamentation in Saccharomyces cerevisiae by sterol biosynthesis-dependent and -independent pathways. Sterols 94-100 Upc2p Saccharomyces cerevisiae S288C 26-30 26448198-4 2016 Ecm22 and Upc2 positively control the expression of FHN1, NPR1, PRR2 and sterol biosynthesis genes. Sterols 73-79 Upc2p Saccharomyces cerevisiae S288C 10-14 24453983-2 2014 However, in yeasts such as Saccharomyces cerevisiae and Candida albicans sterol synthesis is instead regulated by Upc2, an unrelated transcription factor with a Gal4-type zinc finger. Sterols 73-79 Upc2p Saccharomyces cerevisiae S288C 114-118 24867980-5 2014 We hypothesized that due to the global role for Upc2 in sterol biosynthesis in S. cerevisiae and C. albicans, disruption of UPC2A would enhance the activity of fluconazole in both azole-susceptible dose-dependent (SDD) and -resistant C. glabrata clinical isolates. Sterols 56-62 Upc2p Saccharomyces cerevisiae S288C 48-52 24453983-8 2014 RNA-seq analysis shows that hypoxic regulation of sterol synthesis genes in Y. lipolytica is predominantly mediated by Upc2. Sterols 50-56 Upc2p Saccharomyces cerevisiae S288C 119-123 22129104-8 2012 Positive inputs of two transcriptional activators Pdr1p and Upc2p were also detected, indicating a regulatory link common to sterol biosynthetic genes as well as those involved in pleiotropic drug resistance and sphingolipid metabolism. Sterols 125-131 Upc2p Saccharomyces cerevisiae S288C 60-65 23475705-4 2013 First, as previously well characterized, we observe sterol import under low oxygen levels in S. cerevisiae and C. glabrata, which is dependent on the transcription factor Upc2 and/or its orthologs or paralogs. Sterols 52-58 Upc2p Saccharomyces cerevisiae S288C 171-175 23385756-2 2013 In response to sterol levels, the transcriptional activity of Upc2 is controlled by the C-terminal domain. Sterols 15-21 Upc2p Saccharomyces cerevisiae S288C 62-66 16783004-5 2006 However, induction of both ERG genes and the hypoxically expressed DAN/TIR genes by Upc2p and Ecm22p occurred in response to sterol depletion rather than to heme depletion. Sterols 125-131 Upc2p Saccharomyces cerevisiae S288C 84-89 21199190-1 2011 Zn[2]-Cys[6] binuclear transcription factors Upc2p and Ecm22p regulate the expression of genes involved in ergosterol biosynthesis and exogenous sterol uptake in Saccharomyces cerevisiae. Sterols 111-117 Upc2p Saccharomyces cerevisiae S288C 45-50 18675371-7 2008 Nuclear localization in response to sterol depletion is consistent with the hypothesis that Upc2p and Ecm22p are trafficked from a membrane to the nucleus as a post-translational mechanism of sterol sensing. Sterols 36-42 Upc2p Saccharomyces cerevisiae S288C 92-97 18675371-7 2008 Nuclear localization in response to sterol depletion is consistent with the hypothesis that Upc2p and Ecm22p are trafficked from a membrane to the nucleus as a post-translational mechanism of sterol sensing. Sterols 192-198 Upc2p Saccharomyces cerevisiae S288C 92-97 16702413-1 2006 UPC2 and ECM22 belong to a Zn(2)-Cys(6) family of fungal transcription factors and have been implicated in the regulation of sterol synthesis in Saccharomyces cerevisiae and Candida albicans. Sterols 125-131 Upc2p Saccharomyces cerevisiae S288C 0-4 15638242-7 2004 The sterol composition of the upc2delta ecm22delta double mutant reflected regulation of the latter part of the ergosterol synthesis by the Upc2p and Ecm22p transcription factors. Sterols 4-10 Upc2p Saccharomyces cerevisiae S288C 140-145 16055745-3 2005 We have identified the transcriptional activation domains of Upc2p and Ecm22p and found that UPC2-1, a mutation that allows cells to take up sterols aerobically, increased the potency of the activation domain. Sterols 141-148 Upc2p Saccharomyces cerevisiae S288C 61-66 16055745-3 2005 We have identified the transcriptional activation domains of Upc2p and Ecm22p and found that UPC2-1, a mutation that allows cells to take up sterols aerobically, increased the potency of the activation domain. Sterols 141-148 Upc2p Saccharomyces cerevisiae S288C 93-97 16055745-5 2005 The C-terminal regions of Upc2p and Ecm22p, which contained activation domains, also conferred regulation in response to sterol levels. Sterols 121-127 Upc2p Saccharomyces cerevisiae S288C 26-31 15855491-9 2005 Importantly, the purified DNA binding domain of Upc2p bound in vitro to putative sterol response elements in the ERG2 promoter, suggesting that Upc2p increases the expression of the ERG genes by directly binding to their promoters. Sterols 81-87 Upc2p Saccharomyces cerevisiae S288C 48-53 15855491-9 2005 Importantly, the purified DNA binding domain of Upc2p bound in vitro to putative sterol response elements in the ERG2 promoter, suggesting that Upc2p increases the expression of the ERG genes by directly binding to their promoters. Sterols 81-87 Upc2p Saccharomyces cerevisiae S288C 144-149 12077145-2 2002 To identify components of non-lipoprotein-mediated sterol uptake, we utilized strains of Saccharomyces cerevisiae that accumulate exogenous sterol due to a neomorphic mutation in the transcription factor, UPC2. Sterols 51-57 Upc2p Saccharomyces cerevisiae S288C 205-209 12697649-7 2003 Cell wall maintenance genes TIR4 and CCW12, sterol metabolism gene UPC2, small molecule transport genes AUS1 and YHK8, and stress response gene CUP1-1 were expressed at a level at least 2.5-fold higher than the expression level found in 9763S. Sterols 44-50 Upc2p Saccharomyces cerevisiae S288C 67-71 12077145-2 2002 To identify components of non-lipoprotein-mediated sterol uptake, we utilized strains of Saccharomyces cerevisiae that accumulate exogenous sterol due to a neomorphic mutation in the transcription factor, UPC2. Sterols 140-146 Upc2p Saccharomyces cerevisiae S288C 205-209 12077145-4 2002 We identified 9 genes as responsive to UPC2 that were also induced under anaerobiosis, when sterol uptake is essential. Sterols 92-98 Upc2p Saccharomyces cerevisiae S288C 39-43 12077145-6 2002 UPC2 itself was up-regulated under these conditions and was required for aerobic sterol influx. Sterols 81-87 Upc2p Saccharomyces cerevisiae S288C 0-4 11533229-0 2001 Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae. Sterols 37-43 Upc2p Saccharomyces cerevisiae S288C 0-5 11533229-2 2001 We found that the paralogous transcription factors Upc2p and Ecm22p of yeast were sterol regulatory element (SRE) binding proteins (SREBPs) responsible for regulating transcription of the sterol biosynthetic genes ERG2 and ERG3. Sterols 82-88 Upc2p Saccharomyces cerevisiae S288C 51-56 11533229-6 2001 Ecm22p and Upc2p are members of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors and share no homology to the analogous proteins, SREBPs, that are responsible for transcriptional regulation by sterols in humans. Sterols 227-234 Upc2p Saccharomyces cerevisiae S288C 11-16 32564734-8 2020 The UPC2-1 mutation in the transcription factor UPC2 gene, which leads to the excessive accumulation of sterols in the cell, promotes cell survival in the presence of the pheromone and shows additivity with the LAM2 deletion. Sterols 104-111 Upc2p Saccharomyces cerevisiae S288C 4-8 11208779-0 2001 Identification of a UPC2 homolog in Saccharomyces cerevisiae and its involvement in aerobic sterol uptake. Sterols 92-98 Upc2p Saccharomyces cerevisiae S288C 20-24 11208779-2 2001 A specific mutant, upc2-1, of the predicted transcriptional activator UPC2 (YDR213w) has been recognized as a strain that allows a high level of aerobic sterol uptake. Sterols 153-159 Upc2p Saccharomyces cerevisiae S288C 19-23 11208779-2 2001 A specific mutant, upc2-1, of the predicted transcriptional activator UPC2 (YDR213w) has been recognized as a strain that allows a high level of aerobic sterol uptake. Sterols 153-159 Upc2p Saccharomyces cerevisiae S288C 70-74 11208779-8 2001 The upc2-1 point mutation responsible for aerobic sterol uptake was duplicated in the homologous carboxy region of the YLR228c ORF using site-directed mutagenesis. Sterols 50-56 Upc2p Saccharomyces cerevisiae S288C 4-8 9696767-4 1998 One of these mutations, designated upc2-1, gives a pleiotropic phenotype in characteristics as diverse as aerobic accumulation of sterols, total lipid storage, sensitivity to metabolic inhibitors, response to altered sterol structures, and cation requirements. Sterols 130-137 Upc2p Saccharomyces cerevisiae S288C 35-39 9696767-4 1998 One of these mutations, designated upc2-1, gives a pleiotropic phenotype in characteristics as diverse as aerobic accumulation of sterols, total lipid storage, sensitivity to metabolic inhibitors, response to altered sterol structures, and cation requirements. Sterols 130-136 Upc2p Saccharomyces cerevisiae S288C 35-39 9696767-5 1998 During experiments designed to ascertain the effects of various cations on yeast with sterol alterations, it was observed that upc2-1 was hypersensitive to Ca2+. Sterols 86-92 Upc2p Saccharomyces cerevisiae S288C 127-131 33161613-0 2020 UPC2 gene deletion modifies sterol homeostasis and susceptibility to metabolic inhibitors in Kluyveromyces lactis. Sterols 28-34 Upc2p Saccharomyces cerevisiae S288C 0-4 33161613-1 2020 Kluyveromyces lactis Upc2p is an ortholog of Upc2p/Ecm22p transcription factors involved in regulation of sterol import and sterol homeostasis in Saccharomyces cerevisiae. Sterols 106-112 Upc2p Saccharomyces cerevisiae S288C 21-26 33161613-1 2020 Kluyveromyces lactis Upc2p is an ortholog of Upc2p/Ecm22p transcription factors involved in regulation of sterol import and sterol homeostasis in Saccharomyces cerevisiae. Sterols 106-112 Upc2p Saccharomyces cerevisiae S288C 45-50 33161613-1 2020 Kluyveromyces lactis Upc2p is an ortholog of Upc2p/Ecm22p transcription factors involved in regulation of sterol import and sterol homeostasis in Saccharomyces cerevisiae. Sterols 124-130 Upc2p Saccharomyces cerevisiae S288C 21-26 33161613-1 2020 Kluyveromyces lactis Upc2p is an ortholog of Upc2p/Ecm22p transcription factors involved in regulation of sterol import and sterol homeostasis in Saccharomyces cerevisiae. Sterols 124-130 Upc2p Saccharomyces cerevisiae S288C 45-50 32564734-8 2020 The UPC2-1 mutation in the transcription factor UPC2 gene, which leads to the excessive accumulation of sterols in the cell, promotes cell survival in the presence of the pheromone and shows additivity with the LAM2 deletion. Sterols 104-111 Upc2p Saccharomyces cerevisiae S288C 48-52