PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22291955-0	2012	Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis.	Sterols	24-30	nuclear receptor subfamily 1 group H member 4	Homo sapiens	76-79	
12705905-2	2003	Guggulsterone, a plant sterol that lowers serum cholesterol, has been shown to antagonize FXR activated genes.	Sterols	23-29	nuclear receptor subfamily 1 group H member 4	Homo sapiens	90-93	
16460270-1	2006	Liver X receptors (LXRs) and farnesoid X receptor (FXR) are nuclear receptors that function as intracellular sensors for sterols and bile acids, respectively.	Sterols	121-128	nuclear receptor subfamily 1 group H member 4	Homo sapiens	51-54	
21309576-0	2011	Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid-X-receptor.	Sterols	22-29	nuclear receptor subfamily 1 group H member 4	Homo sapiens	104-124	
21691099-9	2011	Note that although FXR and TGR5 are thought to function primarily as bile acid receptors, they are modulated by some other sterols and select lipid metabolites, and are also widely expressed in tissues, indicating a complex interplay among diverse regulatory networks that impact critical cell and organ functions.	Sterols	123-130	nuclear receptor subfamily 1 group H member 4	Homo sapiens	19-22	
15459087-3	2004	To prevent cytotoxicity attributable to accumulation of excess cholesterol, liver X receptors (LXRs) and the farnesoid X receptor (FXR), together with other members of the nuclear receptor superfamily, promote the storage, transport, and catabolism of sterols and their metabolites.	Sterols	252-259	nuclear receptor subfamily 1 group H member 4	Homo sapiens	109-129	
15459087-3	2004	To prevent cytotoxicity attributable to accumulation of excess cholesterol, liver X receptors (LXRs) and the farnesoid X receptor (FXR), together with other members of the nuclear receptor superfamily, promote the storage, transport, and catabolism of sterols and their metabolites.	Sterols	252-259	nuclear receptor subfamily 1 group H member 4	Homo sapiens	131-134	
14770367-13	2004	The fact that intracellular sterol sensors (FXR, LXR, and SREBP1c) are involved in the control of the I-BABP gene expression strongly suggests that I-BABP exerts an important role in maintenance of cholesterol balance.	Sterols	28-34	nuclear receptor subfamily 1 group H member 4	Homo sapiens	44-47	
12021839-5	2002	This work has led to the realization that networks of nuclear hormone receptors, including the LXR, FXR, PPAR, and RXR proteins, play critical roles in lipid metabolism by virtue of their transcriptional regulation of the genes that control sterol metabolic pathways.	Sterols	241-247	nuclear receptor subfamily 1 group H member 4	Homo sapiens	100-103	
12479580-8	2002	The fact that intracellular sterol sensors (FXR, LXR and SREBP1c) are involved in the control of I-BABP gene expression strongly suggest a crucial role for I-BABP in the ileum.	Sterols	28-34	nuclear receptor subfamily 1 group H member 4	Homo sapiens	44-47	
10698678-3	2000	To investigate the potential of other sterols to activate FXR, as well as to examine relevant relationships among identified activators of FXR, the current study used a mammalian cell transcription assay to quantify and compare activation potential.	Sterols	38-45	nuclear receptor subfamily 1 group H member 4	Homo sapiens	58-61	
27904713-0	2016	Farnesoid X receptor ligand CDCA suppresses human prostate cancer cells growth by inhibiting lipid metabolism via targeting sterol response element binding protein 1.	Sterols	124-130	nuclear receptor subfamily 1 group H member 4	Homo sapiens	0-20	
34313539-2	2021	FXR has important regulatory impacts on a wide variety of metabolic pathways (such as glucose, lipid, and sterol metabolism) and has been recognized to ameliorate obesity, liver damage, cholestasis and chronic inflammatory diseases.	Sterols	106-112	nuclear receptor subfamily 1 group H member 4	Homo sapiens	0-3