PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19483279-6 2009 Further, osteocytes play an important role in phosphate metabolism, because osteocytes are important producers of FGF23, and FGF23 is upregulated in the osteocytes of Hyp mice and DMP1 knockout mice. Phosphates 46-55 dentin matrix protein 1 Mus musculus 180-184 27639037-0 2017 Extracellular Phosphate Induces the Expression of Dentin Matrix Protein 1 Through the FGF Receptor in Osteoblasts. Phosphates 14-23 dentin matrix protein 1 Mus musculus 50-73 18559986-1 2008 Autosomal recessive hypophosphatemic rickets (ARHR), which is characterized by renal phosphate wasting, aberrant regulation of 1alpha-hydroxylase activity, and rickets/osteomalacia, is caused by inactivating mutations of dentin matrix protein 1 (DMP1). Phosphates 24-33 dentin matrix protein 1 Mus musculus 221-244 18559986-1 2008 Autosomal recessive hypophosphatemic rickets (ARHR), which is characterized by renal phosphate wasting, aberrant regulation of 1alpha-hydroxylase activity, and rickets/osteomalacia, is caused by inactivating mutations of dentin matrix protein 1 (DMP1). Phosphates 24-33 dentin matrix protein 1 Mus musculus 246-250 18559986-5 2008 Dmp1(-/-) mice displayed decreased serum phosphate concentrations, inappropriately normal 1,25(OH)(2)D levels, severe rickets, and a diffuse form of osteomalacia in association with elevated Fgf23 serum levels and expression in osteocytes. Phosphates 41-50 dentin matrix protein 1 Mus musculus 0-4 18257058-3 2008 Conventional disruption of the murine Dmp1 gene results in defects in dentin in teeth and in the skeleton, including hypophosphatemic rickets, and abnormalities in phosphate homeostasis. Phosphates 121-130 dentin matrix protein 1 Mus musculus 38-42 16294270-15 2005 Dmp1 KO mice had significantly lower ionic calcium and phosphate concentrations relative to WT, whereas in the HET, values for phosphate were equivalent, and calcium values were decreased relative to WT values. Phosphates 55-64 dentin matrix protein 1 Mus musculus 0-4 31044094-6 2019 Genetic or pharmacological supplementation of DMP1 in Col4a3-/- mice prevented osteocyte apoptosis, preserved osteocyte networks, corrected bone mass, partially lowered FGF23 levels by attenuating NFAT-induced FGF23 transcription, and further increased serum phosphate. Phosphates 259-268 dentin matrix protein 1 Mus musculus 46-50 27639037-1 2017 Dentin matrix protein 1 (Dmp1) is an extracellular matrix protein involved in phosphate metabolism and biomineralization, and its expression markedly increases during the maturation of osteoblasts into osteocytes. Phosphates 78-87 dentin matrix protein 1 Mus musculus 0-23 27639037-1 2017 Dentin matrix protein 1 (Dmp1) is an extracellular matrix protein involved in phosphate metabolism and biomineralization, and its expression markedly increases during the maturation of osteoblasts into osteocytes. Phosphates 78-87 dentin matrix protein 1 Mus musculus 25-29 27639037-2 2017 We previously reported that an increased level of inorganic phosphate (Pi) in media up-regulated the expression of Dmp1 in primary osteocytes isolated from mouse bones. Phosphates 50-69 dentin matrix protein 1 Mus musculus 115-119 26634432-2 2015 Dentin matrix protein 1 (DMP1) is a highly expressed bone extracellular matrix protein that regulates both bone development and phosphate metabolism. Phosphates 128-137 dentin matrix protein 1 Mus musculus 0-23 28005411-0 2017 A Mutation in the Dmp1 Gene Alters Phosphate Responsiveness in Mice. Phosphates 35-44 dentin matrix protein 1 Mus musculus 18-22 28005411-10 2017 These data indicate that a Dmp1 mutation creates a lower set point for extracellular phosphate and maintains it through the regulation of Fgf23 cleavage and expression. Phosphates 85-94 dentin matrix protein 1 Mus musculus 27-31 27766035-10 2016 A 8-week treatment of a high phosphate diet significantly rescued the OA-like defect in Dmp1 null mice, supporting the critical role of phosphate homeostasis in maintaining the healthy joint morphology and function. Phosphates 29-38 dentin matrix protein 1 Mus musculus 88-92 27766035-10 2016 A 8-week treatment of a high phosphate diet significantly rescued the OA-like defect in Dmp1 null mice, supporting the critical role of phosphate homeostasis in maintaining the healthy joint morphology and function. Phosphates 136-145 dentin matrix protein 1 Mus musculus 88-92 27766035-12 2016 Instead, the regulation of phosphate homeostasis by DMP1 via the axis of "FGF23-renal phosphorus reabsorption" is vital for maintaining a healthy joint. Phosphates 27-36 dentin matrix protein 1 Mus musculus 52-56 26634432-2 2015 Dentin matrix protein 1 (DMP1) is a highly expressed bone extracellular matrix protein that regulates both bone development and phosphate metabolism. Phosphates 128-137 dentin matrix protein 1 Mus musculus 25-29 26276370-13 2015 Furthermore, PTH may modulate phosphate homeostasis by downregulating DMP1 expression via the cAMP/PKA pathway. Phosphates 30-39 dentin matrix protein 1 Mus musculus 70-74 26303287-1 2015 Human DMP1 mutations or Dmp1-null (KO) mice display hypophosphatemia rickets, suggesting a causative role of low phosphate (P) in development of osteomalacia. Phosphates 56-65 dentin matrix protein 1 Mus musculus 6-10 26303287-1 2015 Human DMP1 mutations or Dmp1-null (KO) mice display hypophosphatemia rickets, suggesting a causative role of low phosphate (P) in development of osteomalacia. Phosphates 56-65 dentin matrix protein 1 Mus musculus 24-28 25089825-5 2014 Fgfr1Dmp1-cKO-null mice exhibited a 50% reduction in FGF23 expression in bone and 3-fold reduction in serum FGF23 concentrations, as well as reductions in sclerostin (Sost), phosphate regulating endopeptidase on X chromosome (PHEX or Phex), matrix extracellular phosphoglycoprotein (Mepe), and Dmp1 transcripts, but had no demonstrable alterations in phosphate or vitamin D homeostasis or skeletal morphology. Phosphates 351-360 dentin matrix protein 1 Mus musculus 5-9 23939820-3 2014 Here we discuss conditions fitting under the umbrella of rickets, which traditionally referred to skeletal disease associated with vitamin D deficiency but has been more recently expanded to include newly identified factors involved in endocrine regulation of vitamin D, phosphate, and calcium, including phosphate-regulating endopeptidase homolog, X-linked, fibroblast growth factor 23, and dentin matrix protein 1. Phosphates 305-314 dentin matrix protein 1 Mus musculus 392-415 22549196-4 2012 In a murine model of ARHR, DMP1-null mice had increased fibroblast growth factor23 (FGF23) expression in osteocytes, indicating that DMP1 participates in the systemic phosphate regulation by restraining osteocytic FGF23 production. Phosphates 167-176 dentin matrix protein 1 Mus musculus 27-31 22534175-6 2012 In contrast, DMP-1 significantly affects bone mineralization and importantly controls serum phosphate levels by regulating serum FGF-23 levels, whereas DSPP does not show any systemic effects. Phosphates 92-101 dentin matrix protein 1 Mus musculus 13-18 22813642-1 2012 Dentin matrix protein 1 (DMP1) is highly expressed in odontoblasts and osteoblasts/osteocytes and plays an essential role in tooth and bone mineralization and phosphate homeostasis. Phosphates 159-168 dentin matrix protein 1 Mus musculus 0-23 22813642-1 2012 Dentin matrix protein 1 (DMP1) is highly expressed in odontoblasts and osteoblasts/osteocytes and plays an essential role in tooth and bone mineralization and phosphate homeostasis. Phosphates 159-168 dentin matrix protein 1 Mus musculus 25-29 22549196-4 2012 In a murine model of ARHR, DMP1-null mice had increased fibroblast growth factor23 (FGF23) expression in osteocytes, indicating that DMP1 participates in the systemic phosphate regulation by restraining osteocytic FGF23 production. Phosphates 167-176 dentin matrix protein 1 Mus musculus 133-137 22879941-8 2012 Discovering this novel protective role of DMP1 may have clinical relevance in protecting the cells from apoptosis in high-phosphate environments as observed in chronic kidney disease (CKD). Phosphates 122-131 dentin matrix protein 1 Mus musculus 42-46 22879941-0 2012 Protective roles of DMP1 in high phosphate homeostasis. Phosphates 33-42 dentin matrix protein 1 Mus musculus 20-24 21678127-7 2012 Furthermore, increased extracellular phosphate levels partially inhibited FGF2-induced upregulation of Dmp1 mRNA expression, suggesting a coordinated regulation of Dmp1 expression by FGF signaling and extracellular phosphate. Phosphates 37-46 dentin matrix protein 1 Mus musculus 103-107 21678127-7 2012 Furthermore, increased extracellular phosphate levels partially inhibited FGF2-induced upregulation of Dmp1 mRNA expression, suggesting a coordinated regulation of Dmp1 expression by FGF signaling and extracellular phosphate. Phosphates 37-46 dentin matrix protein 1 Mus musculus 164-168 21678127-7 2012 Furthermore, increased extracellular phosphate levels partially inhibited FGF2-induced upregulation of Dmp1 mRNA expression, suggesting a coordinated regulation of Dmp1 expression by FGF signaling and extracellular phosphate. Phosphates 215-224 dentin matrix protein 1 Mus musculus 103-107 21678127-7 2012 Furthermore, increased extracellular phosphate levels partially inhibited FGF2-induced upregulation of Dmp1 mRNA expression, suggesting a coordinated regulation of Dmp1 expression by FGF signaling and extracellular phosphate. Phosphates 215-224 dentin matrix protein 1 Mus musculus 164-168 21542006-3 2011 We showed (1) that abnormal bone remodeling in Dmp1 null mice is due to reduced osteoclast number, which is secondary to a reduced ratio of RANKL/OPG expressed by osteoclast supporting cells and (2) that osteoblast extracellular matrix mineralization, growth plate maturation, secondary ossification center formation, and osteoblast differentiation are phosphate-dependent. Phosphates 353-362 dentin matrix protein 1 Mus musculus 47-51 20734454-1 2011 Dentin matrix protein 1 (DMP-1) is a key molecule in controlling osteocyte formation and phosphate homeostasis. Phosphates 89-98 dentin matrix protein 1 Mus musculus 0-23 20734454-1 2011 Dentin matrix protein 1 (DMP-1) is a key molecule in controlling osteocyte formation and phosphate homeostasis. Phosphates 89-98 dentin matrix protein 1 Mus musculus 25-30 20734454-7 2011 These results show that the 57-kDa C-terminal fragment is the functional domain of DMP-1 that controls osteocyte maturation and phosphate metabolism. Phosphates 128-137 dentin matrix protein 1 Mus musculus 83-88 20877695-3 2010 Dentin matrix protein 1 (DMP1) is highly expressed in bone and required for phosphate homeostasis and mineralization. Phosphates 76-85 dentin matrix protein 1 Mus musculus 0-23 20877695-3 2010 Dentin matrix protein 1 (DMP1) is highly expressed in bone and required for phosphate homeostasis and mineralization. Phosphates 76-85 dentin matrix protein 1 Mus musculus 25-29