PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28127806-3	2017	EPS suppressed LPS-induced nitric oxide, prostaglandin E2 , TNF-alpha, interleukin-6 and interleukin-1beta at production and mRNA levels in LPS-induced RAW 264.7 macrophages.	eps	0-3	tumor necrosis factor	Mus musculus	60-69	
27261736-2	2016	Results revealed that EPS could significantly induce the production of nitric oxide (NO), tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta and enhance phagocytic activity in RAW 264.7 cells.	eps	22-25	tumor necrosis factor	Mus musculus	90-123	
27261736-5	2016	Furthermore, pretreatment of RAW 264.7 cells with specific inhibitors of NF-kappaB and MAPKs significantly attenuated EPS-induced TNF-alpha and IL-1beta production.	eps	118-121	tumor necrosis factor	Mus musculus	130-139	
24820155-5	2014	The partially hydrolyzed EPS stimulated RAW264.7 cells to induce considerable NO and various cytokine production such as TNF-alpha, IL-1beta, IL-6 and IL-10 via up-regulation of their mRNA expression.	eps	25-28	tumor necrosis factor	Mus musculus	121-130	
27163210-3	2016	EPS treatment increased the productions of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) levels in serum.	eps	0-3	tumor necrosis factor	Mus musculus	68-95	
27163210-3	2016	EPS treatment increased the productions of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) levels in serum.	eps	0-3	tumor necrosis factor	Mus musculus	97-106	
26917398-6	2016	Moreover, EPS could significantly enhance immune organs and stimulate the release of major cytokines TNF-alpha and INF-gamma, suggesting that EPS exhibited protective effect in immunocompromised mice.	eps	10-13	tumor necrosis factor	Mus musculus	101-110	
26917398-6	2016	Moreover, EPS could significantly enhance immune organs and stimulate the release of major cytokines TNF-alpha and INF-gamma, suggesting that EPS exhibited protective effect in immunocompromised mice.	eps	142-145	tumor necrosis factor	Mus musculus	101-110	
26951752-7	2016	EPS increased the concentrations of IL-2 and TNF-a.	eps	0-3	tumor necrosis factor	Mus musculus	45-50	
21843581-6	2011	Our results showed that EPS significantly inhibited LPS-induced pro-inflammatory mediators, such as nitric oxide (NO), prostaglandin E(2) (PGE(2)), and tumor necrosis factor-alpha (TNF-alpha), without any significant cytotoxicity.	eps	24-27	tumor necrosis factor	Mus musculus	152-179	
21843581-6	2011	Our results showed that EPS significantly inhibited LPS-induced pro-inflammatory mediators, such as nitric oxide (NO), prostaglandin E(2) (PGE(2)), and tumor necrosis factor-alpha (TNF-alpha), without any significant cytotoxicity.	eps	24-27	tumor necrosis factor	Mus musculus	181-190	
21843581-7	2011	EPS also downregulated mRNA and protein expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and TNF-alpha in LPS-induced BV2 microglia cells.	eps	0-3	tumor necrosis factor	Mus musculus	114-123	
20884069-5	2010	Furthermore, 24h pretreatment with 5 mug/ml EPS suppressed 100 ng/ml LPS-induced cell growth inhibition and release of TNF-alpha from J774A.1 cells.	eps	44-47	tumor necrosis factor	Mus musculus	119-128	
33291425-8	2020	We demonstrate here that EPS suppressed proinflammatory mediators, such as cyclooxygenase-2, interleukin-6, tumor necrosis factor-alpha, and interleukin-1beta, and downregulated the expression of an inducible nitric oxide synthase known to lead to oxidative stress.	eps	25-28	tumor necrosis factor	Mus musculus	108-135	
32442574-9	2020	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.	eps	57-60	tumor necrosis factor	Mus musculus	131-158	
32442574-9	2020	Without significant cytotoxicity on the RAW 264.7 cells, EPS stimulated the macrophage cells to produce pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), and prostaglandins (PGs) and nitric oxide (NO) via induction of COX-2 and iNOS expression, respectively, suggesting that this biopolymer potentiates an early innate immune response and can therefore be used as a new immune modulator.	eps	57-60	tumor necrosis factor	Mus musculus	160-169