PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26485709-11	2015	According to the results, trabectedin induced cytotoxicity and apoptosis at the IC50 dose, resulting in a significant increase expression of caspase-3, caspase-8, caspase-9, p53 and decrease expression of bcl-2 in dose-dependent manner.	Trabectedin	26-37	tumor protein p53	Homo sapiens	174-177	
16888811-0	2007	Extreme sensitivity to Yondelis (Trabectedin, ET-743) in low passaged sarcoma cell lines correlates with mutated p53.	Trabectedin	46-52	tumor protein p53	Homo sapiens	113-116	
11205907-9	2001	By contrast with camptothecin, these lesions persisted for several hours after drug removal and were not formed at 4 degrees C. Et743 treatment induced transient p53 elevation, dose-dependent cell cycle accumulation in G2-M and in G1- and S-phase, and inhibition of DNA synthesis.	Trabectedin	128-133	tumor protein p53	Homo sapiens	162-165	
16533604-3	2006	ET-743, a DNA minor groove binder, which blocks cell cycle progression in G2/M phase through a p53-independent apoptotic process, represents the most promising among novel compounds in STS, since recently completed phase II trials have consistently shown high survival, in spite of the relatively low incidence of major objective responses.	Trabectedin	0-6	tumor protein p53	Homo sapiens	95-98	
18393778-7	2006	Finally, another new drug, ecteinascidin (ET-743), that blocks cell cycle progression in G2/M phase through a p53-independent apoptotic mechanism, has shown important preclinical and clinical activity against a number of human solid tumors, including GIST.	Trabectedin	27-40	tumor protein p53	Homo sapiens	110-113	
18393778-7	2006	Finally, another new drug, ecteinascidin (ET-743), that blocks cell cycle progression in G2/M phase through a p53-independent apoptotic mechanism, has shown important preclinical and clinical activity against a number of human solid tumors, including GIST.	Trabectedin	42-48	tumor protein p53	Homo sapiens	110-113	
11165136-5	2001	ET-743 induced a significant increase in p53 levels in cell lines expressing wild-type (wt) (p53).	Trabectedin	0-6	tumor protein p53	Homo sapiens	41-44	
11165136-5	2001	ET-743 induced a significant increase in p53 levels in cell lines expressing wild-type (wt) (p53).	Trabectedin	0-6	tumor protein p53	Homo sapiens	93-96