PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24280420-7	2014	ATF4 activation and mTOR inhibition link two crucial regulators of the cellular stress response and cell metabolism to the effects of tetracyclines on eukaryotic cell metabolism, and may help to understand the antibiotic-independent influence of these drugs on human tissues.	Tetracyclines	134-147	activating transcription factor 4	Homo sapiens	0-4	
24280420-0	2014	Tetracyclines cause cell stress-dependent ATF4 activation and mTOR inhibition.	Tetracyclines	0-13	activating transcription factor 4	Homo sapiens	42-46	
24280420-4	2014	We observed that tetracyclines, including doxycycline and minocycline, caused enhanced expression of the liver chalone inhibin betaE in HepG2 cells, mediated by the cell stress-regulated transcription factor ATF4.	Tetracyclines	17-30	activating transcription factor 4	Homo sapiens	208-212	
34287642-6	2021	In keeping with this, pharmacological inactivation of ISR, or silencing of ATF4, rescued the antitumoral response to the tetracyclines.	Tetracyclines	121-134	activating transcription factor 4	Homo sapiens	75-79