PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9652371-6 1998 The reduction in lipopolysaccharide-stimulated nitrite accumulation produced by tetracyclines was significantly less when they were applied 6 h after lipopolysaccharide and absent 12 h after lipopolysaccharide, indicating that tetracyclines modify an early event in inducible NO synthase activation operating after mRNA transcription. Tetracyclines 80-93 nitric oxide synthase 2, inducible Mus musculus 266-287 9237641-0 1997 Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines. Tetracyclines 133-146 nitric oxide synthase 2, inducible Mus musculus 35-66 9237641-6 1997 These studies show a novel mechanism of action of tetracyclines which harbours properties to increase iNOS mRNA degradation and decrease iNOS protein expression and nitric oxide production in macrophages. Tetracyclines 50-63 nitric oxide synthase 2, inducible Mus musculus 102-106 9237641-6 1997 These studies show a novel mechanism of action of tetracyclines which harbours properties to increase iNOS mRNA degradation and decrease iNOS protein expression and nitric oxide production in macrophages. Tetracyclines 50-63 nitric oxide synthase 2, inducible Mus musculus 137-141 8980766-0 1997 Intraperitoneal injection of tetracyclines protects mice from lethal endotoxemia downregulating inducible nitric oxide synthase in various organs and cytokine and nitrate secretion in blood. Tetracyclines 29-42 nitric oxide synthase 2, inducible Mus musculus 96-127 8980766-5 1997 In mice treated with TETs a significant decrease of inducible nitric oxide synthase (iNOS) activity was observed in spleen and peritoneal cells compared with that detected in mice treated with LPS alone. Tetracyclines 21-25 nitric oxide synthase 2, inducible Mus musculus 52-83 8980766-5 1997 In mice treated with TETs a significant decrease of inducible nitric oxide synthase (iNOS) activity was observed in spleen and peritoneal cells compared with that detected in mice treated with LPS alone. Tetracyclines 21-25 nitric oxide synthase 2, inducible Mus musculus 85-89 8980766-9 1997 Altogether, these results indicate that TETs are advantageous candidates for the prophylaxis and treatment of septic shock in mice, having both antimicrobial activity and the ability to inhibit endogenous TNF-alpha, IL-1 alpha, and iNOS, hence, exerting, potent anti-inflammatory effects. Tetracyclines 40-44 nitric oxide synthase 2, inducible Mus musculus 232-236