PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8980766-5	1997	In mice treated with TETs a significant decrease of inducible nitric oxide synthase (iNOS) activity was observed in spleen and peritoneal cells compared with that detected in mice treated with LPS alone.	Tetracyclines	21-25	nitric oxide synthase 2, inducible	Mus musculus	52-83	
8980766-0	1997	Intraperitoneal injection of tetracyclines protects mice from lethal endotoxemia downregulating inducible nitric oxide synthase in various organs and cytokine and nitrate secretion in blood.	Tetracyclines	29-42	nitric oxide synthase 2, inducible	Mus musculus	96-127	
9652371-6	1998	The reduction in lipopolysaccharide-stimulated nitrite accumulation produced by tetracyclines was significantly less when they were applied 6 h after lipopolysaccharide and absent 12 h after lipopolysaccharide, indicating that tetracyclines modify an early event in inducible NO synthase activation operating after mRNA transcription.	Tetracyclines	80-93	nitric oxide synthase 2, inducible	Mus musculus	266-287	
9237641-0	1997	Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines.	Tetracyclines	133-146	nitric oxide synthase 2, inducible	Mus musculus	35-66	
9237641-6	1997	These studies show a novel mechanism of action of tetracyclines which harbours properties to increase iNOS mRNA degradation and decrease iNOS protein expression and nitric oxide production in macrophages.	Tetracyclines	50-63	nitric oxide synthase 2, inducible	Mus musculus	102-106	
9237641-6	1997	These studies show a novel mechanism of action of tetracyclines which harbours properties to increase iNOS mRNA degradation and decrease iNOS protein expression and nitric oxide production in macrophages.	Tetracyclines	50-63	nitric oxide synthase 2, inducible	Mus musculus	137-141	
8980766-5	1997	In mice treated with TETs a significant decrease of inducible nitric oxide synthase (iNOS) activity was observed in spleen and peritoneal cells compared with that detected in mice treated with LPS alone.	Tetracyclines	21-25	nitric oxide synthase 2, inducible	Mus musculus	85-89	
8980766-9	1997	Altogether, these results indicate that TETs are advantageous candidates for the prophylaxis and treatment of septic shock in mice, having both antimicrobial activity and the ability to inhibit endogenous TNF-alpha, IL-1 alpha, and iNOS, hence, exerting, potent anti-inflammatory effects.	Tetracyclines	40-44	nitric oxide synthase 2, inducible	Mus musculus	232-236