PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26313911-0 2015 alpha-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway. alpha-solanine 0-14 mechanistic target of rapamycin kinase Homo sapiens 119-123 26313911-10 2015 Moreover, we found downregulation of phosphorylated Akt (Thr308 and Ser473), mammalian target of rapamycin (mTOR; Ser2448 and Ser2481) and 4E-BP1 (Thr37/46) by alpha-solanine implying suppression of the Akt/mTOR pathway. alpha-solanine 160-174 mechanistic target of rapamycin kinase Homo sapiens 77-106 26313911-11 2015 Collectively, our results signify that alpha-solanine induces autophagy to exert anti-proliferative activity by triggering ER stress and inhibiting Akt/mTOR signaling pathway. alpha-solanine 39-53 mechanistic target of rapamycin kinase Homo sapiens 152-156