PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20504373-0 2010 Vaticanol C, a resveratrol tetramer, activates PPARalpha and PPARbeta/delta in vitro and in vivo. vaticanol C 0-11 peroxisome proliferator activated receptor alpha Mus musculus 47-56 20504373-7 2010 RESULTS: We show that vaticanol C activates PPARalpha and PPARbeta/delta in cell-based reporter assays, but does not activate SIRT1. vaticanol C 22-33 peroxisome proliferator activated receptor alpha Mus musculus 44-53 20504373-9 2010 Eight-week intake of vaticanol C with a high fat diet upregulates hepatic expression of PPARalpha-responsive genes such as cyp4a10, cyp4a14 and FABP1, and skeletal muscle expression of PPARbeta/delta-responsive genes, such as UCP3 and PDK4 (pyruvate dehydrogenase kinase, isoform 4), in wild-type, but not PPARalpha-knockout mice. vaticanol C 21-32 peroxisome proliferator activated receptor alpha Mus musculus 88-97 20504373-9 2010 Eight-week intake of vaticanol C with a high fat diet upregulates hepatic expression of PPARalpha-responsive genes such as cyp4a10, cyp4a14 and FABP1, and skeletal muscle expression of PPARbeta/delta-responsive genes, such as UCP3 and PDK4 (pyruvate dehydrogenase kinase, isoform 4), in wild-type, but not PPARalpha-knockout mice. vaticanol C 21-32 peroxisome proliferator activated receptor alpha Mus musculus 306-315 20504373-10 2010 CONCLUSION: Vaticanol C, a resveratrol tetramer, activated PPARalpha and PPARbeta/delta in vitro and in vivo. vaticanol C 12-23 peroxisome proliferator activated receptor alpha Mus musculus 59-68 20504373-11 2010 These findings indicate that activation of PPARalpha and PPARbeta/delta by vaticanol C may be a novel mechanism, affording beneficial effects against lifestyle-related diseases. vaticanol C 75-86 peroxisome proliferator activated receptor alpha Mus musculus 43-52