PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25651822-8	2015	Similarly, treatment with YM-58483 after the onset of CIA: (i) reversed the clinical scores; (ii) reduced paw oedema; (iii) attenuated mechanical and thermal hypersensitivity; (iv) improved spontaneous motor activity; (v) decreased periphery production of IL-1beta, IL-6 and TNF-alpha; and (vi) reduced spinal activation of ERK and calmodulin-dependent PKII (CaMKIIalpha).	4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide	26-34	mitogen-activated protein kinase 1	Mus musculus	324-327