PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28720903-1	2017	Converging lines of behavioral, electrophysiological, and biochemical evidence suggest that 5-HT2C receptor signaling may bidirectionally influence reward-related behavior through an interaction with the mesolimbic dopamine (DA) system.	Dopamine	215-223	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	92-107	
28720903-1	2017	Converging lines of behavioral, electrophysiological, and biochemical evidence suggest that 5-HT2C receptor signaling may bidirectionally influence reward-related behavior through an interaction with the mesolimbic dopamine (DA) system.	Dopamine	225-227	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	92-107	
28294132-3	2017	Recent evidence suggests that 5-HT2C receptors may be a promising target for schizophrenia since their activation reduces mesolimbic nigrostriatal dopamine release (which conveys antipsychotic action), they are expressed almost exclusively in CNS, and have weight-loss-promoting capabilities.	Dopamine	147-155	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	30-36	
23103406-1	2013	Previous studies have identified an inhibitory regulatory role of the 5-HT(2C) receptor in serotonin and dopamine neurotransmission.	Dopamine	105-113	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	70-87	
27516377-2	2017	METHODS: We combined neuroanatomic, pharmacologic, electrophysiological, Cre-lox, and chemogenetic approaches to investigate the functions of 5-hydroxytryptamine (5-HT) 2C receptor (5-HT2CR) expressed by dopamine (DA) neurons in the regulation of binge-like eating behavior in mice.	Dopamine	204-212	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	142-180	
23303047-6	2013	Extracellular dopamine concentrations were elevated in the NAc of 2CKO mice during task performance, indicating that 5-HT2C receptors impact dopamine homeostasis during a visuospatial attention task.	Dopamine	14-22	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	117-123	
23303047-6	2013	Extracellular dopamine concentrations were elevated in the NAc of 2CKO mice during task performance, indicating that 5-HT2C receptors impact dopamine homeostasis during a visuospatial attention task.	Dopamine	141-149	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	117-123	
21658435-2	2011	In the nucleus accumbens (NAc), an afferent region of the mesolimbic pathway, dopamine (DA) release can be modulated by serotonergic 2C receptors (5-HT2CR).	Dopamine	78-86	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	147-154	
21658435-2	2011	In the nucleus accumbens (NAc), an afferent region of the mesolimbic pathway, dopamine (DA) release can be modulated by serotonergic 2C receptors (5-HT2CR).	Dopamine	88-90	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	147-154	
12427861-7	2002	These findings strongly implicate 5-HT2C receptors in the serotonergic suppression of DA-mediated behavioral responses to cocaine and as a potential therapeutic target for cocaine abuse.	Dopamine	86-88	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	34-40	
21118683-0	2011	5-HT(2A) and 5-HT(2C) receptor stimulation are differentially involved in the cortical dopamine efflux-Studied in 5-HT(2A) and 5-HT(2C) genetic mutant mice.	Dopamine	87-95	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	13-30	
20624416-11	2010	Because the 5-HT(2C) receptor exerts a modulatory effect on dopamine function, the differential effects of reduced 5-HT(2C) receptor mediated transmission on responding for food versus cocaine may relate to a differential role of this neurotransmitter in mediating these two behaviours.	Dopamine	60-68	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	12-29	
19553455-5	2009	5-HT(2C)R mutant mice displayed increased activity of substantia nigra pars compacta (SNc) dopaminergic neurons, elevated baseline extracellular dopamine concentrations in the dorsal striatum (DSt), alterations in grooming behavior, and enhanced sensitivity to the stereotypic behavioral effects of d-amphetamine and GBR 12909.	Dopamine	91-99	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	0-7	
21118683-5	2011	These results provide new evidence that 5-HT(2A) receptor stimulation enhances and 5-HT(2C) receptor stimulation inhibits cortical dopamine efflux, and suggest the effects of DOI, MK-212 and mCPP on the cortical dopamine efflux are due to their different abilities on 5-HT(2A) and 5-HT(2C) receptors stimulation.	Dopamine	131-139	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	83-100