PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27452719-3 2016 Serotonin and norepinephrine transporters (SERT and NET, respectively) have affinity for dopamine uptake especially when dopamine transporters (DAT) are scant. Dopamine 89-97 solute carrier family 6 member 4 Rattus norvegicus 43-47 34143529-9 2021 Finally, increased expression levels of 5-HT1B receptors, 5-HT2C receptors, 5-HT3A receptors, 5-HT3B receptors, 5-HT6 receptors, 5-HT7 receptors, and glycosylated dopamine transporters (DATs) were found in the female SERT KO rats. Dopamine 163-171 solute carrier family 6 member 4 Rattus norvegicus 217-221 32382785-1 2020 RATIONALE: Synaptic neurotransmission with dopamine (DA), norepinephrine (NE), and serotonin (5-HT) is terminated primarily by reuptake into presynaptic terminals via the DA, NE, and 5-HT transporters (DAT/NET/SERT, respectively). Dopamine 43-51 solute carrier family 6 member 4 Rattus norvegicus 210-214 32382785-1 2020 RATIONALE: Synaptic neurotransmission with dopamine (DA), norepinephrine (NE), and serotonin (5-HT) is terminated primarily by reuptake into presynaptic terminals via the DA, NE, and 5-HT transporters (DAT/NET/SERT, respectively). Dopamine 53-55 solute carrier family 6 member 4 Rattus norvegicus 210-214 32382785-1 2020 RATIONALE: Synaptic neurotransmission with dopamine (DA), norepinephrine (NE), and serotonin (5-HT) is terminated primarily by reuptake into presynaptic terminals via the DA, NE, and 5-HT transporters (DAT/NET/SERT, respectively). Dopamine 171-173 solute carrier family 6 member 4 Rattus norvegicus 210-214 31535286-1 2019 BACKGROUND: Methamphetamine (METH)-associated alterations in the striatal dopamine (DA) system or dopamine transport (DAT) have been identified in clinical and preclinical studies with positron emission tomography (PET) imaging but have not been well correlated with in vivo serotonin transporter (SERT) availability due to the lack of appropriate imaging agents to assess SERTs. Dopamine 74-82 solute carrier family 6 member 4 Rattus norvegicus 275-296 31535286-1 2019 BACKGROUND: Methamphetamine (METH)-associated alterations in the striatal dopamine (DA) system or dopamine transport (DAT) have been identified in clinical and preclinical studies with positron emission tomography (PET) imaging but have not been well correlated with in vivo serotonin transporter (SERT) availability due to the lack of appropriate imaging agents to assess SERTs. Dopamine 74-82 solute carrier family 6 member 4 Rattus norvegicus 298-302 31535286-1 2019 BACKGROUND: Methamphetamine (METH)-associated alterations in the striatal dopamine (DA) system or dopamine transport (DAT) have been identified in clinical and preclinical studies with positron emission tomography (PET) imaging but have not been well correlated with in vivo serotonin transporter (SERT) availability due to the lack of appropriate imaging agents to assess SERTs. Dopamine 84-86 solute carrier family 6 member 4 Rattus norvegicus 275-296 31535286-1 2019 BACKGROUND: Methamphetamine (METH)-associated alterations in the striatal dopamine (DA) system or dopamine transport (DAT) have been identified in clinical and preclinical studies with positron emission tomography (PET) imaging but have not been well correlated with in vivo serotonin transporter (SERT) availability due to the lack of appropriate imaging agents to assess SERTs. Dopamine 84-86 solute carrier family 6 member 4 Rattus norvegicus 298-302 30232529-1 2019 RATIONALE: Synthetic cathinones constitute a class of abused drugs that can act at dopamine, norepinephrine, and serotonin transporters (DAT, NET, and SERT, respectively). Dopamine 83-91 solute carrier family 6 member 4 Rattus norvegicus 151-155 29697951-1 2018 4-Methylamphetamine (4-MA) is an emerging drug of abuse that acts as a substrate at plasma membrane transporters for dopamine (DAT), norepinephrine (NET), and serotonin (SERT), thereby causing nonexocytotic release of monoamine transmitters via reverse transport. Dopamine 117-125 solute carrier family 6 member 4 Rattus norvegicus 170-174 27391165-1 2016 BACKGROUND AND PURPOSE: 4-Methyl-N-methylcathinone (mephedrone) is a synthetic stimulant that acts as a substrate-type releaser at transporters for dopamine (DAT), noradrenaline (NET) and 5-HT (SERT). Dopamine 148-156 solute carrier family 6 member 4 Rattus norvegicus 194-198 21584867-13 2011 These results indicate that SERT inhibition can activate microglia and alter the regulation of TH, the rate limiting enzyme for dopamine biosynthesis. Dopamine 128-136 solute carrier family 6 member 4 Rattus norvegicus 28-32 26347626-5 2015 Modafinil was binding to the DAT but insignificantly to SERT or NET and dopamine reuptake was blocked specifically (IC50 = 11.11 muM; SERT 1547 muM; NET 182 muM). Dopamine 72-80 solute carrier family 6 member 4 Rattus norvegicus 134-138 24067924-9 2014 Neurochemical analysis of striatal tissue indicated that a 3 week SERT blockade increased DA levels in L-DOPA-treated rats. Dopamine 90-92 solute carrier family 6 member 4 Rattus norvegicus 66-70 23022052-2 2012 Their interaction with the dopamine and serotonin transporters (DAT and SERT, respectively) was evaluated through binding experiments. Dopamine 27-35 solute carrier family 6 member 4 Rattus norvegicus 72-76 22762478-3 2012 Although most studies have focused on serotonin 5-HT(1) receptor stimulation as an antidyskinetic strategy, targeting the serotonin transporter modulation of dopamine activity has been overlooked. Dopamine 159-167 solute carrier family 6 member 4 Rattus norvegicus 123-144 20004658-5 2010 These data suggest that the sensitivity of dopamine and noradrenalin receptors is changed in serotonin transporter knockout rats. Dopamine 43-51 solute carrier family 6 member 4 Rattus norvegicus 93-114 21525301-0 2011 Dopamine transport by the serotonin transporter: a mechanistically distinct mode of substrate translocation. Dopamine 0-8 solute carrier family 6 member 4 Rattus norvegicus 26-47 21525301-6 2011 To establish the physiological relevance of this mechanism for DA clearance, we show using in vivo high-speed chronoamperometry that SERT has the capacity to clear extracellularly applied DA in the hippocampal CA3 region of anesthetized rats. Dopamine 63-65 solute carrier family 6 member 4 Rattus norvegicus 133-137 21525301-6 2011 To establish the physiological relevance of this mechanism for DA clearance, we show using in vivo high-speed chronoamperometry that SERT has the capacity to clear extracellularly applied DA in the hippocampal CA3 region of anesthetized rats. Dopamine 188-190 solute carrier family 6 member 4 Rattus norvegicus 133-137 21256578-4 2011 DA-8031 exhibits high affinity and selectivity to the serotonin transporter (Ki value 1.94 nM for 5-hydroxytryptamine transporter, 22 020 nM for norepinephrine transporter, and 77 679 nM for dopamine transporter) and potency to inhibit serotonin reuptake into the rat brain synaptosome in vitro (half maximal inhibitory concentration 6.52 nM for 5-hydroxytryptamine, 30.2 muM for norepinephrine, and 136.9 muM for dopamine). Dopamine 191-199 solute carrier family 6 member 4 Rattus norvegicus 54-75 21074589-4 2011 The aim of the present study was to investigate and compare the effects of MDMA and its metabolite alpha-methyldopamine (MeDA) on several molecular targets, mainly the dopamine and serotonin transporter functionality, to provide evidence for the role of this metabolite in the neurotoxicity of MDMA in rodents. Dopamine 111-119 solute carrier family 6 member 4 Rattus norvegicus 181-202 15219271-8 2004 Furthermore, binding of [(11)C]AFM in SERT-rich regions was blocked by the cold compound AFM and the selective serotonin reuptake inhibitor citalopram but not by the selective norepinephrine reuptake inhibitor nisoxetine or the selective dopamine reuptake inhibitor GBR 12935. Dopamine 238-246 solute carrier family 6 member 4 Rattus norvegicus 38-42 19338744-1 2009 The serotonin transporter is a member of the monoamine transporter family that also includes transporters of dopamine and norepinephrine. Dopamine 109-117 solute carrier family 6 member 4 Rattus norvegicus 4-25 16636898-8 2006 Radioligand binding to the dopamine (DAT), norepinephrine (NET), and serotonin (SERT) transporters is inhibited with k (i) values of 222, 1030, and 740 nM, respectively. Dopamine 27-35 solute carrier family 6 member 4 Rattus norvegicus 80-84 11054690-0 2000 Ultrastructural localization of the serotonin transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to dopamine terminals. Dopamine 160-168 solute carrier family 6 member 4 Rattus norvegicus 36-57 11054690-1 2000 Dopamine levels within the prefrontal cortex (PFC) can be manipulated by selective inhibitors of the serotonin transporter (SERT). Dopamine 0-8 solute carrier family 6 member 4 Rattus norvegicus 101-122 11054690-1 2000 Dopamine levels within the prefrontal cortex (PFC) can be manipulated by selective inhibitors of the serotonin transporter (SERT). Dopamine 0-8 solute carrier family 6 member 4 Rattus norvegicus 124-128 1948036-3 1991 The 5HT transporter has significant homology to the gamma-aminobutyric acid, dopamine, and norepinephrine transporters. Dopamine 77-85 solute carrier family 6 member 4 Rattus norvegicus 4-19 10987842-5 2000 A role for dopamine (DA) was suggested by findings that pretreatment with the tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine, the D1 antagonist SCH-23390, or the D2 antagonist eticlopride attenuated the METH-induced decrease in striatal, but not hippocampal, SERT activity. Dopamine 21-23 solute carrier family 6 member 4 Rattus norvegicus 267-271 10436197-5 1999 In vitro binding study showed that IDAM displayed an excellent affinity to SERT sites (K(i)=0.097 nM, using membrane preparations of LLC-PK(1) cells expressing the specific transporter) and showed more than 1000-fold of selectivity for SERT over norepinehrine and dopamine (expressed in the same LLC-PK(1) cells). Dopamine 264-272 solute carrier family 6 member 4 Rattus norvegicus 75-79