PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31359186-0 2019 Immobilization of tyrosinase on Fe3o4@Au core-shell nanoparticles as bio-probe for detection of dopamine, phenol and catechol. Dopamine 96-104 tyrosinase Homo sapiens 18-28 31359186-1 2019 An optical bio-probe based on the immobilized tyrosinase on the surface of Fe3O4@Au was described for the detection of dopamine, phenol and catechol. Dopamine 119-127 tyrosinase Homo sapiens 46-56 31420727-0 2019 Correction to: Immobilization of tyrosinase on Fe3o4@Au core-shell nanoparticles as bio-probe for detection of dopamine, phenol and catechol. Dopamine 111-119 tyrosinase Homo sapiens 33-43 31432267-0 2019 A dual-channel ratiometric fluorescent probe for determination of the activity of tyrosinase using nitrogen-doped graphene quantum dots and dopamine-modified CdTe quantum dots. Dopamine 140-148 tyrosinase Homo sapiens 82-92 31432267-4 2019 The dopamine on the rQDs is catalytically oxidized by TYR to form dopamine quinone, and this leads to a reduction of the intensity of red fluorescence (peaking at 644 nm). Dopamine 4-12 tyrosinase Homo sapiens 54-57 31297616-5 2019 Tyrosinase catalyzes the oxidation of dopamine to form dopaquinone which reduces the fluorescence of the N-GQDs through a dynamic quenching process. Dopamine 38-46 tyrosinase Homo sapiens 0-10 31161325-0 2019 A tyrosinase-induced fluorescence immunoassay for detection of tau protein using dopamine-functionalized CuInS2/ZnS quantum dots. Dopamine 81-89 tyrosinase Homo sapiens 2-12 31161325-2 2019 In this work, we developed a novel tyrosinase (TYR)-induced tau aptamer-tau-tau antibody (anti-tau) sandwich fluorescence immunoassay to detect tau protein that used dopamine (DA)-functionalized CuInS2/ZnS quantum dots as the fluorophore. Dopamine 166-174 tyrosinase Homo sapiens 35-45 31161325-2 2019 In this work, we developed a novel tyrosinase (TYR)-induced tau aptamer-tau-tau antibody (anti-tau) sandwich fluorescence immunoassay to detect tau protein that used dopamine (DA)-functionalized CuInS2/ZnS quantum dots as the fluorophore. Dopamine 166-174 tyrosinase Homo sapiens 47-50 31161325-2 2019 In this work, we developed a novel tyrosinase (TYR)-induced tau aptamer-tau-tau antibody (anti-tau) sandwich fluorescence immunoassay to detect tau protein that used dopamine (DA)-functionalized CuInS2/ZnS quantum dots as the fluorophore. Dopamine 176-178 tyrosinase Homo sapiens 35-45 31161325-2 2019 In this work, we developed a novel tyrosinase (TYR)-induced tau aptamer-tau-tau antibody (anti-tau) sandwich fluorescence immunoassay to detect tau protein that used dopamine (DA)-functionalized CuInS2/ZnS quantum dots as the fluorophore. Dopamine 176-178 tyrosinase Homo sapiens 47-50 31161325-5 2019 When DA-functionalized CuInS2/ZnS quantum dots were added to the sandwich system, TYR catalyzed the transformation of DA to dopamine quinone, which acted as an effective electron acceptor and triggered fluorescence quenching. Dopamine 5-7 tyrosinase Homo sapiens 82-85 30411752-0 2019 A conjugated carbon-dot-tyrosinase bioprobe for highly selective and sensitive detection of dopamine. Dopamine 92-100 tyrosinase Homo sapiens 24-34 30771911-4 2019 Inspired by the changes in both of the solution color and the fluorescence emission due to the sensing between Si NPs and dopamine (DA), we employed tyramine as the model substrate, which can transfer into DA by tyrosinase. Dopamine 122-130 tyrosinase Homo sapiens 212-222 30771911-4 2019 Inspired by the changes in both of the solution color and the fluorescence emission due to the sensing between Si NPs and dopamine (DA), we employed tyramine as the model substrate, which can transfer into DA by tyrosinase. Dopamine 132-134 tyrosinase Homo sapiens 212-222 30771911-4 2019 Inspired by the changes in both of the solution color and the fluorescence emission due to the sensing between Si NPs and dopamine (DA), we employed tyramine as the model substrate, which can transfer into DA by tyrosinase. Dopamine 206-208 tyrosinase Homo sapiens 212-222 30625605-2 2019 Herein, a tyrosinase-mediated photoinduced electron transfer system was constructed for OPs analysis by using dopamine-functionalized upconversion nanoparticles (UCNPs) as fluorescent (FL) sensors. Dopamine 110-118 tyrosinase Homo sapiens 10-20 30625605-3 2019 Dopamine quinone was produced by tyrosinase-mediated oxidation of dopamine on the surface of UCNPs, which acted as electron accepter to quench the FL emission of UCNPs. Dopamine 66-74 tyrosinase Homo sapiens 33-43 30411752-1 2019 In this work, a bioprobe for the detection of dopamine was designed and fabricated through covalently linking fluorescent carbon dots (CDs) and tyrosinase (TYR). Dopamine 46-54 tyrosinase Homo sapiens 144-154 30411752-1 2019 In this work, a bioprobe for the detection of dopamine was designed and fabricated through covalently linking fluorescent carbon dots (CDs) and tyrosinase (TYR). Dopamine 46-54 tyrosinase Homo sapiens 156-159 30411752-2 2019 The bioprobe (named CDs-TYR) can catalyze oxidation of dopamine and produce dopaquinone, and consequently the fluorescence of the CDs was quenched due to an efficient electron transfer mechanism from excited CDs to dopaquinone. Dopamine 55-63 tyrosinase Homo sapiens 24-27 30411752-5 2019 Additionally, excellent selectivity of the bioprobe to dopamine was achieved because of the specific catalytic character of the conjugated TYR. Dopamine 55-63 tyrosinase Homo sapiens 139-142 30283922-3 2018 DA was easily oxidized to DA quinone under the catalysis of TYR by dissolved O2, which effectively quenched the fluorescence of the QDs. Dopamine 0-2 tyrosinase Homo sapiens 60-63 29869928-1 2018 In this paper a simple electrochemical sensing of dopamine by a new effective immobilization of tyrosinase (Tyr) enzyme on eggshell membrane (ESM) along with silver nanoparticles (AgNPs) is reported. Dopamine 50-58 tyrosinase Homo sapiens 96-106 29800522-2 2018 Inspired by the fluorogenic and chromogenic reaction between dopamine and resorcinol, and the specific catalytic properties of alkaline phosphatase (ALP) and tyrosinase, we designed and synthesized an unconventional substrate of ALP, named p-aminoethyl-phenyl phosphate disodium salt (PAPP). Dopamine 61-69 tyrosinase Homo sapiens 158-168 29800522-3 2018 As expected, the ALP and tyrosinase-incubated PAPP solution exhibited pale yellow with intense blue fluorescence upon addition of resorcinol, owing to the ALP-catalyzed transformation of PAPP into an intermediate tyramine, and the tyrosinase-catalyzed hydroxylation of tyramine to dopamine, as well as the specific reaction between dopamine and resorcinol. Dopamine 281-289 tyrosinase Homo sapiens 25-35 29800522-3 2018 As expected, the ALP and tyrosinase-incubated PAPP solution exhibited pale yellow with intense blue fluorescence upon addition of resorcinol, owing to the ALP-catalyzed transformation of PAPP into an intermediate tyramine, and the tyrosinase-catalyzed hydroxylation of tyramine to dopamine, as well as the specific reaction between dopamine and resorcinol. Dopamine 332-340 tyrosinase Homo sapiens 25-35 29190472-6 2018 Subsequently, this DECDs-AuNPs platform is further taken advantage to assess TYR activity by the aid of TYR"s capability for oxidation of DA into dopaquinone, which will not induce the agglomeration of AuNPs, so the fluorescence quenching of DECDs is associated with TYR activity. Dopamine 138-140 tyrosinase Homo sapiens 77-80 29190472-6 2018 Subsequently, this DECDs-AuNPs platform is further taken advantage to assess TYR activity by the aid of TYR"s capability for oxidation of DA into dopaquinone, which will not induce the agglomeration of AuNPs, so the fluorescence quenching of DECDs is associated with TYR activity. Dopamine 138-140 tyrosinase Homo sapiens 104-107 29190472-6 2018 Subsequently, this DECDs-AuNPs platform is further taken advantage to assess TYR activity by the aid of TYR"s capability for oxidation of DA into dopaquinone, which will not induce the agglomeration of AuNPs, so the fluorescence quenching of DECDs is associated with TYR activity. Dopamine 138-140 tyrosinase Homo sapiens 104-107 29869928-1 2018 In this paper a simple electrochemical sensing of dopamine by a new effective immobilization of tyrosinase (Tyr) enzyme on eggshell membrane (ESM) along with silver nanoparticles (AgNPs) is reported. Dopamine 50-58 tyrosinase Homo sapiens 108-111 29126486-0 2017 Functionalized carbon quantum dots with dopamine for tyrosinase activity analysis. Dopamine 40-48 tyrosinase Homo sapiens 53-63 29126486-3 2017 In this work, a facile fluorescent assay for TYR activity based on dopamine functionalized carbon quantum dots (CQDs-Dopa) has been developed. Dopamine 67-75 tyrosinase Homo sapiens 45-48 29126486-3 2017 In this work, a facile fluorescent assay for TYR activity based on dopamine functionalized carbon quantum dots (CQDs-Dopa) has been developed. Dopamine 117-121 tyrosinase Homo sapiens 45-48 29126486-5 2017 When TYR was mixed with CODs-Dopa, the dopamine moiety in CQDs-Dopa conjugate was oxidized to O-dopaquinone, and an intra-particle photo-induced electron transfer (PET) process consequently occurred between CQDs and O-dopaquinone to quench the fluorescence of CQDs-Dopa. Dopamine 39-47 tyrosinase Homo sapiens 5-8 29126486-5 2017 When TYR was mixed with CODs-Dopa, the dopamine moiety in CQDs-Dopa conjugate was oxidized to O-dopaquinone, and an intra-particle photo-induced electron transfer (PET) process consequently occurred between CQDs and O-dopaquinone to quench the fluorescence of CQDs-Dopa. Dopamine 29-33 tyrosinase Homo sapiens 5-8 29126486-5 2017 When TYR was mixed with CODs-Dopa, the dopamine moiety in CQDs-Dopa conjugate was oxidized to O-dopaquinone, and an intra-particle photo-induced electron transfer (PET) process consequently occurred between CQDs and O-dopaquinone to quench the fluorescence of CQDs-Dopa. Dopamine 63-67 tyrosinase Homo sapiens 5-8 29126486-6 2017 TYR activity can be determined based on the fluorescence quenching degree of CQDs-Dopa. Dopamine 82-86 tyrosinase Homo sapiens 0-3 28891289-3 2017 By employing commercially available tyramine as the model substrate (dopamine as the product), it is found that the tyrosinase-incubated tyramine solution exhibits obvious pale yellow with intense blue fluorescence in the presence of resorcinol and O2, where the absorbance and fluorescence intensity are directly related to the concentration of added tyrosinase (i.e., the amount of conversion of tyramine to dopamine). Dopamine 69-77 tyrosinase Homo sapiens 116-126 28842016-4 2017 However, in the presence of TYR, DA could be oxidized to dopaquinone, which inhibited the reduction of oxTMB by DA, resulting in a blue color recovery and an increase of the absorbance at 652nm. Dopamine 33-35 tyrosinase Homo sapiens 28-31 28842016-4 2017 However, in the presence of TYR, DA could be oxidized to dopaquinone, which inhibited the reduction of oxTMB by DA, resulting in a blue color recovery and an increase of the absorbance at 652nm. Dopamine 112-114 tyrosinase Homo sapiens 28-31 28891289-3 2017 By employing commercially available tyramine as the model substrate (dopamine as the product), it is found that the tyrosinase-incubated tyramine solution exhibits obvious pale yellow with intense blue fluorescence in the presence of resorcinol and O2, where the absorbance and fluorescence intensity are directly related to the concentration of added tyrosinase (i.e., the amount of conversion of tyramine to dopamine). Dopamine 69-77 tyrosinase Homo sapiens 352-362 28891289-3 2017 By employing commercially available tyramine as the model substrate (dopamine as the product), it is found that the tyrosinase-incubated tyramine solution exhibits obvious pale yellow with intense blue fluorescence in the presence of resorcinol and O2, where the absorbance and fluorescence intensity are directly related to the concentration of added tyrosinase (i.e., the amount of conversion of tyramine to dopamine). Dopamine 410-418 tyrosinase Homo sapiens 116-126 27448544-2 2016 Herein we report a convenient and highly sensitive fluorometric biosensor for tyrosinase activity detection based on biocompatible dopamine-functionalized Au/Ag nanoclusters (Dopa-Au/Ag NCs). Dopamine 131-139 tyrosinase Homo sapiens 78-88 28590453-0 2017 Tyrosinase-Based Biosensors for Selective Dopamine Detection. Dopamine 42-50 tyrosinase Homo sapiens 0-10 28590453-1 2017 A novel tyrosinase-based biosensor was developed for the detection of dopamine (DA). Dopamine 70-78 tyrosinase Homo sapiens 8-18 28590453-1 2017 A novel tyrosinase-based biosensor was developed for the detection of dopamine (DA). Dopamine 80-82 tyrosinase Homo sapiens 8-18 27448544-4 2016 Dopamine is readily oxidized by molecular oxygen under the catalysis of tyrosinase. Dopamine 0-8 tyrosinase Homo sapiens 72-82 27640074-7 2016 Tyrosinase, encoded by TYR, is the rate-limiting enzyme for the production of neuromelanin, and has a role in the production of dopamine. Dopamine 128-136 tyrosinase Homo sapiens 0-10 25846058-4 2015 Moreover, the reaction of TYR and DA gave rise to an emission band at 400 nm, which increased in a TYR/DA-concentration-dependent manner. Dopamine 34-36 tyrosinase Homo sapiens 26-29 26440479-0 2015 Functionalized Carbon Quantum Dots with Dopamine for Tyrosinase Activity Monitoring and Inhibitor Screening: In Vitro and Intracellular Investigation. Dopamine 40-48 tyrosinase Homo sapiens 53-63 26440479-2 2015 In this work, we develop a convenient and real-time assay with high sensitivity for TYR activity/level monitoring and its inhibitor screening based on biocompatible dopamine functionalized carbon quantum dots (Dopa-CQDs). Dopamine 165-173 tyrosinase Homo sapiens 84-87 26440479-4 2015 When the dopamine moiety in Dopa-CQDs conjugate was oxidized to a dopaquinone derivative under specific catalysis of TYR, an intraparticle photoinduced electron transfer (PET) process between CQDs and dopaquinone moiety took place, and then the fluorescence of the conjugate could be quenched simultaneously. Dopamine 9-17 tyrosinase Homo sapiens 117-120 25846058-3 2015 TYR, a typical polyphenol oxidase, can catalyze the oxidization of DA to o-quinone and therefore quenched the fluorescence of Au NCs. Dopamine 67-69 tyrosinase Homo sapiens 0-3 26626970-1 2016 A dopamine biosensor has been developed using nickel oxide nanoparticles (NPs) and tyrosinase enzyme conjugate. Dopamine 2-10 tyrosinase Homo sapiens 83-93 25846058-4 2015 Moreover, the reaction of TYR and DA gave rise to an emission band at 400 nm, which increased in a TYR/DA-concentration-dependent manner. Dopamine 34-36 tyrosinase Homo sapiens 99-102 25846058-4 2015 Moreover, the reaction of TYR and DA gave rise to an emission band at 400 nm, which increased in a TYR/DA-concentration-dependent manner. Dopamine 103-105 tyrosinase Homo sapiens 26-29 25846058-4 2015 Moreover, the reaction of TYR and DA gave rise to an emission band at 400 nm, which increased in a TYR/DA-concentration-dependent manner. Dopamine 103-105 tyrosinase Homo sapiens 99-102 24090870-0 2014 Design of a multiwalled carbon nanotube-Nafion-cysteamine modified tyrosinase biosensor and its adaptation of dopamine determination. Dopamine 110-118 tyrosinase Homo sapiens 67-77 24090870-1 2014 In this work, a multiwalled carbon nanotube (MWCNT)-Nafion-cysteamine (CA) modified tyrosinase biosensor brings a new and original perspective to biosensor technology intended for the development of dopamine determination. Dopamine 199-207 tyrosinase Homo sapiens 84-94 24917394-1 2014 Current evidence suggests that endogenous dopamine may act as a neurotoxin following its oxidation to an oquinone and reaction with cellular thiols, which are neutoxic, which may occur spontaneously or via reaction with tyrosinase or some other enzymes. Dopamine 42-50 tyrosinase Homo sapiens 220-230 24917394-4 2014 Therefore, tyrosinase may play a role in neuromelanin formation in the brain and could be central to dopamine neurotoxicity by contributing to the neurodegeneration associated with Parkinson"s disease. Dopamine 101-109 tyrosinase Homo sapiens 11-21 23252650-4 2013 Similarly, the effective quenching of the AgNCs by quinones enabled the detection of tyrosinase through the biocatalyzed oxidation of tyrosine, dopamine, or tyramine to the respective quinone products. Dopamine 144-152 tyrosinase Homo sapiens 85-95 20832343-4 2010 Experimental procedures were designed to test for alternative metabolic pathways of dopamine production, which included alternative substrates (tyramine and 3-methoxytyrosine) and alternative enzymes (tyrosinase and CYP2D6). Dopamine 84-92 tyrosinase Homo sapiens 201-211 23107737-0 2012 Synthesis and structure-activity relationships and effects of phenylpropanoid amides of octopamine and dopamine on tyrosinase inhibition and antioxidation. Dopamine 103-111 tyrosinase Homo sapiens 115-125 22040747-4 2012 The large surface area provided by the pores allowed the physical immobilization of tyrosinase, which is an enzyme that oxidizes dopamine, on the gates of the transistors, and thus, changes the acid-base behavior on their surfaces. Dopamine 129-137 tyrosinase Homo sapiens 84-94 22040747-5 2012 Concentration-dependent dopamine interacting with immobilized tyrosinase showed a linear dependence into a physiological range of interest for dopamine concentration in the changes of gate-source voltages. Dopamine 24-32 tyrosinase Homo sapiens 62-72 22040747-5 2012 Concentration-dependent dopamine interacting with immobilized tyrosinase showed a linear dependence into a physiological range of interest for dopamine concentration in the changes of gate-source voltages. Dopamine 143-151 tyrosinase Homo sapiens 62-72 18248610-0 2008 Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways. Dopamine 44-52 tyrosinase Homo sapiens 24-34 20480001-4 2010 Overexpression of tyrosinase resulted in increased intracellular dopamine content in association with the formation of melanin pigments in neuronal somata, which eventually causes apoptotic cell death. Dopamine 65-73 tyrosinase Homo sapiens 18-28 19386398-0 2009 Dopamine- and tyramine-based derivatives of triazenes: activation by tyrosinase and implications for prodrug design. Dopamine 0-8 tyrosinase Homo sapiens 69-79 19386398-2 2009 The prodrugs contained a tyramine or dopamine promoiety required for tyrosinase activation and this was joined via a urea functional group to the cytotoxic triazene. Dopamine 37-45 tyrosinase Homo sapiens 69-79 19836587-0 2009 Amperometric detection of dopamine based on tyrosinase-SWNTs-Ppy composite electrode. Dopamine 26-34 tyrosinase Homo sapiens 44-54 19836587-7 2009 This tyrosinase-SWNT-Ppy composite electrode was used for amperometric detection of dopamine in the presence of ascorbic acid and showed high sensitivity (467 mA/M cm(2)) and lower detection limit (5 microM) compared to previous reports. Dopamine 84-92 tyrosinase Homo sapiens 5-15 18720950-4 2008 The results were used to identify the role of each metal oxide in the immobilization matrix and fabricate a simple amperometric tyrosinase biosensor for the detection of phenol and dopamine. Dopamine 181-189 tyrosinase Homo sapiens 128-138 15885091-0 2005 Production and utilization of hydrogen peroxide associated with melanogenesis and tyrosinase-mediated oxidations of DOPA and dopamine. Dopamine 125-133 tyrosinase Homo sapiens 82-92 18358868-0 2008 Glutaraldehyde activated eggshell membrane for immobilization of tyrosinase from Amorphophallus companulatus: application in construction of electrochemical biosensor for dopamine. Dopamine 171-179 tyrosinase Homo sapiens 65-75 18358868-5 2008 Membrane bound enzyme exhibited consistent activity in the temperature range 20-45 degrees C. Shelf life of immobilized tyrosinase system was found to be more than 6 months when stored in phosphate buffer at 4 degrees C. An electrochemical biosensor for dopamine was developed by mounting the tyrosinase immobilized eggshell membrane on the surface of glassy carbon electrode. Dopamine 254-262 tyrosinase Homo sapiens 120-130 18358868-5 2008 Membrane bound enzyme exhibited consistent activity in the temperature range 20-45 degrees C. Shelf life of immobilized tyrosinase system was found to be more than 6 months when stored in phosphate buffer at 4 degrees C. An electrochemical biosensor for dopamine was developed by mounting the tyrosinase immobilized eggshell membrane on the surface of glassy carbon electrode. Dopamine 254-262 tyrosinase Homo sapiens 293-303 17567175-0 2007 Monitoring the activity of tyrosinase on a tyramine/dopamine-functionalized surface by force microscopy. Dopamine 52-60 tyrosinase Homo sapiens 27-37 17567175-1 2007 Tyrosinase activity is monitored by pi-donor-acceptor force interactions between a bipyridinium-modified AFM tip and the biocatalytic reaction product generated on a tyramine- (or dopamine-) modified surface. Dopamine 180-188 tyrosinase Homo sapiens 0-10 16621510-6 2007 Moreover, selective detection of dopamine (DA) in the presence of ascorbic acid (AA) has been demonstrated with the tyrosinase-modified ABDD electrode. Dopamine 33-41 tyrosinase Homo sapiens 116-126 16621510-6 2007 Moreover, selective detection of dopamine (DA) in the presence of ascorbic acid (AA) has been demonstrated with the tyrosinase-modified ABDD electrode. Dopamine 43-45 tyrosinase Homo sapiens 116-126 15968512-0 2005 Characterization of the monophenolase activity of tyrosinase on betaxanthins: the tyramine-betaxanthin/dopamine-betaxanthin pair. Dopamine 103-111 tyrosinase Homo sapiens 50-60 14511124-0 2003 Increased dopamine and its metabolites in SH-SY5Y neuroblastoma cells that express tyrosinase. Dopamine 10-18 tyrosinase Homo sapiens 83-93 15773923-3 2005 Whether tyrosinase is beneficial or detrimental to neurons is unclear; whilst the enzyme activity of tyrosinase generates dopamine-quinones and other oxidizing compounds, NM may form a sink for such radical species. Dopamine 122-130 tyrosinase Homo sapiens 101-111 15773923-6 2005 In cell culture systems, expression of tyrosinase increases neuronal susceptibility to oxidizing conditions, including dopamine itself. Dopamine 119-127 tyrosinase Homo sapiens 39-49 15773923-0 2005 Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson"s disease. Dopamine 23-31 tyrosinase Homo sapiens 0-10 14511124-4 2003 Overexpression of tyrosinase in cultured cell lines resulted in (i) increased intracellular dopamine content; (ii) induction of oxidase activity not only for DOPA but also for dopamine; (iii) formation of melanin pigments in cell soma; and (iv) increased intracellular reactive oxygen species. Dopamine 92-100 tyrosinase Homo sapiens 18-28 14511124-4 2003 Overexpression of tyrosinase in cultured cell lines resulted in (i) increased intracellular dopamine content; (ii) induction of oxidase activity not only for DOPA but also for dopamine; (iii) formation of melanin pigments in cell soma; and (iv) increased intracellular reactive oxygen species. Dopamine 176-184 tyrosinase Homo sapiens 18-28 11006597-6 2000 Conversely, when dopamine was used as tyrosinase substrate under UV light, mechanisms of melanogenesis different from those generated by simple enzymatic reaction without irradiation were not activated, as the same oligomeric species were present. Dopamine 17-25 tyrosinase Homo sapiens 38-48 12835121-0 2003 Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson"s disease. Dopamine 0-8 tyrosinase Homo sapiens 86-96 12835121-7 2003 The melanin-synthetic enzyme tyrosinase in the brain may rapidly oxidize excess amounts of cytosolic DA and L-DOPA, thereby preventing slowly progressive cell damage by auto-oxidation of DA, thus maintainng DA levels. Dopamine 101-103 tyrosinase Homo sapiens 29-39 12835121-7 2003 The melanin-synthetic enzyme tyrosinase in the brain may rapidly oxidize excess amounts of cytosolic DA and L-DOPA, thereby preventing slowly progressive cell damage by auto-oxidation of DA, thus maintainng DA levels. Dopamine 187-189 tyrosinase Homo sapiens 29-39 12835121-7 2003 The melanin-synthetic enzyme tyrosinase in the brain may rapidly oxidize excess amounts of cytosolic DA and L-DOPA, thereby preventing slowly progressive cell damage by auto-oxidation of DA, thus maintainng DA levels. Dopamine 187-189 tyrosinase Homo sapiens 29-39 12835121-8 2003 Since tyrosinase also possesses catecholamine-synthesizing activity in the absence of tyrosine hydroxylase (TH), the double-edged synthesizing and oxidizing functions of tyrosinase in the dopaminergic system suggest its potential for application in the synthesis of DA, instead of TH in the degeneration of dopaminergic neurons, and in the normalization of abnormal DA turnover in the long-term L-DOPA-treated Parkinson"s disease patients. Dopamine 266-268 tyrosinase Homo sapiens 6-16 12835121-8 2003 Since tyrosinase also possesses catecholamine-synthesizing activity in the absence of tyrosine hydroxylase (TH), the double-edged synthesizing and oxidizing functions of tyrosinase in the dopaminergic system suggest its potential for application in the synthesis of DA, instead of TH in the degeneration of dopaminergic neurons, and in the normalization of abnormal DA turnover in the long-term L-DOPA-treated Parkinson"s disease patients. Dopamine 266-268 tyrosinase Homo sapiens 170-180 12835121-8 2003 Since tyrosinase also possesses catecholamine-synthesizing activity in the absence of tyrosine hydroxylase (TH), the double-edged synthesizing and oxidizing functions of tyrosinase in the dopaminergic system suggest its potential for application in the synthesis of DA, instead of TH in the degeneration of dopaminergic neurons, and in the normalization of abnormal DA turnover in the long-term L-DOPA-treated Parkinson"s disease patients. Dopamine 366-368 tyrosinase Homo sapiens 6-16 12835121-8 2003 Since tyrosinase also possesses catecholamine-synthesizing activity in the absence of tyrosine hydroxylase (TH), the double-edged synthesizing and oxidizing functions of tyrosinase in the dopaminergic system suggest its potential for application in the synthesis of DA, instead of TH in the degeneration of dopaminergic neurons, and in the normalization of abnormal DA turnover in the long-term L-DOPA-treated Parkinson"s disease patients. Dopamine 366-368 tyrosinase Homo sapiens 170-180 11710108-2 2000 Using analogies from nature, we investigated the possibility that tyrosinase-catalyzed reactions of 3,4-dihydroxyphenethylamine (dopamine) could confer water-resistant adhesive properties to semidilute solutions of the polysaccharide chitosan. Dopamine 100-127 tyrosinase Homo sapiens 66-76 11710108-2 2000 Using analogies from nature, we investigated the possibility that tyrosinase-catalyzed reactions of 3,4-dihydroxyphenethylamine (dopamine) could confer water-resistant adhesive properties to semidilute solutions of the polysaccharide chitosan. Dopamine 129-137 tyrosinase Homo sapiens 66-76 10386977-2 1999 Peroxynitrite promoted the oxidation of dopamine to 6-hydroxyindole-5-one as characterised by HPLC and photodiode array spectra, akin to the products of the tyrosinase-dopamine reaction, but no evidence of dopamine nitration was obtained. Dopamine 40-48 tyrosinase Homo sapiens 157-167 10555861-6 1999 Using this new method, the presence of the dopaminechrome isomerase activity, which is involved in melanogenesis, could easily be detected by staining tyrosinase embedded native gels in dopamine solution. Dopamine 43-51 tyrosinase Homo sapiens 151-161 10555861-7 1999 Tyrosinase entrapped in the gels converts dopamine in dopaminechrome. Dopamine 42-50 tyrosinase Homo sapiens 0-10 7980401-5 1994 We demonstrate the method numerically by computer simulation of the reaction with added experimental errors and experimentally by the use of data from the kinetic study of the action of tyrosinase on dopamine. Dopamine 200-208 tyrosinase Homo sapiens 186-196 9843160-0 1998 Dopamine, in the presence of tyrosinase, covalently modifies and inactivates tyrosine hydroxylase. Dopamine 0-8 tyrosinase Homo sapiens 29-39 9736634-1 1998 Exposure of tryptophan hydroxylase (TPH), the initial and rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin, to dopamine under mild oxidizing conditions (iron + H2O2) or in the presence of tyrosinase results in a concentration-dependent inactivation of the enzyme. Dopamine 137-145 tyrosinase Homo sapiens 214-224 8818028-1 1996 Catalytic detection of dopamine in a flow-injection system based on a packed bed reactor containing immobilized tyrosinase is demonstrated. Dopamine 23-31 tyrosinase Homo sapiens 112-122 8915597-0 1996 Tyrosinase enhances the covalent modification of DNA by dopamine. Dopamine 56-64 tyrosinase Homo sapiens 0-10 8915597-1 1996 Dopamine-induced DNA damage was studied in vitro in the presence of the enzyme tyrosinase. Dopamine 0-8 tyrosinase Homo sapiens 79-89 8915597-3 1996 The conversion of dopamine to reactive dopamine quinone is accelerated by the enzyme tyrosinase. Dopamine 18-26 tyrosinase Homo sapiens 85-95 8915597-9 1996 The results suggest that DNA modification by dopamine is accelerated by tyrosinase which, in turn, could contribute to destruction of dopaminergic neurons in vivo. Dopamine 45-53 tyrosinase Homo sapiens 72-82 18966415-2 1995 Tyrosinase served as model enzyme and the biosensor response was characterized with respect to its response to dopamine. Dopamine 111-119 tyrosinase Homo sapiens 0-10 1298384-4 1992 For the immobilized tyrosinase reactor with photometric detection the range for dopamine is linear up to 0.75 mM (136 micrograms ml-1) and the immobilized tyrosinase reactor with electrochemical detection and the tyrosinase electrode extends this dynamic range to 1 mM (181 micrograms ml-1). Dopamine 80-88 tyrosinase Homo sapiens 20-30 8405659-2 1993 The oxidation of 3,4-dihydroxyphenylethylamine (dopamine) by O2 catalyzed by tyrosinase yields 4-(2-aminoethyl)-1,2-benzoquinone, with its amino group protonated (o-dopaminequinone-H+), which evolves non-enzymatically through two branches or sequences of reactions, whose respective operations are determined by the pH of the medium. Dopamine 17-46 tyrosinase Homo sapiens 77-87 8405659-2 1993 The oxidation of 3,4-dihydroxyphenylethylamine (dopamine) by O2 catalyzed by tyrosinase yields 4-(2-aminoethyl)-1,2-benzoquinone, with its amino group protonated (o-dopaminequinone-H+), which evolves non-enzymatically through two branches or sequences of reactions, whose respective operations are determined by the pH of the medium. Dopamine 48-56 tyrosinase Homo sapiens 77-87 8131222-5 1994 Tyrosinase was used to generate ortho-quinones from dopamine and alpha-methyldopa which may bind covalently to GST and thereupon irreversibly inhibit GST. Dopamine 52-60 tyrosinase Homo sapiens 0-10 8131222-7 1994 The inhibition (expressed as a % of control) after incubating 0.5 microM GST in the presence of 100 units/ml tyrosinase with 5 microM of the catecholamines for 10 min at 25 degrees, was 99% and 67% for dopamine and alpha-methyldopa, respectively. Dopamine 202-210 tyrosinase Homo sapiens 109-119 1910309-0 1991 Effect of pH on the oxidation pathway of dopamine catalyzed by tyrosinase. Dopamine 41-49 tyrosinase Homo sapiens 63-73 1910309-1 1991 The oxidation of 3,4-dihydroxyphenylethylamine (dopamine) by O2 catalyzed by tyrosinase yields 4-(2-aminoethyl)-1, 2-benzoquinone (o-dopaminequinone), which evolves nonenzymatically through two branches or sequences of reactions, whose respective operations are determined by the pH of the medium. Dopamine 17-46 tyrosinase Homo sapiens 77-87 1910309-1 1991 The oxidation of 3,4-dihydroxyphenylethylamine (dopamine) by O2 catalyzed by tyrosinase yields 4-(2-aminoethyl)-1, 2-benzoquinone (o-dopaminequinone), which evolves nonenzymatically through two branches or sequences of reactions, whose respective operations are determined by the pH of the medium. Dopamine 48-56 tyrosinase Homo sapiens 77-87 1910309-5 1991 The successful fitting of data to the kinetic behavior predicted by the kinetic analysis at both pH greater than or equal to 6 and pH less than 6 confirms the overall oxidation pathway proposed for the dopamine oxidation catalyzed by tyrosinase. Dopamine 202-210 tyrosinase Homo sapiens 234-244 2117268-3 1990 Phenylthiourea, which completely inhibited tyrosinase activity with minimal cytotoxicity was found to block the growth inhibitory activity of the antitumor dopamine analog 3,4-dihydroxybenzylamine (3,4-DHBA) (NSC 263475). Dopamine 156-164 tyrosinase Homo sapiens 43-53 1653780-5 1991 The growth of neuroblastoma tumours was inhibited by different mechanisms: L-dopa and its metabolite dopamine reduced the activity of tyrosinase, BSO reduced glutathione levels, and L-dopa and tamoxifen raised cAMP concentrations. Dopamine 101-109 tyrosinase Homo sapiens 134-144 33825048-3 2021 First, TYR catalyzes the oxidation of tyramine hydrochloride to dopamine and then to dopamine-o-quinone. Dopamine 64-72 tyrosinase Homo sapiens 7-10 3149665-0 1987 Kinetic characterization of dopamine as a suicide substrate of tyrosinase. Dopamine 28-36 tyrosinase Homo sapiens 63-73 35456994-5 2022 DA in cytoplasm is highly reactive and is assumed to be oxidized spontaneously or by an unidentified tyrosinase to DAQ and then, synthesized to NM. Dopamine 0-2 tyrosinase Homo sapiens 101-111 3149665-1 1987 A kinetic study of the inactivation of frog epidermis tyrosinase by a suicide substrate dopamine hydrochloride is described. Dopamine 88-110 tyrosinase Homo sapiens 54-64 32729488-1 2020 We present a tyrosinase-conjugated zinc oxide-reduced graphene oxide (Tyr/ZnO-rGO) nanocomposite system as a biosensing test-bed for rapid and sensitive detection of dopamine (DA). Dopamine 166-174 tyrosinase Homo sapiens 13-23 33654383-0 2021 Dopamine-Mediated Vanillin Multicomponent Derivative Synthesis via Grindstone Method: Application of Antioxidant, Anti-Tyrosinase, and Cytotoxic Activities. Dopamine 0-8 tyrosinase Homo sapiens 119-129 33654383-1 2021 Purpose: This study aimed to determine the extent of contribution of dopamine to antioxidant and anti-tyrosinase activities, by dopamine addition to vanillin. Dopamine 69-77 tyrosinase Homo sapiens 102-112 33654383-1 2021 Purpose: This study aimed to determine the extent of contribution of dopamine to antioxidant and anti-tyrosinase activities, by dopamine addition to vanillin. Dopamine 128-136 tyrosinase Homo sapiens 102-112 33654383-2 2021 This study achieved the synthesis of dopamine-associated vanillin Mannich base derivatives prepared via a one-step reaction involving a green chemistry approach, and investigation of antioxidant and anti-tyrosinase activities. Dopamine 37-45 tyrosinase Homo sapiens 204-214 6441736-2 1984 The enzyme activity was detected by staining the gels with L-3,4-dihydroxyphenylalanine, dopamine and 5,6-dihydroxyindole as substrates for tyrosinase (EC 1.14.18.1). Dopamine 89-97 tyrosinase Homo sapiens 140-150 6173137-0 1981 Inhibition of reverse transcriptase by tyrosinase generated quinones related to levodopa and dopamine. Dopamine 93-101 tyrosinase Homo sapiens 39-49 34030092-5 2021 Just by simple removal of a permanent magnet, dopamine on the biosensor interface are catalyzed by tyrosinase, thus achieving the regeneration of the biosensor. Dopamine 46-54 tyrosinase Homo sapiens 99-109 32729488-1 2020 We present a tyrosinase-conjugated zinc oxide-reduced graphene oxide (Tyr/ZnO-rGO) nanocomposite system as a biosensing test-bed for rapid and sensitive detection of dopamine (DA). Dopamine 176-178 tyrosinase Homo sapiens 13-23 31782480-0 2020 Functionalized tungsten disulfide nanotubes for dopamine and catechol detection in a tyrosinase-based amperometric biosensor design. Dopamine 48-56 tyrosinase Homo sapiens 85-95 32664213-3 2020 Compared to the PDA films obtained by the similar enzymatic oxidation of 1 mM dopamine with tyrosinase (T-PDA), psi-PDA displayed slower deposition kinetics, lower water contact angles in the range of 11 -28 , denoting higher hydrophilicity but similar UV-vis absorption profiles, as well as electrochemical properties and antioxidant activity. Dopamine 78-86 tyrosinase Homo sapiens 92-102 31782480-1 2020 WS2 nanotubes functionalized with carboxylic acid functions (WS2-COOH) were used for improved immobilization of the enzyme tyrosinase in order to form an electrochemical biosensor towards catechol and dopamine. Dopamine 201-209 tyrosinase Homo sapiens 123-133 31776798-4 2019 TYR catalyzes the oxidation of DA while CAT can decompose H2O2 into water and oxygen. Dopamine 31-33 tyrosinase Homo sapiens 0-3