PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12724841-6 2003 GDNF was carried by retrograde transport to dopamine neurons in the ipsilateral substantia nigra, stimulating an 18% increase in the number of tyrosine hydroxylase (TH)-positive dopamine neurons and a 28% increase in dopamine neuron perikaryal size. Dopamine 44-52 glial cell derived neurotrophic factor Macaca mulatta 0-4 16049934-1 2005 Glial cell line-derived neurotrophic factor (GDNF) promotes the survival, growth, and regeneration of dopamine neurons in the midbrain that degenerate in Parkinson"s disease. Dopamine 102-110 glial cell derived neurotrophic factor Macaca mulatta 0-43 16049934-1 2005 Glial cell line-derived neurotrophic factor (GDNF) promotes the survival, growth, and regeneration of dopamine neurons in the midbrain that degenerate in Parkinson"s disease. Dopamine 102-110 glial cell derived neurotrophic factor Macaca mulatta 45-49 16049934-8 2005 Increasing the dose threefold did not increase efficacy, suggesting that after achieving a critical threshold, GDNF tissue distribution is more important than dose for trophic stimulation of dopamine neurons. Dopamine 191-199 glial cell derived neurotrophic factor Macaca mulatta 111-115 18522244-2 2008 Here we report the monitoring of GDNF-induced functional changes of the basal ganglia in hemiparkinsonian monkeys via pharmacological MRI measuring the blood oxygenation level-dependent (BOLD) response to a direct dopamine agonist (apomorphine, APO). Dopamine 214-222 glial cell derived neurotrophic factor Macaca mulatta 33-37 12724841-6 2003 GDNF was carried by retrograde transport to dopamine neurons in the ipsilateral substantia nigra, stimulating an 18% increase in the number of tyrosine hydroxylase (TH)-positive dopamine neurons and a 28% increase in dopamine neuron perikaryal size. Dopamine 178-186 glial cell derived neurotrophic factor Macaca mulatta 0-4 12724841-6 2003 GDNF was carried by retrograde transport to dopamine neurons in the ipsilateral substantia nigra, stimulating an 18% increase in the number of tyrosine hydroxylase (TH)-positive dopamine neurons and a 28% increase in dopamine neuron perikaryal size. Dopamine 178-186 glial cell derived neurotrophic factor Macaca mulatta 0-4 9749583-1 1998 Glial cell line-derived neurotrophic factor (GDNF) promotes recovery of the injured nigrostriatal dopamine system and improves motor functions in both rodent and nonhuman primate models of Parkinson"s disease (PD). Dopamine 98-106 glial cell derived neurotrophic factor Macaca mulatta 0-43 12629203-0 2003 Glial cell line-derived neurotrophic factor increases stimulus-evoked dopamine release and motor speed in aged rhesus monkeys. Dopamine 70-78 glial cell derived neurotrophic factor Macaca mulatta 0-43 12629203-2 2003 Here, we report the effects of glial cell line-derived neurotrophic factor (GDNF) on the stimulus-evoked release of dopamine and motor speed in aged monkeys (21-27 years of age; n = 10). Dopamine 116-124 glial cell derived neurotrophic factor Macaca mulatta 31-74 12629203-2 2003 Here, we report the effects of glial cell line-derived neurotrophic factor (GDNF) on the stimulus-evoked release of dopamine and motor speed in aged monkeys (21-27 years of age; n = 10). Dopamine 116-124 glial cell derived neurotrophic factor Macaca mulatta 76-80 12629203-6 2003 The stimulus-evoked release of dopamine was significantly increased, up to 130% in the right caudate nucleus and putamen and up to 116% in both the right and left substantia nigra of the aged GDNF recipients compared with vehicle controls. Dopamine 31-39 glial cell derived neurotrophic factor Macaca mulatta 192-196 12629203-7 2003 Also, basal extracellular levels of dopamine were bilaterally increased, up to 163% in the substantia nigra of the aged GDNF-treated animals. Dopamine 36-44 glial cell derived neurotrophic factor Macaca mulatta 120-124 12629203-8 2003 The data suggest that the effects of GDNF on the release of dopamine in the basal ganglia may be responsible for the improvements in motor functions and support the hypothesis that functional changes in dopamine release may contribute to motor dysfunctions characterizing senescence. Dopamine 60-68 glial cell derived neurotrophic factor Macaca mulatta 37-41 12244077-1 2002 The powerful trophic effects that glial cell line-derived neurotrophic factor (GDNF) exerts on midbrain dopamine neurones suggest its use in treating Parkinson"s disease. Dopamine 104-112 glial cell derived neurotrophic factor Macaca mulatta 34-77 12244077-1 2002 The powerful trophic effects that glial cell line-derived neurotrophic factor (GDNF) exerts on midbrain dopamine neurones suggest its use in treating Parkinson"s disease. Dopamine 104-112 glial cell derived neurotrophic factor Macaca mulatta 79-83 9889359-0 1999 GDNF improves dopamine function in the substantia nigra but not the putamen of unilateral MPTP-lesioned rhesus monkeys. Dopamine 14-22 glial cell derived neurotrophic factor Macaca mulatta 0-4 9808338-5 1998 In addition to its effects on cultured fetal midbrain dopamine neurons, GDNF promotes recovery of the injured nigrostriatal dopamine system and improves motor functions in rodent and nonhuman primate models of Parkinson"s disease. Dopamine 124-132 glial cell derived neurotrophic factor Macaca mulatta 72-76 9808338-8 1998 In this model, adult midbrain dopamine neurons stimulated by GDNF show increased cell size, neuritic extent, and expression of phenotypic markers. Dopamine 30-38 glial cell derived neurotrophic factor Macaca mulatta 61-65 9808338-10 1998 GDNF also induces neuroprotective changes in dopamine neurons, which are active within hours following trophic factor administration in rodents. Dopamine 45-53 glial cell derived neurotrophic factor Macaca mulatta 0-4 11166735-1 2001 Glial cell line-derived neurotrophic factor (GDNF) has previously reduced motor deficits and preserved nigral dopamine neurones in rhesus monkeys with a unilateral MPTP-induced lesion of substantia nigra. Dopamine 110-118 glial cell derived neurotrophic factor Macaca mulatta 0-43 11166735-1 2001 Glial cell line-derived neurotrophic factor (GDNF) has previously reduced motor deficits and preserved nigral dopamine neurones in rhesus monkeys with a unilateral MPTP-induced lesion of substantia nigra. Dopamine 110-118 glial cell derived neurotrophic factor Macaca mulatta 45-49 9889359-8 1999 In addition, d-amphetamine-evoked overflow of DA was significantly increased in the substantia nigra but not the putamen of MPTP-lesioned monkeys that had received GDNF. Dopamine 46-48 glial cell derived neurotrophic factor Macaca mulatta 164-168 9749583-1 1998 Glial cell line-derived neurotrophic factor (GDNF) promotes recovery of the injured nigrostriatal dopamine system and improves motor functions in both rodent and nonhuman primate models of Parkinson"s disease (PD). Dopamine 98-106 glial cell derived neurotrophic factor Macaca mulatta 45-49 9749583-3 1998 Adult midbrain dopamine neurons stimulated by GDNF show increased cell size, neurite extent, and expression of phenotypic markers. Dopamine 15-23 glial cell derived neurotrophic factor Macaca mulatta 46-50 9749583-6 1998 GDNF also induces neuroprotective changes in dopamine neurons which are active within hours after trophic factor administration. Dopamine 45-53 glial cell derived neurotrophic factor Macaca mulatta 0-4 8847404-5 1995 In vivo electrochemical recordings in the ipsilateral caudate and putamen 3 weeks after GDNF administration revealed increased potassium-evoked release of dopamine in trophic factor recipients. Dopamine 155-163 glial cell derived neurotrophic factor Macaca mulatta 88-92 8637574-6 1996 On the lesioned side of GDNF-treated animals, dopamine levels in the midbrain and globus pallidus were twice as high, and nigral dopamine neurons were, on average, 20% larger, with an increased fibre density. Dopamine 46-54 glial cell derived neurotrophic factor Macaca mulatta 24-28 8637574-6 1996 On the lesioned side of GDNF-treated animals, dopamine levels in the midbrain and globus pallidus were twice as high, and nigral dopamine neurons were, on average, 20% larger, with an increased fibre density. Dopamine 129-137 glial cell derived neurotrophic factor Macaca mulatta 24-28 8847404-6 1995 In a second series of animals killed at the same time, dopamine levels in the substantia nigra and ventral tegmental area of GDNF recipients were significantly increased, with ipsilateral values more than 200% higher than contralateral and control levels. Dopamine 55-63 glial cell derived neurotrophic factor Macaca mulatta 125-129 8847404-8 1995 There was a trend toward increased HVA levels in the ipsilateral putamen, nucleus accumbens, and globus pallidus in GDNF-treated animals, but the ratios of HVA to dopamine were not significantly different between vehicle- and GDNF-treated recipients. Dopamine 163-171 glial cell derived neurotrophic factor Macaca mulatta 116-120 8847404-10 1995 In the substantia nigra ipsilateral to GDNF administration, dopamine-neuron perikaryal size was significantly increased, along with a significant increase in tyrosine hydroxylase-positive axons and dendrites. Dopamine 60-68 glial cell derived neurotrophic factor Macaca mulatta 39-43 8847404-11 1995 We conclude that, in the adult rhesus monkey, a single intranigral GDNF injection induces a significant upregulation of mesencephalic dopamine neurons which lasts for weeks. Dopamine 134-142 glial cell derived neurotrophic factor Macaca mulatta 67-71