PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31740235-9 2020 In PC12 cells, the decrease of DA content was mainly due to the downregulation of DOPA decarboxylase (DDC) expression caused by Mn3O4 NPs treatment. Dopamine 31-33 dopa decarboxylase Rattus norvegicus 82-100 30651588-6 2019 In the adrenal glands of adult SHR, the expression of catecholamine biosynthetic enzymes Th, Ddc, Dbh and Pnmt was decreased along the amounts of dopamine and noradrenaline (50% and 38%, respectively, p < 0.001). Dopamine 146-154 dopa decarboxylase Rattus norvegicus 93-96 32342310-2 2020 Only recently we showed that DA in SCN is synthesized together by nerve fibers containing only tyrosine hydroxylase (TH) and neurons containing only aromatic L-amino acid decarboxylase (AADC). Dopamine 29-31 dopa decarboxylase Rattus norvegicus 158-184 32342310-2 2020 Only recently we showed that DA in SCN is synthesized together by nerve fibers containing only tyrosine hydroxylase (TH) and neurons containing only aromatic L-amino acid decarboxylase (AADC). Dopamine 29-31 dopa decarboxylase Rattus norvegicus 186-190 29225571-1 2017 Aromatic L-amino acid decarboxylase (AADC) is an essential enzyme in the synthesis of serotonin, dopamine, and certain trace amines and is present in a variety of organs including the brain and spinal cord. Dopamine 97-105 dopa decarboxylase Rattus norvegicus 0-35 29225571-1 2017 Aromatic L-amino acid decarboxylase (AADC) is an essential enzyme in the synthesis of serotonin, dopamine, and certain trace amines and is present in a variety of organs including the brain and spinal cord. Dopamine 97-105 dopa decarboxylase Rattus norvegicus 37-41 28622392-7 2017 This combination therapeutic strategy indeed showed an enhanced benefit in restoring the motor function of severely lesioned PD rats by providing the neuroprotective effect of CDNF and dopamine enhancing effect of AADC as expected. Dopamine 185-193 dopa decarboxylase Rattus norvegicus 214-218 28166239-11 2017 After L-DOPA administration in MPTP-treated NHP, very poor conversion to DA was detected, suggesting that AADC in NHP nigrostriatal fibers is mainly responsible for L-DOPA to DA conversion. Dopamine 175-177 dopa decarboxylase Rattus norvegicus 106-110 24323403-7 2014 The expression of dopamine neurons markers, such as dopamine-beta-hydroxy (DBH), dopa decarboxylase (DDC) and tyrosine hydroxylase (TH), was significantly upregulated after treatment with salidroside for 1-12 days. Dopamine 18-26 dopa decarboxylase Rattus norvegicus 81-99 26830512-0 2016 Production of Dopamine by Aromatic l-Amino Acid Decarboxylase Cells after Spinal Cord Injury. Dopamine 14-22 dopa decarboxylase Rattus norvegicus 26-61 26830512-3 2016 Because AADC is a common enzyme catalyzing 5-hydroxytryptophan to serotonin and l-3,4-dihydroxyphenylalanine (l-dopa) to dopamine (DA), it seems likely that the ability of AADC cells using l-dopa to synthesize DA is also increased. Dopamine 121-129 dopa decarboxylase Rattus norvegicus 8-12 26830512-3 2016 Because AADC is a common enzyme catalyzing 5-hydroxytryptophan to serotonin and l-3,4-dihydroxyphenylalanine (l-dopa) to dopamine (DA), it seems likely that the ability of AADC cells using l-dopa to synthesize DA is also increased. Dopamine 131-133 dopa decarboxylase Rattus norvegicus 8-12 26830512-3 2016 Because AADC is a common enzyme catalyzing 5-hydroxytryptophan to serotonin and l-3,4-dihydroxyphenylalanine (l-dopa) to dopamine (DA), it seems likely that the ability of AADC cells using l-dopa to synthesize DA is also increased. Dopamine 131-133 dopa decarboxylase Rattus norvegicus 172-176 26830512-9 2016 These findings demonstrate that AADC cells in the spinal cord below the lesion gain the ability to produce DA from its precursor in response to SCI. Dopamine 107-109 dopa decarboxylase Rattus norvegicus 32-36 24323403-7 2014 The expression of dopamine neurons markers, such as dopamine-beta-hydroxy (DBH), dopa decarboxylase (DDC) and tyrosine hydroxylase (TH), was significantly upregulated after treatment with salidroside for 1-12 days. Dopamine 18-26 dopa decarboxylase Rattus norvegicus 101-104 20407462-1 2011 The catecholamine, dopamine (DA), is synthesized from 3,4-dihydroxy-L-phenylalanine (L-DOPA) by aromatic L-amino acid decarboxylase (AADC). Dopamine 19-27 dopa decarboxylase Rattus norvegicus 105-131 23196068-4 2013 Since l-dopa could be decarboxylated by aromatic amino acid decarboxylase (AADC) present within both dopamine and serotonin neurons, it was hypothesized that serotonin neurons convert l-dopa into dopamine to generate excessive reactive oxygen species and quinoproteins that ultimately lead to serotonin neuron death. Dopamine 101-109 dopa decarboxylase Rattus norvegicus 75-79 23196068-4 2013 Since l-dopa could be decarboxylated by aromatic amino acid decarboxylase (AADC) present within both dopamine and serotonin neurons, it was hypothesized that serotonin neurons convert l-dopa into dopamine to generate excessive reactive oxygen species and quinoproteins that ultimately lead to serotonin neuron death. Dopamine 196-204 dopa decarboxylase Rattus norvegicus 75-79 23196068-9 2013 Dopamine, ROS production and cell death were attenuated by co-incubation with the AADC inhibitor, NSD-1015. Dopamine 0-8 dopa decarboxylase Rattus norvegicus 82-86 20407462-1 2011 The catecholamine, dopamine (DA), is synthesized from 3,4-dihydroxy-L-phenylalanine (L-DOPA) by aromatic L-amino acid decarboxylase (AADC). Dopamine 19-27 dopa decarboxylase Rattus norvegicus 133-137 20407462-1 2011 The catecholamine, dopamine (DA), is synthesized from 3,4-dihydroxy-L-phenylalanine (L-DOPA) by aromatic L-amino acid decarboxylase (AADC). Dopamine 29-31 dopa decarboxylase Rattus norvegicus 105-131 20407462-1 2011 The catecholamine, dopamine (DA), is synthesized from 3,4-dihydroxy-L-phenylalanine (L-DOPA) by aromatic L-amino acid decarboxylase (AADC). Dopamine 29-31 dopa decarboxylase Rattus norvegicus 133-137 20542064-2 2010 The anti-parkinsonian and pro-dyskinetic actions of L-DOPA are widely attributed to its conversion, by the enzyme aromatic L-amino acid decarboxylase (AADC), to dopamine. Dopamine 161-169 dopa decarboxylase Rattus norvegicus 123-149 20542064-2 2010 The anti-parkinsonian and pro-dyskinetic actions of L-DOPA are widely attributed to its conversion, by the enzyme aromatic L-amino acid decarboxylase (AADC), to dopamine. Dopamine 161-169 dopa decarboxylase Rattus norvegicus 151-155 19449783-7 2009 In this case, L-tyrosine is transformed to L-DOPA in TH containing neurons that is followed by L-DOPA release and uptake to AADC containing neurons with a semi-specific membrane transporter of large neutral amino acids for DA synthesis. Dopamine 223-225 dopa decarboxylase Rattus norvegicus 124-128 19903816-5 2010 Aromatic amino acid decarboxylase (AADC) then converts di-OH-phenylalanine into DA. Dopamine 80-82 dopa decarboxylase Rattus norvegicus 35-39 19903816-12 2010 Finally, the coupling between synthesis and transport of DA into vesicles was impaired in the presence of fragments involved in the VMAT(2)/TH/AADC interaction. Dopamine 57-59 dopa decarboxylase Rattus norvegicus 143-147 21783893-8 2008 These results suggest that catalpalactone inhibited dopamine biosynthesis by reducing TH and AADC activities and enhanced L-DOPA-induced cytotoxiciy in PC12 cells. Dopamine 52-60 dopa decarboxylase Rattus norvegicus 93-97 18602388-9 2008 One pathway involves l-DOPA directly entering the cells to convert dopamine through AADC activity (l-DOPA decarboxylation). Dopamine 67-75 dopa decarboxylase Rattus norvegicus 84-88 16504219-5 2006 In rats treated with 6-hydroxydopamine (6-OHDA) to lesion the nigrostriatal dopamine (DA) pathway, DOPA significantly induced c-Fos expression in the four regions under the inhibition of peripheral AADC. Dopamine 30-38 dopa decarboxylase Rattus norvegicus 198-202 17259019-6 2007 We found here that repeated administration of levodopa, added with the peripheral DOPA decarboxylase inhibitor carbidopa, increased dopamine turnover rate after lesioning the striatum with 6-hydroxydopamine. Dopamine 132-140 dopa decarboxylase Rattus norvegicus 82-100 16736236-4 2006 The inhibition of DOPA decarboxylase blocked dopamine synthesis. Dopamine 45-53 dopa decarboxylase Rattus norvegicus 18-36 16504219-5 2006 In rats treated with 6-hydroxydopamine (6-OHDA) to lesion the nigrostriatal dopamine (DA) pathway, DOPA significantly induced c-Fos expression in the four regions under the inhibition of peripheral AADC. Dopamine 44-46 dopa decarboxylase Rattus norvegicus 198-202 16182313-3 2006 The renal aromatic l-amino acid decarboxylase (AADC) activity, the enzyme responsible for the synthesis of renal dopamine, was evaluated during negligible proteinuria accompanied with enhanced sodium retention (day 7), increased proteinuria accompanied with greatest sodium retention (day 14) as well as during increased proteinuria accompanied with negative sodium balance (day 21). Dopamine 113-121 dopa decarboxylase Rattus norvegicus 10-45 16182313-3 2006 The renal aromatic l-amino acid decarboxylase (AADC) activity, the enzyme responsible for the synthesis of renal dopamine, was evaluated during negligible proteinuria accompanied with enhanced sodium retention (day 7), increased proteinuria accompanied with greatest sodium retention (day 14) as well as during increased proteinuria accompanied with negative sodium balance (day 21). Dopamine 113-121 dopa decarboxylase Rattus norvegicus 47-51 16204272-4 2006 The rats were sacrificed during greatest sodium retention (day 7) as well as during negative sodium balance (day 14) for the evaluation of renal aromatic l-amino acid decarboxylase (AADC) activity, the enzyme responsible for the synthesis of renal dopamine. Dopamine 248-256 dopa decarboxylase Rattus norvegicus 154-180 16204272-4 2006 The rats were sacrificed during greatest sodium retention (day 7) as well as during negative sodium balance (day 14) for the evaluation of renal aromatic l-amino acid decarboxylase (AADC) activity, the enzyme responsible for the synthesis of renal dopamine. Dopamine 248-256 dopa decarboxylase Rattus norvegicus 182-186 16182609-5 2006 Using this strategy, aromatic L-amino acid decarboxylase (AADC) activity was retained so that l-3,4-dihydroxyphenylalanine (L-dopa), a substrate for AADC, could be converted to dopamine in the striatum and the therapeutic effects of L-dopa preserved, even after reduction of TH expression in the case of dopamine overproduction. Dopamine 177-185 dopa decarboxylase Rattus norvegicus 21-56 16269145-4 2006 Using primary fibroblast doubly transduced with VMAT-2 and aromatic L-amino acid decarboxylase (AADC) genes, we previously demonstrated the beneficial effects of such double gene transduction in the production, storage, and gradual release of dopamine in vitro and in vivo. Dopamine 243-251 dopa decarboxylase Rattus norvegicus 59-94 16269145-4 2006 Using primary fibroblast doubly transduced with VMAT-2 and aromatic L-amino acid decarboxylase (AADC) genes, we previously demonstrated the beneficial effects of such double gene transduction in the production, storage, and gradual release of dopamine in vitro and in vivo. Dopamine 243-251 dopa decarboxylase Rattus norvegicus 96-100 16182609-5 2006 Using this strategy, aromatic L-amino acid decarboxylase (AADC) activity was retained so that l-3,4-dihydroxyphenylalanine (L-dopa), a substrate for AADC, could be converted to dopamine in the striatum and the therapeutic effects of L-dopa preserved, even after reduction of TH expression in the case of dopamine overproduction. Dopamine 177-185 dopa decarboxylase Rattus norvegicus 58-62 16182609-5 2006 Using this strategy, aromatic L-amino acid decarboxylase (AADC) activity was retained so that l-3,4-dihydroxyphenylalanine (L-dopa), a substrate for AADC, could be converted to dopamine in the striatum and the therapeutic effects of L-dopa preserved, even after reduction of TH expression in the case of dopamine overproduction. Dopamine 177-185 dopa decarboxylase Rattus norvegicus 149-153 16182609-5 2006 Using this strategy, aromatic L-amino acid decarboxylase (AADC) activity was retained so that l-3,4-dihydroxyphenylalanine (L-dopa), a substrate for AADC, could be converted to dopamine in the striatum and the therapeutic effects of L-dopa preserved, even after reduction of TH expression in the case of dopamine overproduction. Dopamine 304-312 dopa decarboxylase Rattus norvegicus 21-56 16182609-5 2006 Using this strategy, aromatic L-amino acid decarboxylase (AADC) activity was retained so that l-3,4-dihydroxyphenylalanine (L-dopa), a substrate for AADC, could be converted to dopamine in the striatum and the therapeutic effects of L-dopa preserved, even after reduction of TH expression in the case of dopamine overproduction. Dopamine 304-312 dopa decarboxylase Rattus norvegicus 58-62 16182609-5 2006 Using this strategy, aromatic L-amino acid decarboxylase (AADC) activity was retained so that l-3,4-dihydroxyphenylalanine (L-dopa), a substrate for AADC, could be converted to dopamine in the striatum and the therapeutic effects of L-dopa preserved, even after reduction of TH expression in the case of dopamine overproduction. Dopamine 304-312 dopa decarboxylase Rattus norvegicus 149-153 16088079-5 2005 In both PAN- and HgCl(2)-induced nephrosis, the jejunal aromatic L-amino acid decarboxylase (AADC) activity, the enzyme responsible for the synthesis of jejunal dopamine, did not differ from controls. Dopamine 161-169 dopa decarboxylase Rattus norvegicus 65-91 16088079-5 2005 In both PAN- and HgCl(2)-induced nephrosis, the jejunal aromatic L-amino acid decarboxylase (AADC) activity, the enzyme responsible for the synthesis of jejunal dopamine, did not differ from controls. Dopamine 161-169 dopa decarboxylase Rattus norvegicus 93-97 15836622-4 2005 Infusion of this vector into the striatum of parkinsonian rats and monkeys improves L-DOPA responsiveness by improving AADC-mediated conversion of L-DOPA to dopamine. Dopamine 157-165 dopa decarboxylase Rattus norvegicus 119-123 15705351-6 2005 An acute dopamine-depleting treatment of the slices with the dopa-decarboxylase inhibitor carbidopa significantly reduced the effects of methylphenidate. Dopamine 9-17 dopa decarboxylase Rattus norvegicus 61-79 15627800-5 2005 The V(max) values for renal aromatic L-amino acid decarboxylase, the enzyme responsible for the synthesis of renal dopamine, were decreased in (3/4)nx rats. Dopamine 115-123 dopa decarboxylase Rattus norvegicus 28-63 15380638-1 2004 Parkinson"s disease is a neurodegenerative disease and its symptoms are relieved by administration of L-dopa (LD), which is converted by neuronal aromatic L-aminoacid decarboxylase (AADC), restoring dopamine (DA) levels in surviving neurons. Dopamine 199-207 dopa decarboxylase Rattus norvegicus 155-180 15380638-1 2004 Parkinson"s disease is a neurodegenerative disease and its symptoms are relieved by administration of L-dopa (LD), which is converted by neuronal aromatic L-aminoacid decarboxylase (AADC), restoring dopamine (DA) levels in surviving neurons. Dopamine 199-207 dopa decarboxylase Rattus norvegicus 182-186 15380638-1 2004 Parkinson"s disease is a neurodegenerative disease and its symptoms are relieved by administration of L-dopa (LD), which is converted by neuronal aromatic L-aminoacid decarboxylase (AADC), restoring dopamine (DA) levels in surviving neurons. Dopamine 209-211 dopa decarboxylase Rattus norvegicus 155-180 15380638-1 2004 Parkinson"s disease is a neurodegenerative disease and its symptoms are relieved by administration of L-dopa (LD), which is converted by neuronal aromatic L-aminoacid decarboxylase (AADC), restoring dopamine (DA) levels in surviving neurons. Dopamine 209-211 dopa decarboxylase Rattus norvegicus 182-186 15462205-9 2004 This study provides a convincing evidence of dopamine synthesis by non-dopaminergic neurons expressing TH or AADC, in cooperation. Dopamine 45-53 dopa decarboxylase Rattus norvegicus 109-113 15158168-5 2004 The in vivo microdialysis technique was used to measure accumulation of the dopamine precursor DOPA following intra-accumbal administration of the DOPA decarboxylase inhibitor NSD 1015 through the microdialysis probe. Dopamine 76-84 dopa decarboxylase Rattus norvegicus 147-165 12713518-5 2003 Uninephrectomy was accompanied in W-H rats by increases in urinary levels (nmol g kidney(-1) day(-1)) of dopamine (10.3 +/- 0.5 vs. 8.3 +/- 0.7, P < 0.05) and 3,4-dihydroxyphenylacetic acid (DOPAC) (30.5 +/- 3.7 vs. 21.3 +/- 1.4, P < 0.05) and increases (P < 0.05) in maximal velocity values (Vmax in nmol mg prot(-1) 15 min(-1), 325 +/- 12 vs. 265 +/- 3) for renal aromatic L-amino acid decarboxylase (AADC), the enzyme responsible for the synthesis of renal dopamine. Dopamine 105-113 dopa decarboxylase Rattus norvegicus 384-410 15030379-1 2004 AIMS: The present study aimed to evaluate the relationship between intestinal inflammation, interferon-gamma (IFN-gamma) levels and intestinal levels of dopamine, its precursor l-3,4-dihydroxyphenylalanine (L-DOPA), and the activity of aromatic L-amino acid decarboxylase (AADC) activity along the digestive tract in a rat experimental model of colitis. Dopamine 153-161 dopa decarboxylase Rattus norvegicus 245-271 15030379-1 2004 AIMS: The present study aimed to evaluate the relationship between intestinal inflammation, interferon-gamma (IFN-gamma) levels and intestinal levels of dopamine, its precursor l-3,4-dihydroxyphenylalanine (L-DOPA), and the activity of aromatic L-amino acid decarboxylase (AADC) activity along the digestive tract in a rat experimental model of colitis. Dopamine 153-161 dopa decarboxylase Rattus norvegicus 273-277 14701706-3 2004 Alveolar Type II cells express the enzyme aromatic-L-amino acid decarboxylase (AADC) and, when incubated with the dopamine precursor, 3-hydroxy-L-tyrosine (L-dopa), produce dopamine. Dopamine 114-122 dopa decarboxylase Rattus norvegicus 42-77 14701706-3 2004 Alveolar Type II cells express the enzyme aromatic-L-amino acid decarboxylase (AADC) and, when incubated with the dopamine precursor, 3-hydroxy-L-tyrosine (L-dopa), produce dopamine. Dopamine 173-181 dopa decarboxylase Rattus norvegicus 42-77 14701706-3 2004 Alveolar Type II cells express the enzyme aromatic-L-amino acid decarboxylase (AADC) and, when incubated with the dopamine precursor, 3-hydroxy-L-tyrosine (L-dopa), produce dopamine. Dopamine 173-181 dopa decarboxylase Rattus norvegicus 79-83 14701706-4 2004 Rats fed TSD, a precursor of L-dopa and dopamine, had increased urinary dopamine levels, which were inhibited by benserazide, an inhibitor of AADC. Dopamine 40-48 dopa decarboxylase Rattus norvegicus 142-146 14701706-4 2004 Rats fed TSD, a precursor of L-dopa and dopamine, had increased urinary dopamine levels, which were inhibited by benserazide, an inhibitor of AADC. Dopamine 72-80 dopa decarboxylase Rattus norvegicus 142-146 14980733-1 2004 This study was aimed to test our hypothesis about dopamine (DA) synthesis by non-DAergic neurons expressing individual complementary enzymes of the DA synthetic pathway in cooperation, i.e. L-dihydroxyphenylalanine (L-DOPA) synthesized in tyrosine hydroxylase (TH)-expressing neurons is transported to aromatic L-amino acid decarboxylase (AADC)-expressing neurons for conversion to DA. Dopamine 50-58 dopa decarboxylase Rattus norvegicus 311-337 14980733-1 2004 This study was aimed to test our hypothesis about dopamine (DA) synthesis by non-DAergic neurons expressing individual complementary enzymes of the DA synthetic pathway in cooperation, i.e. L-dihydroxyphenylalanine (L-DOPA) synthesized in tyrosine hydroxylase (TH)-expressing neurons is transported to aromatic L-amino acid decarboxylase (AADC)-expressing neurons for conversion to DA. Dopamine 50-58 dopa decarboxylase Rattus norvegicus 339-343 14980733-1 2004 This study was aimed to test our hypothesis about dopamine (DA) synthesis by non-DAergic neurons expressing individual complementary enzymes of the DA synthetic pathway in cooperation, i.e. L-dihydroxyphenylalanine (L-DOPA) synthesized in tyrosine hydroxylase (TH)-expressing neurons is transported to aromatic L-amino acid decarboxylase (AADC)-expressing neurons for conversion to DA. Dopamine 60-62 dopa decarboxylase Rattus norvegicus 311-337 14980733-1 2004 This study was aimed to test our hypothesis about dopamine (DA) synthesis by non-DAergic neurons expressing individual complementary enzymes of the DA synthetic pathway in cooperation, i.e. L-dihydroxyphenylalanine (L-DOPA) synthesized in tyrosine hydroxylase (TH)-expressing neurons is transported to aromatic L-amino acid decarboxylase (AADC)-expressing neurons for conversion to DA. Dopamine 60-62 dopa decarboxylase Rattus norvegicus 339-343 12713518-5 2003 Uninephrectomy was accompanied in W-H rats by increases in urinary levels (nmol g kidney(-1) day(-1)) of dopamine (10.3 +/- 0.5 vs. 8.3 +/- 0.7, P < 0.05) and 3,4-dihydroxyphenylacetic acid (DOPAC) (30.5 +/- 3.7 vs. 21.3 +/- 1.4, P < 0.05) and increases (P < 0.05) in maximal velocity values (Vmax in nmol mg prot(-1) 15 min(-1), 325 +/- 12 vs. 265 +/- 3) for renal aromatic L-amino acid decarboxylase (AADC), the enzyme responsible for the synthesis of renal dopamine. Dopamine 105-113 dopa decarboxylase Rattus norvegicus 412-416 12559386-1 2003 Historically, 3,4-dihydroxyphenylalanine (DOPA) has been believed to be an inert amino acid that alleviates the symptoms of Parkinson"s disease by its conversion to dopamine via the enzyme aromatic L-amino acid decarboxylase. Dopamine 165-173 dopa decarboxylase Rattus norvegicus 189-224 12676374-1 2003 Striatal neurons which are immunoreactive (ir) to aromatic L-amino-acid decarboxylase (AADC) or tyrosine hydrodroxylase (TH) may play a role in the decarboxylation of L-DOPA to dopamine (DA) in advanced stages of Parkinson"s disease (PD). Dopamine 177-185 dopa decarboxylase Rattus norvegicus 50-85 12676374-1 2003 Striatal neurons which are immunoreactive (ir) to aromatic L-amino-acid decarboxylase (AADC) or tyrosine hydrodroxylase (TH) may play a role in the decarboxylation of L-DOPA to dopamine (DA) in advanced stages of Parkinson"s disease (PD). Dopamine 177-185 dopa decarboxylase Rattus norvegicus 87-91 12676374-1 2003 Striatal neurons which are immunoreactive (ir) to aromatic L-amino-acid decarboxylase (AADC) or tyrosine hydrodroxylase (TH) may play a role in the decarboxylation of L-DOPA to dopamine (DA) in advanced stages of Parkinson"s disease (PD). Dopamine 187-189 dopa decarboxylase Rattus norvegicus 50-85 12676374-1 2003 Striatal neurons which are immunoreactive (ir) to aromatic L-amino-acid decarboxylase (AADC) or tyrosine hydrodroxylase (TH) may play a role in the decarboxylation of L-DOPA to dopamine (DA) in advanced stages of Parkinson"s disease (PD). Dopamine 187-189 dopa decarboxylase Rattus norvegicus 87-91 12358737-1 2002 Aromatic L-amino acid decarboxylase (AADC) is necessary for conversion of L-DOPA to dopamine. Dopamine 84-92 dopa decarboxylase Rattus norvegicus 0-35 12358737-1 2002 Aromatic L-amino acid decarboxylase (AADC) is necessary for conversion of L-DOPA to dopamine. Dopamine 84-92 dopa decarboxylase Rattus norvegicus 37-41 11400183-1 2001 The activity of DOPA decarboxylase measured in homogenates from rat striatum, or calculated from the rate of tracer decarboxylation measured ex vivo, is stimulated following acute treatment with antagonists of dopamine D2-like receptors. Dopamine 210-218 dopa decarboxylase Rattus norvegicus 16-34 11965353-7 2002 The above data suggest that DA could be synthesized, at least in the AN of fetuses, by monoenzymatic neurons containing either TH or AADC, in co-operation. Dopamine 28-30 dopa decarboxylase Rattus norvegicus 133-137 11965353-11 2002 Thus, DA appears to be synthesized in the AN not only by DArgic neurons but also by monoenzymatic TH- and AADC-expressing neurons in co-operation. Dopamine 6-8 dopa decarboxylase Rattus norvegicus 106-110 12047348-5 2002 These AADC neurones could uptake exogenously applied L-DOPA and formed dopamine. Dopamine 71-79 dopa decarboxylase Rattus norvegicus 6-10 11016807-17 2000 These results suggest that exercise enhances renal dopamine production by activating renal AADC activity, which in turn stimulates the renal kallikrein-kinin system. Dopamine 51-59 dopa decarboxylase Rattus norvegicus 91-95 11331406-3 2001 Using a stable aromatic amino acid decarboxylase (AADC) expressing a fibroblast cell line, we previously demonstrated a novel, non-oxidative cytotoxicity of intracellular dopamine. Dopamine 171-179 dopa decarboxylase Rattus norvegicus 50-54 11331406-4 2001 In this study, we further investigate the roles of dopamine metabolism and disposition proteins against intracellular dopamine cytotoxicity by co-expressing these factors in AADC-expressing cells. Dopamine 51-59 dopa decarboxylase Rattus norvegicus 174-178 11331406-4 2001 In this study, we further investigate the roles of dopamine metabolism and disposition proteins against intracellular dopamine cytotoxicity by co-expressing these factors in AADC-expressing cells. Dopamine 118-126 dopa decarboxylase Rattus norvegicus 174-178 11295535-2 2001 L-DOPA (L-dihydroxyphenylalanine), which is metabolized to dopamine by dopa decarboxylase, is the primary therapy for PD, but may also contribute to disease progression. Dopamine 59-67 dopa decarboxylase Rattus norvegicus 71-89 11436352-4 2001 When the aromatic L-amino acid decarboxylase (AADC) gene was added as a third gene, in an attempt to increase the conversion of L-DOPA to dopamine, feedback inhibition by the end product, dopamine, on TH activity resulted. Dopamine 138-146 dopa decarboxylase Rattus norvegicus 9-44 11436352-4 2001 When the aromatic L-amino acid decarboxylase (AADC) gene was added as a third gene, in an attempt to increase the conversion of L-DOPA to dopamine, feedback inhibition by the end product, dopamine, on TH activity resulted. Dopamine 138-146 dopa decarboxylase Rattus norvegicus 46-50 11436352-4 2001 When the aromatic L-amino acid decarboxylase (AADC) gene was added as a third gene, in an attempt to increase the conversion of L-DOPA to dopamine, feedback inhibition by the end product, dopamine, on TH activity resulted. Dopamine 188-196 dopa decarboxylase Rattus norvegicus 9-44 11436352-4 2001 When the aromatic L-amino acid decarboxylase (AADC) gene was added as a third gene, in an attempt to increase the conversion of L-DOPA to dopamine, feedback inhibition by the end product, dopamine, on TH activity resulted. Dopamine 188-196 dopa decarboxylase Rattus norvegicus 46-50 11436352-6 2001 Gene transfer of the vesicular monoamine transporter was combined with AADC and produced genetically modified cells that can convert L-DOPA to dopamine and store it for gradual release. Dopamine 143-151 dopa decarboxylase Rattus norvegicus 71-75 11097621-5 2000 15 min(-1)) for renal aromatic L-amino acid decarboxylase, the enzyme responsible for the synthesis of renal dopamine. Dopamine 109-117 dopa decarboxylase Rattus norvegicus 22-57 10869844-1 2000 In a previous study, we described a population of striatal cells in the rat brain containing aromatic L-amino acid decarboxylase, the enzyme involved in the conversion of L-DOPA into dopamine. Dopamine 183-191 dopa decarboxylase Rattus norvegicus 93-128 10619466-6 2000 Dopamine release was blocked by the centrally acting AADC inhibitor NSD 1015, but facilitated by the central AADC activator budipine. Dopamine 0-8 dopa decarboxylase Rattus norvegicus 53-57 10683850-2 2000 Dopamine synthesis was assessed in striatal slices by determining [3H]DOPA accumulation after inhibition of DOPA decarboxylase. Dopamine 0-8 dopa decarboxylase Rattus norvegicus 108-126 10584065-3 1999 The rat aromatic L-amino acid decarboxylase (AADC; EC(4.1.1.28)) catalyzes the synthesis of two important neurotransmitters: dopamine and serotonin. Dopamine 125-133 dopa decarboxylase Rattus norvegicus 8-43 10584065-3 1999 The rat aromatic L-amino acid decarboxylase (AADC; EC(4.1.1.28)) catalyzes the synthesis of two important neurotransmitters: dopamine and serotonin. Dopamine 125-133 dopa decarboxylase Rattus norvegicus 45-49 9710269-6 1998 The results suggest that the stimulation of AADC mRNA by amantadine may be one of its effects on dopamine metabolism that may have relevance for potentiation of L-Dopa therapy in Parkinsonism. Dopamine 97-105 dopa decarboxylase Rattus norvegicus 44-48 10191339-0 1999 Vesicular monoamine transporter-2 and aromatic L-amino acid decarboxylase enhance dopamine delivery after L-3, 4-dihydroxyphenylalanine administration in Parkinsonian rats. Dopamine 82-90 dopa decarboxylase Rattus norvegicus 47-73 9853519-3 1998 Tyrosine hydroxylase (TH) catalyzes the synthesis of L-dopa, which must be converted to dopamine by aromatic L-amino acid decarboxylase (AADC). Dopamine 88-96 dopa decarboxylase Rattus norvegicus 109-135 9853519-3 1998 Tyrosine hydroxylase (TH) catalyzes the synthesis of L-dopa, which must be converted to dopamine by aromatic L-amino acid decarboxylase (AADC). Dopamine 88-96 dopa decarboxylase Rattus norvegicus 137-141 9853519-4 1998 Since the endogenous AADC activity in the striatum is considered to be low, coexpression of both TH and AADC in the same striatal cells would increase the dopamine production and thereby augment the therapeutic effects. Dopamine 155-163 dopa decarboxylase Rattus norvegicus 104-108 9593857-0 1998 Differential effects of NMDA and non-NMDA antagonists on the activity of aromatic L-amino acid decarboxylase activity in the nigrostriatal dopamine pathway of the rat. Dopamine 139-147 dopa decarboxylase Rattus norvegicus 73-108 9591841-1 1998 Tyrosine hydroxylase of catecholamine neurons catalyzes the synthesis of 3,4-dihydroxphenylalanine (DOPA), which is subsequently metabolized to dopamine by DOPA decarboxylase (DDC). Dopamine 144-152 dopa decarboxylase Rattus norvegicus 156-174 9591841-1 1998 Tyrosine hydroxylase of catecholamine neurons catalyzes the synthesis of 3,4-dihydroxphenylalanine (DOPA), which is subsequently metabolized to dopamine by DOPA decarboxylase (DDC). Dopamine 144-152 dopa decarboxylase Rattus norvegicus 176-179 9591841-7 1998 The rate constant for the clearance of DOPA from brain (0.06 min(-1)) and earlier estimates of the rate constant of DDC activity in striatum (0.26 min(-1)) together predict that 80% of DOPA formed in normal rat striatum normally is available for dopamine synthesis. Dopamine 246-254 dopa decarboxylase Rattus norvegicus 116-119 9349551-6 1997 Grafts containing aromatic L-amino acid decarboxylase produced less L-DOPA and dopamine as monitored by microdialysis. Dopamine 79-87 dopa decarboxylase Rattus norvegicus 18-53 9871440-1 1998 This study examines the hypothesis that glutamate tonically suppresses the activity of the enzyme aromatic L-amino acid decarboxylase (AADC), and hence the biosynthesis of dopamine, to explain how antagonists of glutamate receptors might potentiale the motor actions of L-DOPA in animal models of Parkinson"s disease. Dopamine 172-180 dopa decarboxylase Rattus norvegicus 98-133 9871440-1 1998 This study examines the hypothesis that glutamate tonically suppresses the activity of the enzyme aromatic L-amino acid decarboxylase (AADC), and hence the biosynthesis of dopamine, to explain how antagonists of glutamate receptors might potentiale the motor actions of L-DOPA in animal models of Parkinson"s disease. Dopamine 172-180 dopa decarboxylase Rattus norvegicus 135-139 9349551-0 1997 Role of aromatic L-amino acid decarboxylase for dopamine replacement by genetically modified fibroblasts in a rat model of Parkinson"s disease. Dopamine 48-56 dopa decarboxylase Rattus norvegicus 8-43 9137906-5 1997 As DDC is an enzyme specifically involved in catecholamine synthesis, insular cells must possess the capacity to elaborate this class of hormone at least up to the dopamine-decarboxylation step. Dopamine 164-172 dopa decarboxylase Rattus norvegicus 3-6 7570352-6 1995 Twenty-four hours after cessation of treatment, dopamine synthesis, measured as accumulation of 3,4-dihydroxyphenylalanine (DOPA) after treatment with the DOPA decarboxylase inhibitor NSD-1015, was enhanced in the striatum, but not nucleus accumbens-olfactory tubercle (NAOT) or ventral mesencephalon (VM). Dopamine 48-56 dopa decarboxylase Rattus norvegicus 155-173 9057138-1 1997 Aromatic L-amino acid decarboxylase (AADC) and tyrosine hydroxylase (TH) are involved in the synthesis of dopamine and other monoamine neurotransmitters, and their activities can be regulated by a number of physiological stimuli. Dopamine 106-114 dopa decarboxylase Rattus norvegicus 0-35 9057138-1 1997 Aromatic L-amino acid decarboxylase (AADC) and tyrosine hydroxylase (TH) are involved in the synthesis of dopamine and other monoamine neurotransmitters, and their activities can be regulated by a number of physiological stimuli. Dopamine 106-114 dopa decarboxylase Rattus norvegicus 37-41 8750961-1 1995 The efficacy of L-dihydroxyphenylalanine (L-DOPA) in ameliorating the symptoms of Parkinson"s disease (PD) is attributed to its conversion to dopamine (DA) by the enzyme aromatic L-amino-acid decarboxylase (AADC) in the striatum. Dopamine 142-150 dopa decarboxylase Rattus norvegicus 170-205 8750961-1 1995 The efficacy of L-dihydroxyphenylalanine (L-DOPA) in ameliorating the symptoms of Parkinson"s disease (PD) is attributed to its conversion to dopamine (DA) by the enzyme aromatic L-amino-acid decarboxylase (AADC) in the striatum. Dopamine 142-150 dopa decarboxylase Rattus norvegicus 207-211 8750961-1 1995 The efficacy of L-dihydroxyphenylalanine (L-DOPA) in ameliorating the symptoms of Parkinson"s disease (PD) is attributed to its conversion to dopamine (DA) by the enzyme aromatic L-amino-acid decarboxylase (AADC) in the striatum. Dopamine 152-154 dopa decarboxylase Rattus norvegicus 170-205 8750961-1 1995 The efficacy of L-dihydroxyphenylalanine (L-DOPA) in ameliorating the symptoms of Parkinson"s disease (PD) is attributed to its conversion to dopamine (DA) by the enzyme aromatic L-amino-acid decarboxylase (AADC) in the striatum. Dopamine 152-154 dopa decarboxylase Rattus norvegicus 207-211 7643116-1 1995 To test the hypothesis that L-DOPA decarboxylase (DDC) is a regulated enzyme in the synthesis of dopamine (DA), we developed a model of the cerebral uptake and metabolism of [3H]DOPA. Dopamine 97-105 dopa decarboxylase Rattus norvegicus 28-48 7643116-1 1995 To test the hypothesis that L-DOPA decarboxylase (DDC) is a regulated enzyme in the synthesis of dopamine (DA), we developed a model of the cerebral uptake and metabolism of [3H]DOPA. Dopamine 97-105 dopa decarboxylase Rattus norvegicus 50-53 7643116-1 1995 To test the hypothesis that L-DOPA decarboxylase (DDC) is a regulated enzyme in the synthesis of dopamine (DA), we developed a model of the cerebral uptake and metabolism of [3H]DOPA. Dopamine 107-109 dopa decarboxylase Rattus norvegicus 28-48 7643116-1 1995 To test the hypothesis that L-DOPA decarboxylase (DDC) is a regulated enzyme in the synthesis of dopamine (DA), we developed a model of the cerebral uptake and metabolism of [3H]DOPA. Dopamine 107-109 dopa decarboxylase Rattus norvegicus 50-53 7643116-8 1995 Thus, DDC activity may be a regulated step in the synthesis of DA. Dopamine 63-65 dopa decarboxylase Rattus norvegicus 6-9 7673270-3 1995 Endogenous DA levels were increased through the infusion of its precursor levodopa (LD) (0.5 or 1 microM) whereas benserazide (50 or 100 microM), an inhibitor of the enzyme L-dopa-decarboxylase, was used to decrease DA synthesis. Dopamine 11-13 dopa decarboxylase Rattus norvegicus 173-193 7541690-20 1995 In conclusion, the present studies show that the hypertensive response resulting from the long-term administration of L-NAME is accompanied by an increased urinary excretion of dopamine and 5-hydroxytryptamine, which appears to follow an enhanced activity of renal AAAD. Dopamine 177-185 dopa decarboxylase Rattus norvegicus 265-269 7697371-1 1994 The aim of the present study is to examine whether aromatic L-amino acid decarboxylase (AADC) catalyzes the conversion of exogenous L-3,4-dihydroxyphenylalanine (L-DOPA) to dopamine in serotonin neurons of the rat dorsal raphe nucleus. Dopamine 173-181 dopa decarboxylase Rattus norvegicus 60-86 7697371-1 1994 The aim of the present study is to examine whether aromatic L-amino acid decarboxylase (AADC) catalyzes the conversion of exogenous L-3,4-dihydroxyphenylalanine (L-DOPA) to dopamine in serotonin neurons of the rat dorsal raphe nucleus. Dopamine 173-181 dopa decarboxylase Rattus norvegicus 88-92 7913379-16 1994 These studies show that striatal synaptosomal AADC activity is regulated by dopamine receptors and indicate that in vitro dopamine DI and D2 receptors have a synergistic effect in this regulation. Dopamine 76-84 dopa decarboxylase Rattus norvegicus 46-50 8065515-1 1994 Aromatic 1-amino acid decarboxylase (AADC) is involved in the synthesis of the putative neurotransmitters dopamine (DA), norepinephrine (NA) and 5-hydroxytryptamine (5-HT). Dopamine 106-114 dopa decarboxylase Rattus norvegicus 37-41 8065515-1 1994 Aromatic 1-amino acid decarboxylase (AADC) is involved in the synthesis of the putative neurotransmitters dopamine (DA), norepinephrine (NA) and 5-hydroxytryptamine (5-HT). Dopamine 116-118 dopa decarboxylase Rattus norvegicus 37-41 8510830-1 1993 Aromatic L-amino acid decarboxylase (AADC) decarboxylates L-DOPA and 5-hydroxytryptophan into dopamine and serotonin, respectively. Dopamine 94-102 dopa decarboxylase Rattus norvegicus 0-35 7902865-6 1993 The feasibility of regulating the final dopamine production by the AADC-transduced cells was explored in two ways. Dopamine 40-48 dopa decarboxylase Rattus norvegicus 67-71 7902865-8 1993 Second, coculturing AADC-transduced cells with TH-transduced cells in various proportions allowed control of dopamine production. Dopamine 109-117 dopa decarboxylase Rattus norvegicus 20-24 8371833-1 1993 Aromatic L-amino acid decarboxylase (AADC) is involved in the synthesis of the putative neurotransmitters dopamine (DA), 5-hydroxytryptamine (5-HT), and trace amines some of which have been proposed as neuromodulators, such as 2-phenylethylamine and tryptamine. Dopamine 106-114 dopa decarboxylase Rattus norvegicus 0-35 8371833-1 1993 Aromatic L-amino acid decarboxylase (AADC) is involved in the synthesis of the putative neurotransmitters dopamine (DA), 5-hydroxytryptamine (5-HT), and trace amines some of which have been proposed as neuromodulators, such as 2-phenylethylamine and tryptamine. Dopamine 106-114 dopa decarboxylase Rattus norvegicus 37-41 8371833-1 1993 Aromatic L-amino acid decarboxylase (AADC) is involved in the synthesis of the putative neurotransmitters dopamine (DA), 5-hydroxytryptamine (5-HT), and trace amines some of which have been proposed as neuromodulators, such as 2-phenylethylamine and tryptamine. Dopamine 116-118 dopa decarboxylase Rattus norvegicus 0-35 8371833-1 1993 Aromatic L-amino acid decarboxylase (AADC) is involved in the synthesis of the putative neurotransmitters dopamine (DA), 5-hydroxytryptamine (5-HT), and trace amines some of which have been proposed as neuromodulators, such as 2-phenylethylamine and tryptamine. Dopamine 116-118 dopa decarboxylase Rattus norvegicus 37-41 8494538-10 1993 It is concluded that the increased activity of AAAD in renal tissues of rats submitted to HS intake is accompanied in "1 week HS" but not in "6 weeks HS" rats by enhanced inhibition of dopamine formation during protein kinase C activation. Dopamine 185-193 dopa decarboxylase Rattus norvegicus 47-51 8510830-1 1993 Aromatic L-amino acid decarboxylase (AADC) decarboxylates L-DOPA and 5-hydroxytryptophan into dopamine and serotonin, respectively. Dopamine 94-102 dopa decarboxylase Rattus norvegicus 37-41 8436958-1 1993 Aromatic L-amino acid decarboxylase catalyzes the biosynthesis of the neurotransmitters dopamine and serotonin. Dopamine 88-96 dopa decarboxylase Rattus norvegicus 0-35 8095184-5 1993 Many but not all of the tyrosine hydroxylase-immunoreactive neurons are also immunoreactive to the dopamine synthesizing enzyme, aromatic-L-amino-acid-decarboxylase, but lack the noradrenaline-synthesizing enzyme, dopamine-beta-hydroxylase, thus favoring synthesis of dopamine. Dopamine 99-107 dopa decarboxylase Rattus norvegicus 129-164 1405340-2 1992 Proximal tubule cells produce dopamine after decarboxylation of L-DOPA via the enzyme aromatic L-amino acid decarboxylase (AADC). Dopamine 30-38 dopa decarboxylase Rattus norvegicus 95-121 1465439-1 1992 Aromatic L-amino acid decarboxylase (AADC, EC 4.1.1.28) catalyzes the decarboxylation of L-dopa to dopamine in catecholamine cells and 5-hydroxytryptophan to serotonin in serotonin-producing neurons. Dopamine 99-107 dopa decarboxylase Rattus norvegicus 0-35 1465439-1 1992 Aromatic L-amino acid decarboxylase (AADC, EC 4.1.1.28) catalyzes the decarboxylation of L-dopa to dopamine in catecholamine cells and 5-hydroxytryptophan to serotonin in serotonin-producing neurons. Dopamine 99-107 dopa decarboxylase Rattus norvegicus 37-41 1405340-2 1992 Proximal tubule cells produce dopamine after decarboxylation of L-DOPA via the enzyme aromatic L-amino acid decarboxylase (AADC). Dopamine 30-38 dopa decarboxylase Rattus norvegicus 123-127 1319782-3 1992 Treatment with L-dopa/decarboxylase inhibitor reversed the suppressing effect of quinolinic acid on dopamine, but not on noradrenaline. Dopamine 100-108 dopa decarboxylase Rattus norvegicus 15-35 1357712-5 1992 These results indicate that DDC may be more important than TH in the long term regulation of dopamine production. Dopamine 93-101 dopa decarboxylase Rattus norvegicus 28-31 1729407-1 1992 Decarboxylation of phenylalanine by aromatic L-amino acid decarboxylase (AADC) is the rate-limiting step in the synthesis of 2-phenylethylamine (PE), a putative modulator of dopamine transmission. Dopamine 174-182 dopa decarboxylase Rattus norvegicus 45-71 1729407-1 1992 Decarboxylation of phenylalanine by aromatic L-amino acid decarboxylase (AADC) is the rate-limiting step in the synthesis of 2-phenylethylamine (PE), a putative modulator of dopamine transmission. Dopamine 174-182 dopa decarboxylase Rattus norvegicus 73-77 1681739-9 1991 AADC inhibitors and DA2 antagonists also lowered basal PGE2 levels, suggesting that dopamine was being formed constitutively in culture. Dopamine 84-92 dopa decarboxylase Rattus norvegicus 0-4 1801681-8 1991 These results suggest that fetal plasma L-dopa may be converted to dopamine by fetal kidney DDC, and that the dopamine is voided into the amniotic cavity in fetal urine. Dopamine 67-75 dopa decarboxylase Rattus norvegicus 92-95 1797228-1 1991 Aromatic L-amino acid decarboxylase (AADC) is responsible for the conversion of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are important neurotransmitters. Dopamine 147-155 dopa decarboxylase Rattus norvegicus 0-35 1680579-3 1991 Chronic treatment of cells by dopamine or apomorphine (a mixed D1/D2 agonist), but not selective D1 and D2 agonists, significantly increased the number of cells that expressed tyrosine hydroxylase (TH: as assessed with a specific anti-TH antiserum) and the activity of aromatic L-amino acid decarboxylase (AADC) in the cultures. Dopamine 30-38 dopa decarboxylase Rattus norvegicus 278-304 1680579-3 1991 Chronic treatment of cells by dopamine or apomorphine (a mixed D1/D2 agonist), but not selective D1 and D2 agonists, significantly increased the number of cells that expressed tyrosine hydroxylase (TH: as assessed with a specific anti-TH antiserum) and the activity of aromatic L-amino acid decarboxylase (AADC) in the cultures. Dopamine 30-38 dopa decarboxylase Rattus norvegicus 306-310 1680579-6 1991 Furthermore both the expression and the dopamine-induced modulation of AADC activity and TH immunoreactivity appeared to occur independently of each other. Dopamine 40-48 dopa decarboxylase Rattus norvegicus 71-75 1797228-1 1991 Aromatic L-amino acid decarboxylase (AADC) is responsible for the conversion of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are important neurotransmitters. Dopamine 147-155 dopa decarboxylase Rattus norvegicus 37-41 2120607-2 1990 Dopamine synthesis in and release from TIDA neurons were determined in vitro by 3,4-dihydroxyphenylalanine (DOPA) accumulation in the median eminence following incubation with a DOPA decarboxylase inhibitor and endogenous dopamine release from the median eminence, respectively. Dopamine 0-8 dopa decarboxylase Rattus norvegicus 178-196 2033120-1 1991 Aromatic L-amino acid decarboxylase (AADC), the enzyme that converts L-dopa to dopamine, displayed species-specific differences in both activity and immunoreactivity in the cerebellum, olfactory bulb, and adrenal glands of three rodent species, the hamster, rat, and mouse. Dopamine 79-87 dopa decarboxylase Rattus norvegicus 0-35 2081822-1 1990 By indirect immunohistochemistry, the present study examined the distribution of neuronal structures in the cat medulla oblongata, pons, and midbrain, showing immunoreactivity to aromatic L-amino acid decarboxylase (AADC), which catalyzes the conversion of L-3, 4-dihydroxyphenylalanine (L-DOPA) to dopamine, and 5-hydroxytryptophan to serotonin (5HT). Dopamine 299-307 dopa decarboxylase Rattus norvegicus 188-214 2081822-1 1990 By indirect immunohistochemistry, the present study examined the distribution of neuronal structures in the cat medulla oblongata, pons, and midbrain, showing immunoreactivity to aromatic L-amino acid decarboxylase (AADC), which catalyzes the conversion of L-3, 4-dihydroxyphenylalanine (L-DOPA) to dopamine, and 5-hydroxytryptophan to serotonin (5HT). Dopamine 299-307 dopa decarboxylase Rattus norvegicus 216-220 2154126-1 1990 The enzyme L-amino acid decarboxylase (L-AADC), found in abundance in rat proximal tubule cell cytosol, converts L-dopa to dopamine. Dopamine 123-131 dopa decarboxylase Rattus norvegicus 41-45 1972967-1 1990 Gamma-L-glutamyl-L-dopa (or gludopa), a dopamine (DA) prodrug, is selectively metabolized in vivo by the kidney through the sequential action of two renal enzymes, gamma-glutamyl transpeptidase (gamma-GT) and aromatic L-amino acid decarboxylase (AADC). Dopamine 50-52 dopa decarboxylase Rattus norvegicus 218-244 1972967-1 1990 Gamma-L-glutamyl-L-dopa (or gludopa), a dopamine (DA) prodrug, is selectively metabolized in vivo by the kidney through the sequential action of two renal enzymes, gamma-glutamyl transpeptidase (gamma-GT) and aromatic L-amino acid decarboxylase (AADC). Dopamine 50-52 dopa decarboxylase Rattus norvegicus 246-250 2137529-7 1990 We suggest that dopamine released in the dark tonically occupies D1 receptors and suppresses AAAD activity. Dopamine 16-24 dopa decarboxylase Rattus norvegicus 93-97 2301593-1 1990 Extraneural dopamine is thought to be synthesized by an aromatic L-amino acid decarboxylase (L-AADC) activity in tubular cells. Dopamine 12-20 dopa decarboxylase Rattus norvegicus 56-91 34313482-3 2021 Treatment with L-dihydroxyphenylalanine, not tyrosine, caused the production of dopamine in the incubation of INS-1 cells (rat islet beta cell line) and primary isolated islets, which was blocked by AADC inhibitor NSD-1015. Dopamine 80-88 dopa decarboxylase Rattus norvegicus 199-203 3151164-14 1988 These data raise the possibility that dopamine and 5-hydroxytryptamine are formed as reciprocal intrarenal hormones by the identical enzyme, aromatic L-amino-acid decarboxylase, which is located within cells of the renal tubule. Dopamine 38-46 dopa decarboxylase Rattus norvegicus 141-176 3135174-2 1988 Dopamine synthesis in vitro in TIDA neurons was estimated by 3,4-dihydroxyphenylalanine (DOPA) accumulation in the median eminence after incubation of slices with a DOPA decarboxylase inhibitor. Dopamine 0-8 dopa decarboxylase Rattus norvegicus 165-183 3875501-5 1985 These results, indicating that pyridoxine deficiency has differential effects on the activity of AADC, are consistent with our earlier observation of non-parallel changes in dopamine and serotonin content in various brain regions of the pyridoxine-deficient rat. Dopamine 174-182 dopa decarboxylase Rattus norvegicus 97-101 3141816-0 1988 NSD 1034: an amino acid decarboxylase inhibitor with a stimulatory action on dopamine synthesis not mediated by classical dopamine receptors. Dopamine 77-85 dopa decarboxylase Rattus norvegicus 13-37 3141816-3 1988 This discrepancy prompted us to further investigate the AADC inhibitor 1-(3-hydroxybenzyl)-1-methylhydrazine (NSD 1034) which earlier has been shown to give a DOPA accumulation rate in the striatum of the same magnitude as other measures of DA turnover. Dopamine 241-243 dopa decarboxylase Rattus norvegicus 56-60 2837907-8 1988 Benserazide (Bz), an inhibitor of the enzyme L-aromatic amino acid decarboxylase (AADC) that converts L-dopa to DA, significantly attenuated the natriuresis in HS rats but had no effect on GFR. Dopamine 112-114 dopa decarboxylase Rattus norvegicus 82-86 3126532-2 1988 Lithium treatment also resulted in an increase in the activity of tuberoinfundibular dopaminergic neurons, as evidenced by an increased accumulation of dihydroxyphenylalanine (DOPA) in the median eminence after inhibition of DOPA decarboxylase and an increased concentration of dopamine in the anterior pituitary gland. Dopamine 85-93 dopa decarboxylase Rattus norvegicus 225-243 3677450-6 1987 In absence of L-DOPA or in presence of DOPA decarboxylase inhibitors, DA production was suppressed. Dopamine 70-72 dopa decarboxylase Rattus norvegicus 39-57 4023392-2 1985 Urinary dopamine excretion was not diminished by sympathectomy, was increased by l-dopa (but not tyrosine or dopamine 4-O-sulphate) in the perfusate and was virtually abolished by prior treatment with the dopa decarboxylase inhibitor, carbidopa. Dopamine 8-16 dopa decarboxylase Rattus norvegicus 205-223 6504328-1 1984 Dopamine (DA) elevations in rat striatum produced by combined administration of L-dopa and carbidopa were abolished when L-dopa was injected with NSD-1015, an inhibitor of central dopa-decarboxylase. Dopamine 0-8 dopa decarboxylase Rattus norvegicus 180-198 6504328-1 1984 Dopamine (DA) elevations in rat striatum produced by combined administration of L-dopa and carbidopa were abolished when L-dopa was injected with NSD-1015, an inhibitor of central dopa-decarboxylase. Dopamine 10-12 dopa decarboxylase Rattus norvegicus 180-198 6433718-4 1984 Carbidopa, a dopa decarboxylase blocker, added to the perfusate markedly reduced the urinary excretion of dopamine. Dopamine 106-114 dopa decarboxylase Rattus norvegicus 13-31 6205316-3 1984 It has been assumed, based on indirect evidence, that aromatic L-amino acid decarboxylase (L-AAD), the enzyme responsible for the conversion of L-5-hydroxytryptophan (5-HTP) to 5-HT as well as L-3,4-dihydroxyphenylalanine (L-dopa) to dopamine (DA), is ubiquitously distributed in most tissues of the body including the AP. Dopamine 234-242 dopa decarboxylase Rattus norvegicus 54-89 6205316-3 1984 It has been assumed, based on indirect evidence, that aromatic L-amino acid decarboxylase (L-AAD), the enzyme responsible for the conversion of L-5-hydroxytryptophan (5-HTP) to 5-HT as well as L-3,4-dihydroxyphenylalanine (L-dopa) to dopamine (DA), is ubiquitously distributed in most tissues of the body including the AP. Dopamine 244-246 dopa decarboxylase Rattus norvegicus 54-89 6433718-8 1984 These data indicate that urinary free dopamine is mainly derived from plasma dopa, which is converted by dopa decarboxylase in the kidney. Dopamine 38-46 dopa decarboxylase Rattus norvegicus 105-123 6811255-3 1982 The reduction in the concentration of dopamine in the plasma of blood from a single hypophysial portal vessel after the inhibition of DOPA decarboxylase activity was associated with a concomitant increase in the concentration of PRL in the plasma of arterial blood. Dopamine 38-46 dopa decarboxylase Rattus norvegicus 134-152 6371583-5 1984 Dopamine, noradrenaline, and adrenaline cells exhibited characteristic staining intensities to anti-aromatic L-amino acid decarboxylase reflective of relative enzyme levels in the different groups. Dopamine 0-8 dopa decarboxylase Rattus norvegicus 100-135 6135575-8 1983 Although AADC inhibition reduced the magnitude of the increases in serum dopamine levels following L-DOPA administration, no reduction in serum 3,4-dihydroxyphenylacetic acid levels was observed. Dopamine 73-81 dopa decarboxylase Rattus norvegicus 9-13 6420514-1 1983 Following interruption of the nerve impulse flow in the dopamine neurons by treatment with gammabutyrolactone, the selective dopamine autoreceptor agonist B-HT 920 reduced the DOPA accumulation after DOPA decarboxylase inhibition and the 3,4-dihydroxyphenylacetic acid concentration in the corpus striatum, the nucleus accumbens, the olfactory tubercle, the limbic cortex and the rostral part of the cerebral cortex of rats. Dopamine 125-133 dopa decarboxylase Rattus norvegicus 200-218 7106369-12 1982 Cortical slices prepared from rats treated by benserazide, an inhibitor of L-DOPA decarboxylase, synthesized much less dopamine than those from control rats. Dopamine 119-127 dopa decarboxylase Rattus norvegicus 75-95 16685-5 1977 In the principal bulb the first two enzymes, tyrosine hydroxylase (TH) and DOPA decarboxylase (DDC), but not dopamine-beta-hydroxylase (DBH), were present in a proportion of periglomerular cell bodies and dendrites indicating that these neurons synthesize dopamine (DA). Dopamine 266-268 dopa decarboxylase Rattus norvegicus 75-93 7205652-1 1981 Unilateral nigrostriatal lesions produced by injecting 6-hydroxydopamine stereotaxically into both the substantia nigra and the medial forebrain bundle reduced striatal tyrosine hydroxylase activity and dopamine (DA) concentrations by 95% (compared with the intact, contralateral striata) but lowered dopa decarboxylase (DDC) activity by only 80%. Dopamine 64-72 dopa decarboxylase Rattus norvegicus 301-319 7205652-1 1981 Unilateral nigrostriatal lesions produced by injecting 6-hydroxydopamine stereotaxically into both the substantia nigra and the medial forebrain bundle reduced striatal tyrosine hydroxylase activity and dopamine (DA) concentrations by 95% (compared with the intact, contralateral striata) but lowered dopa decarboxylase (DDC) activity by only 80%. Dopamine 64-72 dopa decarboxylase Rattus norvegicus 321-324 7407592-1 1980 In rats with unilateral nigrostriatal lesions, L-DOPA-induced dopamine increases in ipsilateral striata were further enhanced after inhibition of DOPA decarboxylase in cerebral microvessels by carbidopa. Dopamine 62-70 dopa decarboxylase Rattus norvegicus 146-164 5289371-3 1971 In the present study, it was found that when L-dopa was administered to rats, the activity of liver aromatic L-amino-acid decarboxylase, the enzyme which catalyzes the conversion of dopa to dopamine, was reduced by as much as 50%. Dopamine 190-198 dopa decarboxylase Rattus norvegicus 100-135 241812-3 1975 Changes in striatal dopamine metabolism were estimated by following either the accumulation of [3H] dopamine 15 min after intravenous injection of [3H] tyrosine or the accumulation of dopa (taken as an index of dopamine synthesis) in animals pretreated with a dopa decarboxylase inhibitor Ro4-4602. Dopamine 20-28 dopa decarboxylase Rattus norvegicus 260-278 241812-8 1975 The accumulation of dopa was not modified there being no difference from the saline value in animals pretreated with the dopa decarboxylase inhibitor at high dopamine metabolism and atropine reduced dopamine utilization. Dopamine 158-166 dopa decarboxylase Rattus norvegicus 121-139 4121370-0 1973 Immunohistochemical localization of aromatic L-amino acid decarboxylase (DOPA decarboxylase) in central dopamine and 5-hydroxytryptamine nerve cell bodies of the rat. Dopamine 104-112 dopa decarboxylase Rattus norvegicus 36-71 4121370-0 1973 Immunohistochemical localization of aromatic L-amino acid decarboxylase (DOPA decarboxylase) in central dopamine and 5-hydroxytryptamine nerve cell bodies of the rat. Dopamine 104-112 dopa decarboxylase Rattus norvegicus 73-91