PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25899596-3 2015 This F-DOPA PET phenomenon possibly represents elevated presynaptic dopamine function secondary to upregulation of the amino acid decarboxylase (AADC) activity, as a compensatory mechanism in response to cortical injury. Dopamine 68-76 dopa decarboxylase Homo sapiens 145-149 26439947-3 2016 Presynaptic dopaminergic dysfunction in PD can be revealed through the imaging of different steps in the process of dopamine synthesis and storage: L-aromatic amino acid decarboxylase (AADC) activity, Vesicular Monoamine Transporter type 2 (VMAT2) binding or its reuptake via the dopamine transporter (DAT). Dopamine 12-20 dopa decarboxylase Homo sapiens 185-189 27025882-3 2016 LDOPA increases synaptic dopamine, while the inhibitor of peripheral DOPA decarboxylase reduces the conversion of L-DOPA to dopamine in the systemic circulation, allowing for greater L-DOPA distribution into the central nervous system. Dopamine 124-132 dopa decarboxylase Homo sapiens 69-87 25445287-1 2015 l-DOPA decarboxylase (DDC) is a multiply-regulated gene which encodes the enzyme that catalyzes the biosynthesis of dopamine in humans. Dopamine 116-124 dopa decarboxylase Homo sapiens 0-20 25721989-3 2015 L-DOPA decarboxylase (DDC) is the gene encoding the enzyme that catalyzes the biosynthesis of dopamine in humans. Dopamine 94-102 dopa decarboxylase Homo sapiens 0-20 25721989-3 2015 L-DOPA decarboxylase (DDC) is the gene encoding the enzyme that catalyzes the biosynthesis of dopamine in humans. Dopamine 94-102 dopa decarboxylase Homo sapiens 22-25 25956449-1 2015 Aromatic L-amino acid decarboxylase (AADC) deficiency is an inborn error of metabolism affecting the biosynthesis of serotonin, dopamine, and catecholamines. Dopamine 128-136 dopa decarboxylase Homo sapiens 0-35 25956449-1 2015 Aromatic L-amino acid decarboxylase (AADC) deficiency is an inborn error of metabolism affecting the biosynthesis of serotonin, dopamine, and catecholamines. Dopamine 128-136 dopa decarboxylase Homo sapiens 37-41 25445287-1 2015 l-DOPA decarboxylase (DDC) is a multiply-regulated gene which encodes the enzyme that catalyzes the biosynthesis of dopamine in humans. Dopamine 116-124 dopa decarboxylase Homo sapiens 22-25 24865461-1 2014 Dopa decarboxylase (DDC), or aromatic amino acid decarboxylase (AADC), is a pyridoxal 5"-phosphate enzyme responsible for the production of the neurotransmitters dopamine and serotonin. Dopamine 162-170 dopa decarboxylase Homo sapiens 0-18 25303896-10 2014 Droxidopa is a synthetic amino acid that is converted to norepinephrine by dopa-decarboxylase, the same enzyme that converts levodopa into dopamine in the treatment of Parkinson disease. Dopamine 139-147 dopa decarboxylase Homo sapiens 75-93 24865461-1 2014 Dopa decarboxylase (DDC), or aromatic amino acid decarboxylase (AADC), is a pyridoxal 5"-phosphate enzyme responsible for the production of the neurotransmitters dopamine and serotonin. Dopamine 162-170 dopa decarboxylase Homo sapiens 64-68 24037885-6 2013 Indeed, these results indicated an aromatic L-amino acid decarboxylase deficiency that impairs the synthesis of serotonin, dopamine, and catecholamines. Dopamine 123-131 dopa decarboxylase Homo sapiens 35-70 25024584-1 2014 Aromatic L-amino acid decarboxylase (AADC), a vitamin B6-requiring enzyme that converts L-dopa to dopamine and 5-hydroxytryptophan to serotonin. Dopamine 98-106 dopa decarboxylase Homo sapiens 37-41 24216088-2 2014 The major pathway for dopamine synthesis from L-dopa is decarboxylation by aromatic L-amino acid decarboxylase (AAAD, encoded by the DDC gene). Dopamine 22-30 dopa decarboxylase Homo sapiens 75-110 24216088-2 2014 The major pathway for dopamine synthesis from L-dopa is decarboxylation by aromatic L-amino acid decarboxylase (AAAD, encoded by the DDC gene). Dopamine 22-30 dopa decarboxylase Homo sapiens 112-116 24216088-2 2014 The major pathway for dopamine synthesis from L-dopa is decarboxylation by aromatic L-amino acid decarboxylase (AAAD, encoded by the DDC gene). Dopamine 22-30 dopa decarboxylase Homo sapiens 133-136 24216088-10 2014 DISCUSSION: The rs921451 and rs3837091 polymorphisms of the DDC gene promoter influence the motor response to L-dopa but do not significantly change peripheral pharmacokinetic parameters for L-dopa and dopamine. Dopamine 202-210 dopa decarboxylase Homo sapiens 60-63 25175964-1 2014 Dopamine replacement therapy using the dopamine precursor, l-3,4-dihydroxyphenylalanine (l-DOPA), with a peripheral dopa decarboxylase inhibitor is the most effective treatment currently available for the symptoms of Parkinson"s disease (PD). Dopamine 0-8 dopa decarboxylase Homo sapiens 116-134 24471650-1 2014 Dopamine, a biogenic amine with important biological functions, is produced from l-DOPA by DOPA decarboxylase (DDC). Dopamine 0-8 dopa decarboxylase Homo sapiens 91-109 24471650-1 2014 Dopamine, a biogenic amine with important biological functions, is produced from l-DOPA by DOPA decarboxylase (DDC). Dopamine 0-8 dopa decarboxylase Homo sapiens 111-114 24471650-2 2014 DDC is a potential target to modulate the production of dopamine in several pathological states. Dopamine 56-64 dopa decarboxylase Homo sapiens 0-3 24471650-10 2014 The natural-product-based selective inhibitors of hDDC could serve as a chemical lead for developing improved drugs for dopamine-related disease states. Dopamine 120-128 dopa decarboxylase Homo sapiens 50-54 24407024-1 2014 Mammalian Dopa decarboxylase catalyzes the conversion of L-Dopa and L-5-hydroxytryptophan to dopamine and serotonin, respectively. Dopamine 93-101 dopa decarboxylase Homo sapiens 10-28 23276884-1 2013 DOPA decarboxylase (DDC) is involved in the synthesis of dopamine, norepinephrine and serotonin. Dopamine 57-65 dopa decarboxylase Homo sapiens 0-18 23276884-1 2013 DOPA decarboxylase (DDC) is involved in the synthesis of dopamine, norepinephrine and serotonin. Dopamine 57-65 dopa decarboxylase Homo sapiens 20-23 24054140-6 2013 It means that l-3,4-dihydroxyphenylalanine (l-DOPA) synthesized from l-tyrosine in monoenzymatic TH neurons is transported to monoenzymatic AADC neurons for DA synthesis. Dopamine 157-159 dopa decarboxylase Homo sapiens 140-144 23553478-1 2013 OBJECTIVE: The purpose of this study was to determine whether carbidopa (Lodosyn), an inhibitor of dopa-decarboxylase that blocks the synthesis of dopamine outside the brain, is an effective antiemetic in patients with familial dysautonomia (FD) and hyperdopaminergic nausea/retching/vomiting attacks. Dopamine 147-155 dopa decarboxylase Homo sapiens 99-117 23321058-1 2013 Dopa or aromatic amino acid decarboxylase (DDC, AADC) is a pyridoxal 5"-phosphate-dependent enzyme that catalyses the production of the neurotransmitters dopamine and serotonin. Dopamine 154-162 dopa decarboxylase Homo sapiens 48-52 23261515-2 2013 Dopamine is produced first by hydroxylalation of l-tyrosine to l-dihydroxyphenylalanine (l-dopa) and subsequently by the decarboxylation of l-dopa to dopamine catalysed by the enzymes tyrosine hydroxylase and aromatic l-amino acid decarboxylase (AADC) respectively. Dopamine 0-8 dopa decarboxylase Homo sapiens 209-244 23261515-2 2013 Dopamine is produced first by hydroxylalation of l-tyrosine to l-dihydroxyphenylalanine (l-dopa) and subsequently by the decarboxylation of l-dopa to dopamine catalysed by the enzymes tyrosine hydroxylase and aromatic l-amino acid decarboxylase (AADC) respectively. Dopamine 0-8 dopa decarboxylase Homo sapiens 246-250 24054149-1 2013 Aromatic l-amino acid decarboxylase (AADC) is a homodimeric pyridoxal phosphate-dependent enzyme responsible for the syntheses of dopamine and serotonin. Dopamine 130-138 dopa decarboxylase Homo sapiens 0-35 24054149-1 2013 Aromatic l-amino acid decarboxylase (AADC) is a homodimeric pyridoxal phosphate-dependent enzyme responsible for the syntheses of dopamine and serotonin. Dopamine 130-138 dopa decarboxylase Homo sapiens 37-41 23261515-2 2013 Dopamine is produced first by hydroxylalation of l-tyrosine to l-dihydroxyphenylalanine (l-dopa) and subsequently by the decarboxylation of l-dopa to dopamine catalysed by the enzymes tyrosine hydroxylase and aromatic l-amino acid decarboxylase (AADC) respectively. Dopamine 150-158 dopa decarboxylase Homo sapiens 209-244 23261515-2 2013 Dopamine is produced first by hydroxylalation of l-tyrosine to l-dihydroxyphenylalanine (l-dopa) and subsequently by the decarboxylation of l-dopa to dopamine catalysed by the enzymes tyrosine hydroxylase and aromatic l-amino acid decarboxylase (AADC) respectively. Dopamine 150-158 dopa decarboxylase Homo sapiens 246-250 23328075-1 2013 3,4-Dihydroxy-L-phenylalanine decarboxylase (DDC) is an enzyme implicated in the biosynthetic pathways of the neurotransmitters dopamine and probably serotonin. Dopamine 128-136 dopa decarboxylase Homo sapiens 45-48 23994933-2 2013 The aim of the study was to verify whether a combination of levodopa with DOPA decarboxylase and catechol-O-methyltransferase inhibitors (stalevo) could delay the development of dyskinesia compared to the standard two-component drug due to the more stable concentration levodopa in the blood that provided the persistent stimulation of dopamine receptors in the striatum. Dopamine 336-344 dopa decarboxylase Homo sapiens 74-92 22937181-1 2012 l-DOPA decarboxylase (DDC) plays an essential role in the enzymatic synthesis of dopamine and alterations in its gene expression have been reported in several malignancies. Dopamine 81-89 dopa decarboxylase Homo sapiens 0-20 23083099-2 2012 The DDC gene encodes L-DOPA decarboxylase, an enzyme catalyzing the decarboxylation of L-DOPA to dopamine. Dopamine 97-105 dopa decarboxylase Homo sapiens 4-7 22937181-1 2012 l-DOPA decarboxylase (DDC) plays an essential role in the enzymatic synthesis of dopamine and alterations in its gene expression have been reported in several malignancies. Dopamine 81-89 dopa decarboxylase Homo sapiens 22-25 22593174-1 2012 Aromatic L-amino acid decarboxylase (AADC) is required for the synthesis of the neurotransmitters dopamine and serotonin. Dopamine 98-106 dopa decarboxylase Homo sapiens 0-35 22593174-1 2012 Aromatic L-amino acid decarboxylase (AADC) is required for the synthesis of the neurotransmitters dopamine and serotonin. Dopamine 98-106 dopa decarboxylase Homo sapiens 37-41 22061622-4 2012 This hypothesis was tested by incubating recombinant human AADC, which actively catalyzes dopamine production from DOPA, with several TH. Dopamine 90-98 dopa decarboxylase Homo sapiens 59-63 22572099-6 2012 We provide new data about changes of expression profile of the dopamine-synthesizing enzyme DDC, the dopamine-degrading enzymes MAOA and MAOB and the D1-like family dopamine receptors in vitiligo skin and blood sera. Dopamine 63-71 dopa decarboxylase Homo sapiens 92-95 22017504-1 2012 Degeneration of nigrostriatal neurons in Parkinson"s disease (PD) causes progressive loss of aromatic l-amino acid decarboxylase (AADC), the enzyme that converts levodopa (l-DOPA) into dopamine in the striatum. Dopamine 185-193 dopa decarboxylase Homo sapiens 93-128 22017504-1 2012 Degeneration of nigrostriatal neurons in Parkinson"s disease (PD) causes progressive loss of aromatic l-amino acid decarboxylase (AADC), the enzyme that converts levodopa (l-DOPA) into dopamine in the striatum. Dopamine 185-193 dopa decarboxylase Homo sapiens 130-134 22572099-3 2012 METHODS: With the use of quantitative real-time polymerase chain reaction and ELISA the expression of genes connected to the dopamine pathway (PAH, PCD, TH, DDC, DBH, PNMT, GPX1, MAOA, MAOB, COMT, DRD1-DRD5, VMAT1 and VMAT2) was observed in vitiligo patients" and control subjects" skin and blood. Dopamine 125-133 dopa decarboxylase Homo sapiens 157-160 23646099-1 2012 BACKGROUND: Peripheral carbidopa (CD) levels directly impact on central dopamine (DA) production in Parkinson disease (PD) through extracerebral inhibition of dopa decarboxylase (AADC) resulting in an increase in levodopa (LD) bioavailability. Dopamine 72-80 dopa decarboxylase Homo sapiens 179-183 23646099-1 2012 BACKGROUND: Peripheral carbidopa (CD) levels directly impact on central dopamine (DA) production in Parkinson disease (PD) through extracerebral inhibition of dopa decarboxylase (AADC) resulting in an increase in levodopa (LD) bioavailability. Dopamine 82-84 dopa decarboxylase Homo sapiens 159-177 23430870-1 2012 BACKGROUND: Aromatic amino acid decarboxylase (AADC) deficiency is a rare autosomal recessive disorder resulting in a combined dopamine and serotonin deficiency. Dopamine 127-135 dopa decarboxylase Homo sapiens 47-51 23430895-5 2012 In this study, the hypothesis that in AADC deficiency relatively high-residual renal AADC-activity combined with high substrate availability of L-dopa leads to normal or elevated levels of urinary dopamine is tested and verified using 24-h urine collection of two AADC-deficient patients.Renal dopamine is a major regulator of natriuresis and plays a crucial role in the maintenance of sodium homeostasis. Dopamine 294-302 dopa decarboxylase Homo sapiens 38-42 23430895-5 2012 In this study, the hypothesis that in AADC deficiency relatively high-residual renal AADC-activity combined with high substrate availability of L-dopa leads to normal or elevated levels of urinary dopamine is tested and verified using 24-h urine collection of two AADC-deficient patients.Renal dopamine is a major regulator of natriuresis and plays a crucial role in the maintenance of sodium homeostasis. Dopamine 197-205 dopa decarboxylase Homo sapiens 38-42 23430895-1 2012 Aromatic L-amino acid decarboxylase (AADC) decarboxylates 3,4-L-dihydroxylphenylalanine (L-dopa) to dopamine, and 5-hydroxytryptophan to serotonin. Dopamine 100-108 dopa decarboxylase Homo sapiens 0-35 22088923-7 2012 PLP is also a required cofactor for dopamine synthesis by L-aromatic decarboxylase (L-AADC). Dopamine 36-44 dopa decarboxylase Homo sapiens 86-90 23430895-1 2012 Aromatic L-amino acid decarboxylase (AADC) decarboxylates 3,4-L-dihydroxylphenylalanine (L-dopa) to dopamine, and 5-hydroxytryptophan to serotonin. Dopamine 100-108 dopa decarboxylase Homo sapiens 37-41 23430895-3 2012 However, despite dopamine deficiency in the central nervous system, urinary dopamine excretion in AADC-deficient patients is normal to high.In human, renal AADC-activity is very high compared to other tissues including brain tissue. Dopamine 76-84 dopa decarboxylase Homo sapiens 98-102 22143761-1 2011 DOPA decarboxylase, the dimeric enzyme responsible for the synthesis of neurotransmitters dopamine and serotonin, is involved in severe neurological diseases such as Parkinson disease, schizophrenia, and depression. Dopamine 90-98 dopa decarboxylase Homo sapiens 0-18 23264832-1 2012 Dopa decarboxylase (DDC) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that by catalyzing the decarboxylation of L-Dopa and L-5-hydroxytryptophan produces the neurotransmitters dopamine and serotonin. Dopamine 182-190 dopa decarboxylase Homo sapiens 0-18 23264832-5 2012 On the other hand, AADC deficiency is a rare debilitating recessive genetic disorder due to mutations in AADC gene leading to the inability to synthesize dopamine and serotonin. Dopamine 154-162 dopa decarboxylase Homo sapiens 19-23 22384042-1 2012 Dopa decarboxylase (DDC), a pyridoxal 5"-phosphate (PLP) enzyme responsible for the biosynthesis of dopamine and serotonin, is involved in Parkinson"s disease (PD). Dopamine 100-108 dopa decarboxylase Homo sapiens 0-18 22384042-1 2012 Dopa decarboxylase (DDC), a pyridoxal 5"-phosphate (PLP) enzyme responsible for the biosynthesis of dopamine and serotonin, is involved in Parkinson"s disease (PD). Dopamine 100-108 dopa decarboxylase Homo sapiens 20-23 19800137-6 2009 The expression of enzymatically active DDC shows the endogenous production of dopamine in U937 cells and raises new questions about the enzyme"s involvement in immune responses. Dopamine 78-86 dopa decarboxylase Homo sapiens 39-42 20856911-3 2010 Levodopa is routinely combined with a dopa-decarboxylase inhibitor (DDCI) to prevent the conversion of levodopa into dopamine in peripheral circulation. Dopamine 117-125 dopa decarboxylase Homo sapiens 38-56 20424616-1 2010 BACKGROUND: L-DOPA decarboxylase (DDC) is an enzyme that catalyses, mainly, the decarboxylation of L-DOPA to dopamine and was found to be involved in many malignancies. Dopamine 109-117 dopa decarboxylase Homo sapiens 12-32 20424616-1 2010 BACKGROUND: L-DOPA decarboxylase (DDC) is an enzyme that catalyses, mainly, the decarboxylation of L-DOPA to dopamine and was found to be involved in many malignancies. Dopamine 109-117 dopa decarboxylase Homo sapiens 34-37 19941962-1 2010 PET studies with the DOPA decarboxylase substrate 6-[(18)F]fluoro-l-DOPA (FDOPA) reveal the storage of [(18)F]-fluorodopamine within synaptic vesicles, mainly of dopamine fibres. Dopamine 117-125 dopa decarboxylase Homo sapiens 21-39 20832343-0 2010 Urinary dopamine in aromatic L-amino acid decarboxylase deficiency: the unsolved paradox. Dopamine 8-16 dopa decarboxylase Homo sapiens 29-55 20832343-1 2010 INTRODUCTION: In aromatic L-amino acid decarboxylase (AADC) deficiency, a neurotransmitter biosynthesis defect, paradoxical normal or increased levels of urinary dopamine have been reported. Dopamine 162-170 dopa decarboxylase Homo sapiens 26-52 20832343-1 2010 INTRODUCTION: In aromatic L-amino acid decarboxylase (AADC) deficiency, a neurotransmitter biosynthesis defect, paradoxical normal or increased levels of urinary dopamine have been reported. Dopamine 162-170 dopa decarboxylase Homo sapiens 54-58 19857468-1 2010 Aromatic l-amino acid decarboxylase (AADC) enzymatic activity is essential for the biosynthesis of the serotonin and dopamine neurotransmitters, and AADC activity is functionally associated with a number of human neuronal disorders. Dopamine 117-125 dopa decarboxylase Homo sapiens 0-35 19857468-1 2010 Aromatic l-amino acid decarboxylase (AADC) enzymatic activity is essential for the biosynthesis of the serotonin and dopamine neurotransmitters, and AADC activity is functionally associated with a number of human neuronal disorders. Dopamine 117-125 dopa decarboxylase Homo sapiens 37-41 19358813-3 2009 Most monoenzymatic neurons possess one of the enzymes for dopamine (DA) synthesis, tyrosine hydroxylase (TH) or aromatic L-amino acid decarboxylase (AADC). Dopamine 58-66 dopa decarboxylase Homo sapiens 149-153 19580779-1 2009 The pyridoxal 5"-phosphate dependent-enzyme Dopa decarboxylase, responsible for the irreversible conversion of l-Dopa to dopamine, is an attractive drug target. Dopamine 121-129 dopa decarboxylase Homo sapiens 44-62 19041269-1 2009 L-DOPA decarboxylase (DDC) is a pyridoxal 5-phosphate (PLP)-dependent enzyme that catalyses the decarboxylation of L-DOPA to dopamine. Dopamine 125-133 dopa decarboxylase Homo sapiens 0-20 19041269-1 2009 L-DOPA decarboxylase (DDC) is a pyridoxal 5-phosphate (PLP)-dependent enzyme that catalyses the decarboxylation of L-DOPA to dopamine. Dopamine 125-133 dopa decarboxylase Homo sapiens 22-25 19828868-1 2009 BACKGROUND: In Parkinson disease (PD), the benefit of levodopa therapy becomes less marked over time, perhaps because degeneration of nigrostrial neurons causes progressive loss of aromatic l-amino acid decarboxylase (AADC), the enzyme that converts levodopa into dopamine. Dopamine 264-272 dopa decarboxylase Homo sapiens 181-216 19828868-1 2009 BACKGROUND: In Parkinson disease (PD), the benefit of levodopa therapy becomes less marked over time, perhaps because degeneration of nigrostrial neurons causes progressive loss of aromatic l-amino acid decarboxylase (AADC), the enzyme that converts levodopa into dopamine. Dopamine 264-272 dopa decarboxylase Homo sapiens 218-222 19396395-8 2009 The expression of the following three enzymes, TH, GTP cyclohydrolase I, which synthesizes the tetrahydrobiopterin cofactor of TH, and aromatic-L: -amino acid decarboxylase, which produces DA from L: -dopa, were induced in the monkey striatum using harmless adeno-associated virus vectors, resulting in a remarkable improvement in the symptoms affecting PD model monkeys Muramatsu (Hum Gene Ther 13:345-354, 2002). Dopamine 189-191 dopa decarboxylase Homo sapiens 135-172 19589043-5 2009 A dopa decarboxylase inhibitor (DDCI), such as carbidopa or benserazide, is administered with levodopa to attenuate its peripheral conversion to dopamine, reduce nausea and increase central bioavailability. Dopamine 145-153 dopa decarboxylase Homo sapiens 2-20 19172410-1 2009 BACKGROUND: Aromatic L-amino acid decarboxylase (AADC) deficiency is a disorder of biogenic amine metabolism resulting in generalized combined deficiency of serotonin, dopamine and catecholamines. Dopamine 168-176 dopa decarboxylase Homo sapiens 12-47 19172410-1 2009 BACKGROUND: Aromatic L-amino acid decarboxylase (AADC) deficiency is a disorder of biogenic amine metabolism resulting in generalized combined deficiency of serotonin, dopamine and catecholamines. Dopamine 168-176 dopa decarboxylase Homo sapiens 49-53 19231266-1 2009 The final step in production of the neurotransmitters dopamine and serotonin is catalyzed by aromatic l-amino acid decarboxylase (AADC). Dopamine 54-62 dopa decarboxylase Homo sapiens 130-134 19282221-4 2009 Dopamine-related neuronal structures in schizophrenic cases were investigated by using immunohistochemistry for tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC) and phenylethanolamine-N-methyltransferase (PNMT). Dopamine 0-8 dopa decarboxylase Homo sapiens 139-174 19282221-4 2009 Dopamine-related neuronal structures in schizophrenic cases were investigated by using immunohistochemistry for tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC) and phenylethanolamine-N-methyltransferase (PNMT). Dopamine 0-8 dopa decarboxylase Homo sapiens 176-180 19358813-4 2009 TH and AADC are enzymatically active in a substantial number of monoenzymatic neurons, where they are capable of converting L-tyrosine to L-3,4-dihydroxy-phenylalanine (L-DOPA) and L-DOPA to dopamine (DA) (or 5-hydroxy-tryptophan, 5-HTP to serotonin), respectively. Dopamine 191-199 dopa decarboxylase Homo sapiens 7-11 19358813-4 2009 TH and AADC are enzymatically active in a substantial number of monoenzymatic neurons, where they are capable of converting L-tyrosine to L-3,4-dihydroxy-phenylalanine (L-DOPA) and L-DOPA to dopamine (DA) (or 5-hydroxy-tryptophan, 5-HTP to serotonin), respectively. Dopamine 201-203 dopa decarboxylase Homo sapiens 7-11 19358813-5 2009 According to our data L-DOPA synthesized in monoenzymatic TH-neurons is released and taken up by monoenzymatic AADC-neurons for DA synthesis. Dopamine 128-130 dopa decarboxylase Homo sapiens 111-115 19109513-2 2008 The positron emission tomography (PET) radiotracer 6-[(18)F]fluoro-l-m-tyrosine (FMT) is a substrate of the dopamine-synthesizing enzyme, aromatic amino acid decarboxylase (AADC). Dopamine 108-116 dopa decarboxylase Homo sapiens 173-177 19131039-3 2009 DA in the striatum may be produced from exogenously administered l-dopa by various AADC-containing cells, such as serotonin neurons. Dopamine 0-2 dopa decarboxylase Homo sapiens 83-87 18401019-10 2008 These initial findings demonstrate the safety of the therapy; higher doses of adeno-associated viral vector containing the human aromatic l-amino acid decarboxylase gene in the next cohort of patients may further increase dopamine production in the putamen and provide more profound clinical benefit. Dopamine 222-230 dopa decarboxylase Homo sapiens 129-164 19198095-6 2008 In Japan, gene delivery of the dopamine synthesizing enzyme aromatic amino acid decarboxylase (AADC) to the striatum of PD patients is going on in Jichi Medical University. Dopamine 31-39 dopa decarboxylase Homo sapiens 95-99 19040557-6 2008 Enhancement of AAAD activity is functional, as the formation of dopamine from exogenous L-DOPA mirrors activity. Dopamine 64-72 dopa decarboxylase Homo sapiens 15-19 19040557-8 2008 We review the evidence for parallel modulation of AAAD activity and L-DOPA decarboxylation and propose that this knowledge can be exploited to optimize the formation of dopamine from exogenous L-DOPA. Dopamine 169-177 dopa decarboxylase Homo sapiens 50-54 18064905-1 2007 Dopamine(DA), the most widely distributed in the nervous system and functionally important chemical signal, is synthesized in DA-ergic neurons from L-tyrosine by means of two enzymes, tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC). Dopamine 0-8 dopa decarboxylase Homo sapiens 251-255 18035353-1 2008 PD gene therapy clinical trials have primarily focused on increasing the production of dopamine (DA) through supplemental amino acid decarboxylase (AADC) expression, neurotrophic support for surviving dopaminergic neurons (DAN) or altering brain circuitry to compensate for DA neuron loss. Dopamine 87-95 dopa decarboxylase Homo sapiens 148-152 18035353-1 2008 PD gene therapy clinical trials have primarily focused on increasing the production of dopamine (DA) through supplemental amino acid decarboxylase (AADC) expression, neurotrophic support for surviving dopaminergic neurons (DAN) or altering brain circuitry to compensate for DA neuron loss. Dopamine 97-99 dopa decarboxylase Homo sapiens 148-152 18064905-1 2007 Dopamine(DA), the most widely distributed in the nervous system and functionally important chemical signal, is synthesized in DA-ergic neurons from L-tyrosine by means of two enzymes, tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC). Dopamine 0-8 dopa decarboxylase Homo sapiens 214-249 17692830-3 2007 Weak to moderate dopamine immunoreactivity was observed in non-aminergic cells (possibly so-called "D" cells containing aromatic L-amino acid decarboxylase (AADC)) in several hypothalamic, midbrain, pontine and medullary nuclei. Dopamine 17-25 dopa decarboxylase Homo sapiens 129-155 17692830-3 2007 Weak to moderate dopamine immunoreactivity was observed in non-aminergic cells (possibly so-called "D" cells containing aromatic L-amino acid decarboxylase (AADC)) in several hypothalamic, midbrain, pontine and medullary nuclei. Dopamine 17-25 dopa decarboxylase Homo sapiens 157-161 17692830-4 2007 Intense dopamine immunoreactivity became visible in a large number of cells and axons (possibly containing AADC) with wide distribution in the brain following administration of L-DOPA with Pargyline. Dopamine 8-16 dopa decarboxylase Homo sapiens 107-111 17692830-5 2007 AADC is most likely active in cells and axons that take up L-DOPA, where it decarboxylates the L-DOPA to dopamine. Dopamine 105-113 dopa decarboxylase Homo sapiens 0-4 17447529-4 2007 One trial involves gene transfer of aromatic L-amino acid decarboxylase (AADC), an enzyme that converts L-dopa to dopamine, to restore therapeutic windows of orally administered L-dopa in advanced idiopathic PD. Dopamine 114-122 dopa decarboxylase Homo sapiens 36-71 18040154-6 2007 As for the initial step of clinical application, AAV vector-mediated AADC (aromatic L-amino acid decarboxylase; the enzyme converting L-DOPA to DA) gene transfer in combination with oral administration of L-DOPA would be appropriate, since DA production can be regulated by adjusting the dose of L-DOPA. Dopamine 144-146 dopa decarboxylase Homo sapiens 69-73 18040154-6 2007 As for the initial step of clinical application, AAV vector-mediated AADC (aromatic L-amino acid decarboxylase; the enzyme converting L-DOPA to DA) gene transfer in combination with oral administration of L-DOPA would be appropriate, since DA production can be regulated by adjusting the dose of L-DOPA. Dopamine 144-146 dopa decarboxylase Homo sapiens 75-110 18040154-6 2007 As for the initial step of clinical application, AAV vector-mediated AADC (aromatic L-amino acid decarboxylase; the enzyme converting L-DOPA to DA) gene transfer in combination with oral administration of L-DOPA would be appropriate, since DA production can be regulated by adjusting the dose of L-DOPA. Dopamine 240-242 dopa decarboxylase Homo sapiens 69-73 18040154-6 2007 As for the initial step of clinical application, AAV vector-mediated AADC (aromatic L-amino acid decarboxylase; the enzyme converting L-DOPA to DA) gene transfer in combination with oral administration of L-DOPA would be appropriate, since DA production can be regulated by adjusting the dose of L-DOPA. Dopamine 240-242 dopa decarboxylase Homo sapiens 75-110 17447529-4 2007 One trial involves gene transfer of aromatic L-amino acid decarboxylase (AADC), an enzyme that converts L-dopa to dopamine, to restore therapeutic windows of orally administered L-dopa in advanced idiopathic PD. Dopamine 114-122 dopa decarboxylase Homo sapiens 73-77 20641732-15 2004 Like endogenous l-DOPA, [(18)F]FDOPA is converted by the enzyme aromatic l-amino acid decarboxylase (AAAD) to the dopamine analog fluorodopamine. Dopamine 114-122 dopa decarboxylase Homo sapiens 64-99 17578016-5 2007 AADC is enzymatically active in all studied monoenzymatic neurons converting extracellular L-dihydroxyphenylalanine (L-DOPA) or 5-hydroxytryptophan captured from the extracellular space, to DA or serotonin, respectively. Dopamine 190-192 dopa decarboxylase Homo sapiens 0-4 17430130-8 2007 The DA delivery strategy, on the other hand, aims at triple transduction of the TH, GCH1 and aromatic amino-acid decarboxylase (AADC) enzymes, and thereby provide a higher rate of conversion of DOPA to DA. Dopamine 4-6 dopa decarboxylase Homo sapiens 128-132 17430130-8 2007 The DA delivery strategy, on the other hand, aims at triple transduction of the TH, GCH1 and aromatic amino-acid decarboxylase (AADC) enzymes, and thereby provide a higher rate of conversion of DOPA to DA. Dopamine 202-204 dopa decarboxylase Homo sapiens 128-132 16580727-3 2007 This was confirmed by the decreased DA content in the presence of benserazide, an AADC inhibitor. Dopamine 36-38 dopa decarboxylase Homo sapiens 82-86 18427455-2 2007 These complications may be reduced due to the constant (physiologic) stimulation of post-synaptic dopamine receptors that, to a certain degree, provides the drug stalevo, which contains levodopa and 2 enzyme inhibitors, dopa decarboxylase (carbidopa) and catechol-O-methyltransferase (entacapone). Dopamine 98-106 dopa decarboxylase Homo sapiens 220-238 15879433-1 2005 DOPA decarboxylase (DDC; also known as L-amino acid decarboxylase; AADC) is involved in the synthesis of dopamine, norepinephrine and serotonin. Dopamine 105-113 dopa decarboxylase Homo sapiens 0-18 16829205-1 2006 Dopamine, the major neurotransmitter depleted in Parkinson disease, can be synthesized and regulated in vivo with a combination of intrastriatal AAV-hAADC gene therapy and administration of the dopamine precursor l-Dopa. Dopamine 0-8 dopa decarboxylase Homo sapiens 149-154 16829205-4 2006 AAV-hAADC restores the ability of the striatum to convert l-Dopa into dopamine efficiently. Dopamine 70-78 dopa decarboxylase Homo sapiens 4-9 16126007-3 2006 Expression of hAADC, the enzyme that converts L-dopa to dopamine, was dependent on reconstitution of a functional transcription factor (TF) by the dimerizer rapamycin. Dopamine 56-64 dopa decarboxylase Homo sapiens 14-19 16447758-6 2005 A clinical trial to evaluate the safety and efficacy of AAV vector-mediated gene transfer of aromatic L-amino acid decarboxylase, an enzyme that converts L-dopa to dopamine, is underway. Dopamine 164-172 dopa decarboxylase Homo sapiens 93-128 16332212-2 2006 The enzyme (DDC) catalyzes the production of the neural transmitters dopamine and serotonin. Dopamine 69-77 dopa decarboxylase Homo sapiens 12-15 17135716-11 2006 The apparent limited expression of AADC indicates that dopamine might be produced in human neurosecretory neurons under activation of the hypothalamoneurohypophyseal system, although the possibility that L-dopa is the final product cannot be excluded. Dopamine 55-63 dopa decarboxylase Homo sapiens 35-39 15879433-1 2005 DOPA decarboxylase (DDC; also known as L-amino acid decarboxylase; AADC) is involved in the synthesis of dopamine, norepinephrine and serotonin. Dopamine 105-113 dopa decarboxylase Homo sapiens 20-23 15879433-1 2005 DOPA decarboxylase (DDC; also known as L-amino acid decarboxylase; AADC) is involved in the synthesis of dopamine, norepinephrine and serotonin. Dopamine 105-113 dopa decarboxylase Homo sapiens 67-71 15900211-7 2005 These results demonstrate that the A1 allele of DRD2 gene is associated with increased striatal activity of aromatic L-amino acid decarboxylase, the final enzyme in the biosynthesis of dopamine and the rate-limiting enzyme for trace amine (e.g. beta-phenylethylamine) synthesis. Dopamine 185-193 dopa decarboxylase Homo sapiens 108-143 15500713-8 2004 When Cos7 cells expressing TH, AADC and GCH-I were cocultured, they produced large amount of dopamine in the condition of existance of L-tyrosine. Dopamine 93-101 dopa decarboxylase Homo sapiens 31-35 15836622-10 2005 The protective effects were due primarily to AADC-dependent conversion of L-DOPA to dopamine and an increase in induction of vesicular monoamine transporter resulting in dopamine storage in cultured cells. Dopamine 84-92 dopa decarboxylase Homo sapiens 45-49 15821966-0 2005 Visualisation of impaired dopamine biosynthesis in a case of aromatic L-amino acid decarboxylase deficiency by co-registered 18F-FDOPA PET and magnetic resonance imaging. Dopamine 26-34 dopa decarboxylase Homo sapiens 61-96 15152479-6 2003 As for the initial step of clinical application, AADC (aromatic L-amino acid decarboxylase; the enzyme converting L-DOPA to DA) gene transfer in combination with oral administration of L-DOPA would be appropriate, since DA production can be regulated by the dose of L-DOPA. Dopamine 124-126 dopa decarboxylase Homo sapiens 49-53 14760382-2 2004 One of the upregulated genes is dopa decarboxylase (DDC), which is responsible for the synthesis of the key neurotransmitters dopamine and serotonine. Dopamine 126-134 dopa decarboxylase Homo sapiens 32-50 14760382-2 2004 One of the upregulated genes is dopa decarboxylase (DDC), which is responsible for the synthesis of the key neurotransmitters dopamine and serotonine. Dopamine 126-134 dopa decarboxylase Homo sapiens 52-55 15318031-2 2004 DOPA decarboxylase (DDC) is an enzyme involved directly in the synthesis of dopamine and serotonin, and indirectly in the synthesis of noradrenaline. Dopamine 76-84 dopa decarboxylase Homo sapiens 0-18 15318031-2 2004 DOPA decarboxylase (DDC) is an enzyme involved directly in the synthesis of dopamine and serotonin, and indirectly in the synthesis of noradrenaline. Dopamine 76-84 dopa decarboxylase Homo sapiens 20-23 15191803-12 2004 These cells were also found to express aromatic-l-amino acid decarboxylase (AADC) and vesicular monoamine transporter-2 (VMAT), both of which are important molecules for the synthesis and the storage of DA, respectively. Dopamine 203-205 dopa decarboxylase Homo sapiens 39-74 15191803-12 2004 These cells were also found to express aromatic-l-amino acid decarboxylase (AADC) and vesicular monoamine transporter-2 (VMAT), both of which are important molecules for the synthesis and the storage of DA, respectively. Dopamine 203-205 dopa decarboxylase Homo sapiens 76-80 15152479-6 2003 As for the initial step of clinical application, AADC (aromatic L-amino acid decarboxylase; the enzyme converting L-DOPA to DA) gene transfer in combination with oral administration of L-DOPA would be appropriate, since DA production can be regulated by the dose of L-DOPA. Dopamine 124-126 dopa decarboxylase Homo sapiens 55-90 15152479-6 2003 As for the initial step of clinical application, AADC (aromatic L-amino acid decarboxylase; the enzyme converting L-DOPA to DA) gene transfer in combination with oral administration of L-DOPA would be appropriate, since DA production can be regulated by the dose of L-DOPA. Dopamine 220-222 dopa decarboxylase Homo sapiens 49-53 15152479-6 2003 As for the initial step of clinical application, AADC (aromatic L-amino acid decarboxylase; the enzyme converting L-DOPA to DA) gene transfer in combination with oral administration of L-DOPA would be appropriate, since DA production can be regulated by the dose of L-DOPA. Dopamine 220-222 dopa decarboxylase Homo sapiens 55-90 10945765-6 2000 In vitro experiments showed that triple transduction with AAV-TH, AAV-AADC, and AAV-GCH resulted in greater dopamine production than double transduction with AAV-TH and AAV-AADC in 293 cells. Dopamine 108-116 dopa decarboxylase Homo sapiens 70-74 12938190-8 2003 We explore here the hypothesis that gene transfer of aromatic acid decarboxylase (AADC), a key enzyme in the pathway, will make neuronal cells more efficiently convert L-dopa into dopamine. Dopamine 180-188 dopa decarboxylase Homo sapiens 82-86 12938190-13 2003 Gene transfer of AADC gene in neuronal cells imparted the ability on the transduced cells to efficiently convert L-dopa into dopamine. Dopamine 125-133 dopa decarboxylase Homo sapiens 17-21 12718431-1 2003 L-Dopa decarboxylase (DDC) is a pyridoxal 5-phosphate (PLP)-dependent enzyme that catalyses the decarboxylation of L-Dopa to dopamine. Dopamine 125-133 dopa decarboxylase Homo sapiens 0-20 12718431-1 2003 L-Dopa decarboxylase (DDC) is a pyridoxal 5-phosphate (PLP)-dependent enzyme that catalyses the decarboxylation of L-Dopa to dopamine. Dopamine 125-133 dopa decarboxylase Homo sapiens 22-25 12555230-1 2003 Dopa decarboxylase (DDC) catalyses the synthesis of both dopamine and serotonin as well as trace amines suggested to possess neuromodulating capabilities. Dopamine 57-65 dopa decarboxylase Homo sapiens 0-18 12200739-1 2002 Aromatic L-amino acid decarboxylase (AADC) is a vitamin B 6 requiring enzyme involved in the biosynthesis of the neurotransmitters dopamine (DA) and serotonin. Dopamine 131-139 dopa decarboxylase Homo sapiens 0-35 12200739-1 2002 Aromatic L-amino acid decarboxylase (AADC) is a vitamin B 6 requiring enzyme involved in the biosynthesis of the neurotransmitters dopamine (DA) and serotonin. Dopamine 131-139 dopa decarboxylase Homo sapiens 37-41 12200739-1 2002 Aromatic L-amino acid decarboxylase (AADC) is a vitamin B 6 requiring enzyme involved in the biosynthesis of the neurotransmitters dopamine (DA) and serotonin. Dopamine 141-143 dopa decarboxylase Homo sapiens 0-35 12200739-1 2002 Aromatic L-amino acid decarboxylase (AADC) is a vitamin B 6 requiring enzyme involved in the biosynthesis of the neurotransmitters dopamine (DA) and serotonin. Dopamine 141-143 dopa decarboxylase Homo sapiens 37-41 12084631-1 2002 Historically, 3,4-dihydroxyphenylalanine (DOPA) has been considered to be an inert amino acid that alleviates the symptoms of Parkinson"s disease by its conversion to dopamine via the enzyme aromatic L-amino acid decarboxylase. Dopamine 167-175 dopa decarboxylase Homo sapiens 191-226 11860702-2 2002 In addition to tyrosine hydroxylase (TH) and aromatic-L-amino-acid decarboxylase (AADC), GTP cyclohydrolase I (GCH) is necessary for efficient DA production. Dopamine 143-145 dopa decarboxylase Homo sapiens 82-86 11860702-9 2002 Microdialysis demonstrated that concentrations of DA in the AAV-TH/-AADC/-GCH-injected putamen were increased compared with the control side. Dopamine 50-52 dopa decarboxylase Homo sapiens 68-72 11889758-2 2002 A Combination therapy of a dopamine receptor agonist and levodopa/DCI(DOPA-decarboxylase inhibitor) is commonly used to control the complication. Dopamine 27-35 dopa decarboxylase Homo sapiens 70-88 12235825-3 2001 Three enzymes are necessary for efficient dopamine synthesis: tyrosine hydroxylase (TH) converts tyrosine to L-DOPA, aromatic L-amino acid decarboxylase (AADC) then converts L-DOPA to dopamine, and guanosine triphosphate cyclohydrolase I (GCH) is the rate-limiting enzyme for the synthesis of TH co-factor tetrahydrobiopterine. Dopamine 42-50 dopa decarboxylase Homo sapiens 154-158 12235825-3 2001 Three enzymes are necessary for efficient dopamine synthesis: tyrosine hydroxylase (TH) converts tyrosine to L-DOPA, aromatic L-amino acid decarboxylase (AADC) then converts L-DOPA to dopamine, and guanosine triphosphate cyclohydrolase I (GCH) is the rate-limiting enzyme for the synthesis of TH co-factor tetrahydrobiopterine. Dopamine 184-192 dopa decarboxylase Homo sapiens 154-158 11685243-1 2001 DOPA decarboxylase (DDC) is responsible for the synthesis of the key neurotransmitters dopamine and serotonin via decarboxylation of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan, respectively. Dopamine 87-95 dopa decarboxylase Homo sapiens 0-18 11685243-1 2001 DOPA decarboxylase (DDC) is responsible for the synthesis of the key neurotransmitters dopamine and serotonin via decarboxylation of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan, respectively. Dopamine 87-95 dopa decarboxylase Homo sapiens 20-23 11592835-5 2001 In animals receiving AAV2-AADC, dopamine production was restored to 50% of normal levels 12 weeks after the infusion. Dopamine 32-40 dopa decarboxylase Homo sapiens 26-30 14566408-2 2003 Since the expression of tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) in the biosynthetic pathway for dopamine are low, a promising approach to the gene therapy of PD is to augment the gene expression of the enzymes in the biosynthetic pathway for dopamine. Dopamine 129-137 dopa decarboxylase Homo sapiens 54-89 14566408-2 2003 Since the expression of tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) in the biosynthetic pathway for dopamine are low, a promising approach to the gene therapy of PD is to augment the gene expression of the enzymes in the biosynthetic pathway for dopamine. Dopamine 129-137 dopa decarboxylase Homo sapiens 91-95 14566408-2 2003 Since the expression of tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) in the biosynthetic pathway for dopamine are low, a promising approach to the gene therapy of PD is to augment the gene expression of the enzymes in the biosynthetic pathway for dopamine. Dopamine 275-283 dopa decarboxylase Homo sapiens 91-95 12808505-2 2003 DEVELOPMENT: Gene therapy carried out to this illness includes the liberation of genes encoding biosynthetic enzymes for dopamine synthesis: tyrosine hydroxylase, AADC and GTP cyclohydrolase and neurotrophic factors like GDNF which promotes the survival and maintenance of dopamin rgic neurons. Dopamine 121-129 dopa decarboxylase Homo sapiens 163-167 12116187-2 2002 DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase, is an enzyme involved directly in the synthesis of dopamine and serotonin and indirectly in the synthesis of noradrenaline. Dopamine 128-136 dopa decarboxylase Homo sapiens 0-18 12116187-2 2002 DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase, is an enzyme involved directly in the synthesis of dopamine and serotonin and indirectly in the synthesis of noradrenaline. Dopamine 128-136 dopa decarboxylase Homo sapiens 20-23 12116187-2 2002 DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase, is an enzyme involved directly in the synthesis of dopamine and serotonin and indirectly in the synthesis of noradrenaline. Dopamine 128-136 dopa decarboxylase Homo sapiens 40-75 12200739-2 2002 Lack of AADC leads to a combined deficiency of the catecholamines DA, norepinephrine (NE), epinephrine (E) as well as of serotonin. Dopamine 66-68 dopa decarboxylase Homo sapiens 8-12 11532645-4 2001 Levodopa is converted to dopamine within the brain by dopa decarboxylase, replenishing central dopamine stores and potentially reversing the motor symptoms of PD. Dopamine 25-33 dopa decarboxylase Homo sapiens 54-72 11443526-1 2001 Dopa decarboxylase (DDC) is an enzyme which catalyses the decarboxylation of both dopa to dopamine and L-5 hydroxytryptophan to serotonin. Dopamine 90-98 dopa decarboxylase Homo sapiens 0-18 11443526-1 2001 Dopa decarboxylase (DDC) is an enzyme which catalyses the decarboxylation of both dopa to dopamine and L-5 hydroxytryptophan to serotonin. Dopamine 90-98 dopa decarboxylase Homo sapiens 20-23 11148450-2 2001 Aromatic L-amino acid decarboxylase (AADC) gene, the product of which catalyzes the synthesis of serotonin and dopamine from L-5-hydroxytryptophan and L-3,4-dihydroxyphenylalanine, respectively, was characterized. Dopamine 111-119 dopa decarboxylase Homo sapiens 37-41 10900396-15 2000 Our results suggest that co-administration of entacapone with L-dopa/DDC inhibitor, with or without selegiline, improves clinical disability, is safe, but may also enhance dopamine-related adverse events to some extent in PD patients with end-of-dose type motor fluctuations. Dopamine 172-180 dopa decarboxylase Homo sapiens 69-72 11144954-1 2000 L-3,4-Dihydroxyphenylalanine (L-dopa) is the mainstay of therapy for patients with Parkinson"s disease (PD), and mediates its primary effects through conversion into dopamine by aromatic L-amino acid decarboxylase (AADC). Dopamine 166-174 dopa decarboxylase Homo sapiens 187-213 11144954-1 2000 L-3,4-Dihydroxyphenylalanine (L-dopa) is the mainstay of therapy for patients with Parkinson"s disease (PD), and mediates its primary effects through conversion into dopamine by aromatic L-amino acid decarboxylase (AADC). Dopamine 166-174 dopa decarboxylase Homo sapiens 215-219 11144954-2 2000 Given the loss of AADC-containing nigrostriatal dopaminergic neurons in PD, however, the location of residual AADC that converts L-dopa into dopamine remains controversial. Dopamine 48-56 dopa decarboxylase Homo sapiens 18-22 10945765-3 2000 We previously showed that the coexpression of tyrosine hydroxylase (TH) and aromatic-L-amino-acid decarboxylase (AADC), using two separate adeno-associated virus (AAV) vectors, resulted in more effective dopamine production and more remarkable behavioral recovery in 6-hydroxydopamine-lesioned parkinsonian rats, compared with the expression of TH alone. Dopamine 204-212 dopa decarboxylase Homo sapiens 76-111 10945765-3 2000 We previously showed that the coexpression of tyrosine hydroxylase (TH) and aromatic-L-amino-acid decarboxylase (AADC), using two separate adeno-associated virus (AAV) vectors, resulted in more effective dopamine production and more remarkable behavioral recovery in 6-hydroxydopamine-lesioned parkinsonian rats, compared with the expression of TH alone. Dopamine 204-212 dopa decarboxylase Homo sapiens 113-117 10889538-1 2000 Aromatic L-amino acid decarboxylase (AADC) is a relatively non specific enzyme involved in the biosynthesis of several classical neurotransmitters including dopamine and 5-hydroxytryptamine (5HT; serotonin). Dopamine 157-165 dopa decarboxylase Homo sapiens 0-35 10877910-1 2000 Using an approach that combines gene therapy with aromatic l-amino acid decarboxylase (AADC) gene and a pro-drug (l-dopa), dopamine, the neurotransmitter involved in Parkinson"s disease, can be synthesized and regulated. Dopamine 123-131 dopa decarboxylase Homo sapiens 59-85 10877910-2 2000 Striatal neurons infected with the AADC gene by an adeno-associated viral vector can convert peripheral l-dopa to dopamine and may therefore provide a buffer for unmetabolized l-dopa. Dopamine 114-122 dopa decarboxylase Homo sapiens 35-39 10877910-4 2000 In addition, the imbalance in dopamine production between the nigrostriatal and mesolimbic dopaminergic systems can be corrected by using AADC gene delivery to the striatum. Dopamine 30-38 dopa decarboxylase Homo sapiens 138-142 10889538-1 2000 Aromatic L-amino acid decarboxylase (AADC) is a relatively non specific enzyme involved in the biosynthesis of several classical neurotransmitters including dopamine and 5-hydroxytryptamine (5HT; serotonin). Dopamine 157-165 dopa decarboxylase Homo sapiens 37-41 10450262-11 1999 Abnormality in dopa decarboxylase activity may be primary or secondary to deficits in other functional units of the dopamine pathway (e.g., receptor, uptake transporter, vesicular transporter, degradation enzymes). Dopamine 116-124 dopa decarboxylase Homo sapiens 15-33 10616810-4 2000 6-I-L-mTyr had a predilection for the cerebral aromatic L-amino acid decarboxylase (DOPA decarboxylase), the final enzyme of dopamine biosynthesis. Dopamine 125-133 dopa decarboxylase Homo sapiens 84-102 11128607-2 2000 A promising approach to the gene therapy of PD is intrastriatal expression of dopamine-synthesizing enzymes [tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC)]. Dopamine 78-86 dopa decarboxylase Homo sapiens 139-174 11128607-2 2000 A promising approach to the gene therapy of PD is intrastriatal expression of dopamine-synthesizing enzymes [tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC)]. Dopamine 78-86 dopa decarboxylase Homo sapiens 176-180 10578236-1 1999 DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase (AADC), is an enzyme involved in the synthesis of the important neurotransmitters dopamine, norepinephrine, and serotonin. Dopamine 158-166 dopa decarboxylase Homo sapiens 0-18 10578236-1 1999 DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase (AADC), is an enzyme involved in the synthesis of the important neurotransmitters dopamine, norepinephrine, and serotonin. Dopamine 158-166 dopa decarboxylase Homo sapiens 20-23 10578236-1 1999 DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase (AADC), is an enzyme involved in the synthesis of the important neurotransmitters dopamine, norepinephrine, and serotonin. Dopamine 158-166 dopa decarboxylase Homo sapiens 40-75 10578236-1 1999 DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase (AADC), is an enzyme involved in the synthesis of the important neurotransmitters dopamine, norepinephrine, and serotonin. Dopamine 158-166 dopa decarboxylase Homo sapiens 77-81 10522874-2 1999 BACKGROUND: AADC is a required enzyme in dopamine, norepinephrine, epinephrine, and serotonin biosynthesis. Dopamine 41-49 dopa decarboxylase Homo sapiens 12-16 9535130-0 1998 A dopamine-synthesizing cell group demonstrated in the human basal forebrain by dual labeling immunohistochemical technique of tyrosine hydroxylase and aromatic L-amino acid decarboxylase. Dopamine 2-10 dopa decarboxylase Homo sapiens 161-187 10821639-1 1999 Immunoreactivity for aromatic L-amino acid decarboxylase (AADC), the second step dopamine-synthesizing enzyme, was found immunohistochemically in neurons of the human anterior cingulate cortex (ACC). Dopamine 81-89 dopa decarboxylase Homo sapiens 21-56 10821639-1 1999 Immunoreactivity for aromatic L-amino acid decarboxylase (AADC), the second step dopamine-synthesizing enzyme, was found immunohistochemically in neurons of the human anterior cingulate cortex (ACC). Dopamine 81-89 dopa decarboxylase Homo sapiens 58-62 10821639-4 1999 AADC neurons in the human ACC might transform L-DOPA to dopamine, droxidopa to noradrenaline, and/or 5-hydroxytryptophan to serotonin. Dopamine 56-64 dopa decarboxylase Homo sapiens 0-4 10343328-9 1999 This increase of the AADC activity and the decrease of monoamine oxidase activity may contribute to the increase of extracellular DA during asphyxia which is expected to be involved in severe disturbances of neuronal metabolism, e.g., by generating free radicals. Dopamine 130-132 dopa decarboxylase Homo sapiens 21-25 9893421-8 1999 Based on the known regulation of DOPA decarboxylase activity by post- and presynaptic receptors, and by extracellular dopamine concentration, abnormal activity in this enzyme may reflect deficits in a variety of functional elements of the dopamine system. Dopamine 118-126 dopa decarboxylase Homo sapiens 33-51 9893421-8 1999 Based on the known regulation of DOPA decarboxylase activity by post- and presynaptic receptors, and by extracellular dopamine concentration, abnormal activity in this enzyme may reflect deficits in a variety of functional elements of the dopamine system. Dopamine 239-247 dopa decarboxylase Homo sapiens 33-51 9747462-1 1998 An adeno-associated virus (AAV) vector, expressing genes for human tyrosine hydroxylase (TH) and aromatic amino acid decarboxylase (AADC), demonstrated significantly increased production of dopamine in 293 (human embryonic kidney) cells. Dopamine 190-198 dopa decarboxylase Homo sapiens 132-136 9747462-5 1998 Several TH/aadc-treated monkeys showed elevated levels of dopamine near injection tracts after 2.5 months. Dopamine 58-66 dopa decarboxylase Homo sapiens 11-15 9572873-15 1998 271, 23954-23959], the conversion of dopamine (DA) into 3,4-dihydroxyphenylacetaldehyde and ammonia catalyzed by DDC is accompanied by irreversible loss of decarboxylase activity. Dopamine 37-45 dopa decarboxylase Homo sapiens 113-116 9572873-15 1998 271, 23954-23959], the conversion of dopamine (DA) into 3,4-dihydroxyphenylacetaldehyde and ammonia catalyzed by DDC is accompanied by irreversible loss of decarboxylase activity. Dopamine 47-49 dopa decarboxylase Homo sapiens 113-116 9613721-3 1998 The role of additional genes such as GTP cyclohydrolase 1 and aromatic L-amino acid decarboxylase in optimal delivery of dopamine in animal models is reviewed. Dopamine 121-129 dopa decarboxylase Homo sapiens 62-97 9084422-1 1997 To study the possibility that increasing striatal activity of aromatic L-amino acid decarboxylase (AADC; EC 4.1.1.28) can increase dopamine production in dopamine denervated striatum in response to L-3,4-dihydroxy-phenylalanine (L-DOPA) administration, we grafted Cos cells stably expressing the human AADC gene (Cos-haadc cells) into 6-hydroxydopamine denervated rat striatum. Dopamine 154-162 dopa decarboxylase Homo sapiens 99-103 9302099-1 1997 In the human striatum, we immunohistochemically demonstrated many neurons that were immunoreactive for aromatic L-amino acid decarboxylase (AADC; the second step dopamine-synthesizing enzyme) but not for tyrosine hydroxylase (TH; the first step dopamine-synthesizing enzyme). Dopamine 162-170 dopa decarboxylase Homo sapiens 103-138 9302099-1 1997 In the human striatum, we immunohistochemically demonstrated many neurons that were immunoreactive for aromatic L-amino acid decarboxylase (AADC; the second step dopamine-synthesizing enzyme) but not for tyrosine hydroxylase (TH; the first step dopamine-synthesizing enzyme). Dopamine 245-253 dopa decarboxylase Homo sapiens 103-138 9084422-1 1997 To study the possibility that increasing striatal activity of aromatic L-amino acid decarboxylase (AADC; EC 4.1.1.28) can increase dopamine production in dopamine denervated striatum in response to L-3,4-dihydroxy-phenylalanine (L-DOPA) administration, we grafted Cos cells stably expressing the human AADC gene (Cos-haadc cells) into 6-hydroxydopamine denervated rat striatum. Dopamine 131-139 dopa decarboxylase Homo sapiens 71-97 9084422-11 1997 These findings demonstrate that enhancing striatal AADC activity can improve dopamine bioformation in response to systemically administered L-DOPA. Dopamine 77-85 dopa decarboxylase Homo sapiens 51-55 9084422-1 1997 To study the possibility that increasing striatal activity of aromatic L-amino acid decarboxylase (AADC; EC 4.1.1.28) can increase dopamine production in dopamine denervated striatum in response to L-3,4-dihydroxy-phenylalanine (L-DOPA) administration, we grafted Cos cells stably expressing the human AADC gene (Cos-haadc cells) into 6-hydroxydopamine denervated rat striatum. Dopamine 131-139 dopa decarboxylase Homo sapiens 99-103 9084422-1 1997 To study the possibility that increasing striatal activity of aromatic L-amino acid decarboxylase (AADC; EC 4.1.1.28) can increase dopamine production in dopamine denervated striatum in response to L-3,4-dihydroxy-phenylalanine (L-DOPA) administration, we grafted Cos cells stably expressing the human AADC gene (Cos-haadc cells) into 6-hydroxydopamine denervated rat striatum. Dopamine 154-162 dopa decarboxylase Homo sapiens 71-97 9013415-6 1996 We conclude that brain areas with marked reductions in dopamine nerve terminals and DDC activity have a diminished capacity to synthesize dopamine and also lack storage mechanisms to protect the newly synthesized dopamine from degradative metabolism. Dopamine 138-146 dopa decarboxylase Homo sapiens 84-87 9013415-6 1996 We conclude that brain areas with marked reductions in dopamine nerve terminals and DDC activity have a diminished capacity to synthesize dopamine and also lack storage mechanisms to protect the newly synthesized dopamine from degradative metabolism. Dopamine 138-146 dopa decarboxylase Homo sapiens 84-87 8584678-5 1995 Indeed, the "on-off phenomenon" where there are fluctuations between off-periods of marked akinesia over several hours with on-periods of improved motility may be related to oscillating or poorly modulated AAAD activity and conversion of L-DOPA to DA. Dopamine 248-250 dopa decarboxylase Homo sapiens 206-210 7595534-1 1995 Aromatic L-amino acid decarboxylase (AADC) is expressed in a wide variety of tissues, including those where it is known to convert L-DOPA and 5-hydroxytryptophan to dopamine and serotonin, respectively. Dopamine 165-173 dopa decarboxylase Homo sapiens 0-35 7595534-1 1995 Aromatic L-amino acid decarboxylase (AADC) is expressed in a wide variety of tissues, including those where it is known to convert L-DOPA and 5-hydroxytryptophan to dopamine and serotonin, respectively. Dopamine 165-173 dopa decarboxylase Homo sapiens 37-41 7567987-5 1995 Aromatic L-amino acid decarboxylase catalyzes the decarboxylation of L-5-hydroxytryptophan to serotonin and that of L-3,4-dihydroxyphenylalanine to dopamine. Dopamine 148-156 dopa decarboxylase Homo sapiens 0-35 8584678-2 1995 In the striatum AAAD activity is increased by neuronal firing and diminished or enhanced by activation or blocking dopamine (DA) D1 or D2 receptors, respectively. Dopamine 115-123 dopa decarboxylase Homo sapiens 16-20 8584678-2 1995 In the striatum AAAD activity is increased by neuronal firing and diminished or enhanced by activation or blocking dopamine (DA) D1 or D2 receptors, respectively. Dopamine 125-127 dopa decarboxylase Homo sapiens 16-20 8237142-1 1993 Aromatic L-amino acid decarboxylase (AADC) decarboxylates both L-5-hydroxytryptophan to serotonin in serotonergic neurons and pineal cells, and L-dopa to dopamine in catecholaminergic neurons and adrenal medullary cells. Dopamine 154-162 dopa decarboxylase Homo sapiens 0-35 8584678-4 1995 In Parkinson"s disease AAAD is the rate-controlling enzyme for the synthesis of DA when L-DOPA is administered and any change of AAAD activity could have clinical consequences. Dopamine 80-82 dopa decarboxylase Homo sapiens 23-27 8584678-4 1995 In Parkinson"s disease AAAD is the rate-controlling enzyme for the synthesis of DA when L-DOPA is administered and any change of AAAD activity could have clinical consequences. Dopamine 80-82 dopa decarboxylase Homo sapiens 129-133 7812735-4 1994 In order to clarify this relationship, the DOPA decarboxylase inhibitor carbidopa was used to abolish dopamine synthesis during a meat meal. Dopamine 102-110 dopa decarboxylase Homo sapiens 43-61 8237142-1 1993 Aromatic L-amino acid decarboxylase (AADC) decarboxylates both L-5-hydroxytryptophan to serotonin in serotonergic neurons and pineal cells, and L-dopa to dopamine in catecholaminergic neurons and adrenal medullary cells. Dopamine 154-162 dopa decarboxylase Homo sapiens 37-41 8237142-5 1993 We expressed a recombinant human AADC in COS cells and proved that the expressed enzyme decarboxylated both L-5-hydroxytryptophan to serotonin and L-dopa to dopamine. Dopamine 157-165 dopa decarboxylase Homo sapiens 33-37 1540578-1 1992 Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines. Dopamine 139-147 dopa decarboxylase Homo sapiens 0-35 8458598-1 1993 L-Dopa is converted to dopamine by aromatic-L-amino acid decarboxylase (AADC). Dopamine 23-31 dopa decarboxylase Homo sapiens 35-70 8458598-1 1993 L-Dopa is converted to dopamine by aromatic-L-amino acid decarboxylase (AADC). Dopamine 23-31 dopa decarboxylase Homo sapiens 72-76 8417009-1 1993 DOPA decarboxylase is the enzyme directly responsible for the synthesis of the neurotransmitters dopamine and serotonin, and indirectly of noradrenaline, in brain. Dopamine 97-105 dopa decarboxylase Homo sapiens 0-18 1361977-4 1992 It appears that dopamine is synthesized by TH and AADC in dorsal motor vagal cells and is then rapidly transported from the perikarya. Dopamine 16-24 dopa decarboxylase Homo sapiens 50-54 1540578-1 1992 Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines. Dopamine 139-147 dopa decarboxylase Homo sapiens 37-41 33808712-1 2021 Aromatic amino acid decarboxylase (AADC) deficiency is a rare, autosomal recessive neurometabolic disorder caused by mutations in the DDC gene, leading to a deficit of AADC, a pyridoxal 5"-phosphate requiring enzyme that catalyzes the decarboxylation of L-Dopa and L-5-hydroxytryptophan in dopamine and serotonin, respectively. Dopamine 290-298 dopa decarboxylase Homo sapiens 35-39 1681453-2 1991 The synthesis and metabolism of dopamine within these hypothalamic neurons were assessed by measuring the accumulation of DOPA after inhibition of DOPA decarboxylase and the concentration of DOPAC in the median eminence. Dopamine 32-40 dopa decarboxylase Homo sapiens 147-165 1688340-1 1991 Monoaminergic neurons use dopa decarboxylase (DDC; aromatic-L-amino-acid carboxy-lyase, EC 4.1.1.28) to form dopamine from L-3,4-dihydroxyphenylalanine (L-dopa). Dopamine 109-117 dopa decarboxylase Homo sapiens 26-44 1688340-1 1991 Monoaminergic neurons use dopa decarboxylase (DDC; aromatic-L-amino-acid carboxy-lyase, EC 4.1.1.28) to form dopamine from L-3,4-dihydroxyphenylalanine (L-dopa). Dopamine 109-117 dopa decarboxylase Homo sapiens 46-49 2166532-2 1990 The enzyme L-amino acid decarboxylase (L-AADC) that converts L-dopa to DA has been localized to the proximal tubule cells with immunocytochemistry. Dopamine 71-73 dopa decarboxylase Homo sapiens 41-45 33808712-1 2021 Aromatic amino acid decarboxylase (AADC) deficiency is a rare, autosomal recessive neurometabolic disorder caused by mutations in the DDC gene, leading to a deficit of AADC, a pyridoxal 5"-phosphate requiring enzyme that catalyzes the decarboxylation of L-Dopa and L-5-hydroxytryptophan in dopamine and serotonin, respectively. Dopamine 290-298 dopa decarboxylase Homo sapiens 168-172 34984873-0 2021 (Heterogeneous expression of DOPA decarboxylase to improve the production of dopamine in Escherichia coli). Dopamine 77-85 dopa decarboxylase Homo sapiens 29-47 34984873-7 2021 To further improve the production of dopamine, a sequence-based homology alignment mining (SHAM) strategy was applied to screen more efficient DOPA decarboxylases, and five DOPA decarboxylase genes were selected from 100 candidates. Dopamine 37-45 dopa decarboxylase Homo sapiens 173-191 34984873-8 2021 In shake-flask fermentation, the DOPA decarboxylase gene from Homo sapiens (Hsddc) showed the highest dopamine production (3.33 g/L), while the DOPA decarboxylase gene from Drosophila Melanogaster (Dmddc) showed the least residual L-DOPA concentration (0.02 g/L). Dopamine 102-110 dopa decarboxylase Homo sapiens 33-51 34253733-1 2021 Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder characterized by deficient synthesis of dopamine and serotonin. Dopamine 121-129 dopa decarboxylase Homo sapiens 0-35 34495420-2 2021 In neuroendocrine tumors, (18F)FDOPA is decarboxylated to (18F)dopamine via the enzyme amino acid decarboxylase (AADC), leading to increased uptake when there is increased AADC activity. Dopamine 63-71 dopa decarboxylase Homo sapiens 113-117 34638785-2 2021 We previously reported that in non-neural cells, angiotensin-1 converting enzyme 2 (ACE2), the gene coding for the SARS-CoV2 host receptor, harbors tight co-expression links with dopa-decarboxylase (DDC), an enzyme involved in the metabolism of dopamine. Dopamine 245-253 dopa decarboxylase Homo sapiens 179-197 34638785-2 2021 We previously reported that in non-neural cells, angiotensin-1 converting enzyme 2 (ACE2), the gene coding for the SARS-CoV2 host receptor, harbors tight co-expression links with dopa-decarboxylase (DDC), an enzyme involved in the metabolism of dopamine. Dopamine 245-253 dopa decarboxylase Homo sapiens 199-202 34495420-2 2021 In neuroendocrine tumors, (18F)FDOPA is decarboxylated to (18F)dopamine via the enzyme amino acid decarboxylase (AADC), leading to increased uptake when there is increased AADC activity. Dopamine 63-71 dopa decarboxylase Homo sapiens 172-176 3119181-1 1987 The local concentration of 6-[18F]fluoro-L-dopa(18F) reflects the activity of aromatic acid decarboxylase (AADC), the enzyme that generates dopamine from its precursor amino acid, L-dopa. Dopamine 140-148 dopa decarboxylase Homo sapiens 78-105 34423296-1 2021 Aromatic l-amino acid decarboxylase (AADC) is an essential dopamine-synthesizing enzyme. Dopamine 59-67 dopa decarboxylase Homo sapiens 0-35 34423296-1 2021 Aromatic l-amino acid decarboxylase (AADC) is an essential dopamine-synthesizing enzyme. Dopamine 59-67 dopa decarboxylase Homo sapiens 37-41 35593933-2 2022 It is due to mutations in the gene coding for the AADC enzyme responsible for the synthesis of dopamine and serotonin. Dopamine 95-103 dopa decarboxylase Homo sapiens 50-54 35546556-9 2022 The second explanation relates to the systemic induction of the enzyme aromatic L-amino acid decarboxylase (AADC), leading to premature conversion of levodopa into dopamine, again limiting the bioavailability within the brain. Dopamine 164-172 dopa decarboxylase Homo sapiens 71-106 35546556-9 2022 The second explanation relates to the systemic induction of the enzyme aromatic L-amino acid decarboxylase (AADC), leading to premature conversion of levodopa into dopamine, again limiting the bioavailability within the brain. Dopamine 164-172 dopa decarboxylase Homo sapiens 108-112 3119181-1 1987 The local concentration of 6-[18F]fluoro-L-dopa(18F) reflects the activity of aromatic acid decarboxylase (AADC), the enzyme that generates dopamine from its precursor amino acid, L-dopa. Dopamine 140-148 dopa decarboxylase Homo sapiens 107-111 3980061-5 1985 (1) An extremely large increase (greater than 100-fold) in dopamine sulfate levels was noted, an increase that was less marked in the same subjects given L-dopa (125 mg) plus the peripheral dopa-decarboxylase inhibitor carbidopa (12.5 mg); as expected, free dopamine concentration also was increased. Dopamine 59-67 dopa decarboxylase Homo sapiens 190-208 3439874-11 1987 Our data suggest a reduction in number of dopaminergic nerve terminals, as the activity of the dopamine synthesizing enzyme DOPA-decarboxylase was also lowered. Dopamine 42-50 dopa decarboxylase Homo sapiens 124-142 3530616-10 1986 The mainstay of therapy is levodopa, which is used in combination with dopa decarboxylase inhibitors to decrease the peripheral conversion of levodopa to dopamine. Dopamine 154-162 dopa decarboxylase Homo sapiens 71-89 20487843-2 1982 Dopamine formed from l-DOPA as substrate was measured for DOPA decarboxylase activity using d-DOPA for the blank. Dopamine 0-8 dopa decarboxylase Homo sapiens 58-76 7162583-7 1982 The positive effect of CDP-choline on parkinsonian patients already treated with L-dopa + dopa decarboxylase inhibitor stands for a possible action on the DA receptor through an activation of the phospholipid metabolism. Dopamine 155-157 dopa decarboxylase Homo sapiens 90-108 6144081-3 1984 To evaluate this possibility, we determined the activity and immunocytochemical localization of the second enzyme in the dopamine biosynthetic pathway, DOPA decarboxylase. Dopamine 121-129 dopa decarboxylase Homo sapiens 152-170 986921-0 1976 [Combined treatment of Parkinsonism with L-dopa and peripheral dopa decarboxylase inhibitors--clinical course of 13 cases and levels of serum/dopa and dopamine]. Dopamine 151-159 dopa decarboxylase Homo sapiens 63-81 6260009-6 1980 We propose that after depletion of dopaminergic terminals, these nonaminergic striatal neurons may contain a large fraction of residual dopa decarboxylase activity and may represent an important locus for conversion of administered dopa to functional dopamine in the parkinsonian corpus striatum. Dopamine 35-43 dopa decarboxylase Homo sapiens 136-154 709823-3 1978 DOPA decarboxylase is used to convert DOPA to dopamine, which concurrently is converted to [3H]-3-O-methyldopamine in the presence of catechol-O-methyltransferase and [methyl-3H]-S-adenosylmethionine and assayed radioenzymatically. Dopamine 46-54 dopa decarboxylase Homo sapiens 0-18 33741988-1 2021 Peripheral decarboxylase inhibitors (PDIs) prevent conversion of levodopa to dopamine in the blood by the enzyme aromatic L-amino acid decarboxylase (AADC). Dopamine 77-85 dopa decarboxylase Homo sapiens 122-148 33741988-1 2021 Peripheral decarboxylase inhibitors (PDIs) prevent conversion of levodopa to dopamine in the blood by the enzyme aromatic L-amino acid decarboxylase (AADC). Dopamine 77-85 dopa decarboxylase Homo sapiens 150-154 33017522-10 2020 RESULTS: Dopamine secretion increased locally in HCC due to an imbalance in dopamine metabolism, including the upregulation of dopa decarboxylase (DDC) and the downregulation of monoamine oxidase A (MAOA). Dopamine 9-17 dopa decarboxylase Homo sapiens 127-145 33734312-1 2021 Aromatic L-amino acid decarboxylase (AADC) deficiency is a complex inherited neurological disorder of monoamine synthesis which results in dopamine and serotonin deficiency. Dopamine 139-147 dopa decarboxylase Homo sapiens 0-35 33734312-1 2021 Aromatic L-amino acid decarboxylase (AADC) deficiency is a complex inherited neurological disorder of monoamine synthesis which results in dopamine and serotonin deficiency. Dopamine 139-147 dopa decarboxylase Homo sapiens 37-41 33734312-8 2021 Bioinformatic and biochemical analyses on recombinant AADC predicted that the activity of one variant could be improved by L-3,4-dihydroxyphenylalanine (L-DOPA) administration; this hypothesis was corroborated in the patient-derived neuronal model, where L-DOPA treatment leads to amelioration of dopamine metabolites. Dopamine 297-305 dopa decarboxylase Homo sapiens 54-58 33218135-7 2020 One of the most used combination drugs for PD is Levodopa-Carbidopa, a dopamine precursor that is converted to dopamine by the action of a naturally occurring enzyme called DOPA decarboxylase. Dopamine 71-79 dopa decarboxylase Homo sapiens 173-191 33218135-7 2020 One of the most used combination drugs for PD is Levodopa-Carbidopa, a dopamine precursor that is converted to dopamine by the action of a naturally occurring enzyme called DOPA decarboxylase. Dopamine 111-119 dopa decarboxylase Homo sapiens 173-191 31104889-1 2019 Aromatic amino acid decarboxylase (AADC) deficiency is a rare autosomal neurometabolic disorder caused by a deficit of AADC, a pyridoxal 5"-phosphate (PLP)-dependent enzyme, which catalyzes the synthesis of dopamine and serotonin. Dopamine 207-215 dopa decarboxylase Homo sapiens 35-39 32149427-1 2020 BACKGROUND: As Parkinson"s disease progresses, levodopa treatment loses efficacy, partly through the loss of the endogenous dopamine-synthesizing enzyme L-amino acid decarboxylase (AADC). Dopamine 124-132 dopa decarboxylase Homo sapiens 153-179 32149427-1 2020 BACKGROUND: As Parkinson"s disease progresses, levodopa treatment loses efficacy, partly through the loss of the endogenous dopamine-synthesizing enzyme L-amino acid decarboxylase (AADC). Dopamine 124-132 dopa decarboxylase Homo sapiens 181-185 31794424-11 2020 Human G cells also express tyrosine hydroxylase and DOPA decarboxylase, enzymes needed to synthesize dopamine. Dopamine 101-109 dopa decarboxylase Homo sapiens 52-70 31387309-1 2019 l-dopa decarboxylase (DDC) that catalyzes the biosynthesis of bioactive amines, such as dopamine and serotonin, is expressed in the nervous system and peripheral tissues, including the liver, where its physiological role remains unknown. Dopamine 88-96 dopa decarboxylase Homo sapiens 0-20 31387309-1 2019 l-dopa decarboxylase (DDC) that catalyzes the biosynthesis of bioactive amines, such as dopamine and serotonin, is expressed in the nervous system and peripheral tissues, including the liver, where its physiological role remains unknown. Dopamine 88-96 dopa decarboxylase Homo sapiens 22-25 31104889-1 2019 Aromatic amino acid decarboxylase (AADC) deficiency is a rare autosomal neurometabolic disorder caused by a deficit of AADC, a pyridoxal 5"-phosphate (PLP)-dependent enzyme, which catalyzes the synthesis of dopamine and serotonin. Dopamine 207-215 dopa decarboxylase Homo sapiens 119-123 30796964-1 2019 L-Dopa decarboxylase (DDC) catalyzes the decarboxylation of L-Dopa to dopamine and 5-hydroxytryptophan (5-HTP) to serotonin. Dopamine 70-78 dopa decarboxylase Homo sapiens 0-20 30796964-1 2019 L-Dopa decarboxylase (DDC) catalyzes the decarboxylation of L-Dopa to dopamine and 5-hydroxytryptophan (5-HTP) to serotonin. Dopamine 70-78 dopa decarboxylase Homo sapiens 22-25 30952622-1 2019 Aromatic-l-amino acid decarboxylase (AADC) deficiency is an ultra-rare inherited autosomal recessive disorder characterized by sharply reduced synthesis of dopamine as well as other neurotransmitters. Dopamine 156-164 dopa decarboxylase Homo sapiens 0-35 30876866-5 2019 Intestinal expression of two enzymes, Tyrosine hydroxylase (TH) and Aromatic Amino acid Decarboxylase (AADC), essential to the transformation of TYR to DA was mapped and the metabolism of metabolism of TYR to DA was traced in human islets and a rodent beta cell line in vitro and from gut to the pancreas in vivo. Dopamine 152-154 dopa decarboxylase Homo sapiens 103-107 30876866-5 2019 Intestinal expression of two enzymes, Tyrosine hydroxylase (TH) and Aromatic Amino acid Decarboxylase (AADC), essential to the transformation of TYR to DA was mapped and the metabolism of metabolism of TYR to DA was traced in human islets and a rodent beta cell line in vitro and from gut to the pancreas in vivo. Dopamine 209-211 dopa decarboxylase Homo sapiens 103-107 30952622-1 2019 Aromatic-l-amino acid decarboxylase (AADC) deficiency is an ultra-rare inherited autosomal recessive disorder characterized by sharply reduced synthesis of dopamine as well as other neurotransmitters. Dopamine 156-164 dopa decarboxylase Homo sapiens 37-41 29686031-1 2018 OBJECTIVES: l-dopa decarboxylase (DDC) is responsible for the synthesis of dopamine. Dopamine 75-83 dopa decarboxylase Homo sapiens 12-32 30018471-9 2018 Upon differentiation, iNPs gave rise to dopamine neuronal-like cells expressing TUJ1, TH, AADC, DAT, VMAT2 and GIRK2. Dopamine 40-48 dopa decarboxylase Homo sapiens 90-94 30911067-0 2019 A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function. Dopamine 101-109 dopa decarboxylase Homo sapiens 46-49 31629395-1 2019 The enzyme L-DOPA decarboxylase (DDC), also called aromatic-L-amino-acid decarboxylase, catalyzes the biosynthesis of dopamine, serotonin, and trace amines. Dopamine 118-126 dopa decarboxylase Homo sapiens 11-31 31629395-1 2019 The enzyme L-DOPA decarboxylase (DDC), also called aromatic-L-amino-acid decarboxylase, catalyzes the biosynthesis of dopamine, serotonin, and trace amines. Dopamine 118-126 dopa decarboxylase Homo sapiens 33-36 30260058-1 2018 Aromatic l-amino acid decarboxylase deficiency (AADCD), attributed to mutations in the dopa decarboxylase (DDC) gene, is a rare neurometabolic disease resulting from a defect in the biosynthesis of dopamine and serotonin. Dopamine 198-206 dopa decarboxylase Homo sapiens 0-35 30260058-1 2018 Aromatic l-amino acid decarboxylase deficiency (AADCD), attributed to mutations in the dopa decarboxylase (DDC) gene, is a rare neurometabolic disease resulting from a defect in the biosynthesis of dopamine and serotonin. Dopamine 198-206 dopa decarboxylase Homo sapiens 87-105 30260058-1 2018 Aromatic l-amino acid decarboxylase deficiency (AADCD), attributed to mutations in the dopa decarboxylase (DDC) gene, is a rare neurometabolic disease resulting from a defect in the biosynthesis of dopamine and serotonin. Dopamine 198-206 dopa decarboxylase Homo sapiens 107-110 29851841-1 2018 RATIONALE: The aromatic L-amino acid decarboxylase (AADC) deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder caused by a deficit of the AADC that is involved in serotonin and dopamine biosynthesis, causing as a consequence, their deficits, but also a lack of norepinephrine and epinephrine, given that dopamine is their precursor. Dopamine 198-206 dopa decarboxylase Homo sapiens 24-50 29851841-1 2018 RATIONALE: The aromatic L-amino acid decarboxylase (AADC) deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder caused by a deficit of the AADC that is involved in serotonin and dopamine biosynthesis, causing as a consequence, their deficits, but also a lack of norepinephrine and epinephrine, given that dopamine is their precursor. Dopamine 198-206 dopa decarboxylase Homo sapiens 52-56 29851841-1 2018 RATIONALE: The aromatic L-amino acid decarboxylase (AADC) deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder caused by a deficit of the AADC that is involved in serotonin and dopamine biosynthesis, causing as a consequence, their deficits, but also a lack of norepinephrine and epinephrine, given that dopamine is their precursor. Dopamine 198-206 dopa decarboxylase Homo sapiens 70-74 29851841-1 2018 RATIONALE: The aromatic L-amino acid decarboxylase (AADC) deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder caused by a deficit of the AADC that is involved in serotonin and dopamine biosynthesis, causing as a consequence, their deficits, but also a lack of norepinephrine and epinephrine, given that dopamine is their precursor. Dopamine 325-333 dopa decarboxylase Homo sapiens 24-50 29851841-1 2018 RATIONALE: The aromatic L-amino acid decarboxylase (AADC) deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder caused by a deficit of the AADC that is involved in serotonin and dopamine biosynthesis, causing as a consequence, their deficits, but also a lack of norepinephrine and epinephrine, given that dopamine is their precursor. Dopamine 325-333 dopa decarboxylase Homo sapiens 52-56 29851841-1 2018 RATIONALE: The aromatic L-amino acid decarboxylase (AADC) deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder caused by a deficit of the AADC that is involved in serotonin and dopamine biosynthesis, causing as a consequence, their deficits, but also a lack of norepinephrine and epinephrine, given that dopamine is their precursor. Dopamine 325-333 dopa decarboxylase Homo sapiens 70-74 29686031-1 2018 OBJECTIVES: l-dopa decarboxylase (DDC) is responsible for the synthesis of dopamine. Dopamine 75-83 dopa decarboxylase Homo sapiens 34-37 28197177-5 2016 Prompted by the above evidence, I hypothesize that dopamine and serotonin could be synthesized sequentially in two monoenzymatic cells in the spinal cord via a TH-AADC and a TPH-AADC cascade respectively. Dopamine 51-59 dopa decarboxylase Homo sapiens 163-167 29356298-1 2018 Aromatic amino acid or Dopa decarboxylase (AADC or DDC) is a homodimeric pyridoxal 5"-phosphate (PLP) enzyme responsible for the generation of the neurotransmitters dopamine and serotonin. Dopamine 165-173 dopa decarboxylase Homo sapiens 23-41 29356298-1 2018 Aromatic amino acid or Dopa decarboxylase (AADC or DDC) is a homodimeric pyridoxal 5"-phosphate (PLP) enzyme responsible for the generation of the neurotransmitters dopamine and serotonin. Dopamine 165-173 dopa decarboxylase Homo sapiens 43-47 29356298-1 2018 Aromatic amino acid or Dopa decarboxylase (AADC or DDC) is a homodimeric pyridoxal 5"-phosphate (PLP) enzyme responsible for the generation of the neurotransmitters dopamine and serotonin. Dopamine 165-173 dopa decarboxylase Homo sapiens 51-54 29356298-2 2018 AADC deficiency is a rare inborn disease caused by mutations of the AADC gene leading to a defect of AADC enzyme and resulting in impaired dopamine and serotonin synthesis. Dopamine 139-147 dopa decarboxylase Homo sapiens 0-4 29356298-2 2018 AADC deficiency is a rare inborn disease caused by mutations of the AADC gene leading to a defect of AADC enzyme and resulting in impaired dopamine and serotonin synthesis. Dopamine 139-147 dopa decarboxylase Homo sapiens 68-72 28431168-6 2017 More importantly, we demonstrated that the genetic variations of the aromatic-L-amino-acid decarboxylase (DDC) gene, which is involved in the synthesis of both dopamine and serotonin, contributed to individual differences in the susceptibility to framing. Dopamine 160-168 dopa decarboxylase Homo sapiens 106-109 28166239-1 2017 In Parkinson"s disease (PD), aromatic L-amino acid decarboxylase (AADC) is the rate-limiting enzyme in the conversion of L-DOPA (Sinemet) to dopamine (DA). Dopamine 141-149 dopa decarboxylase Homo sapiens 38-64 28166239-1 2017 In Parkinson"s disease (PD), aromatic L-amino acid decarboxylase (AADC) is the rate-limiting enzyme in the conversion of L-DOPA (Sinemet) to dopamine (DA). Dopamine 141-149 dopa decarboxylase Homo sapiens 66-70 28166239-1 2017 In Parkinson"s disease (PD), aromatic L-amino acid decarboxylase (AADC) is the rate-limiting enzyme in the conversion of L-DOPA (Sinemet) to dopamine (DA). Dopamine 151-153 dopa decarboxylase Homo sapiens 38-64 28166239-1 2017 In Parkinson"s disease (PD), aromatic L-amino acid decarboxylase (AADC) is the rate-limiting enzyme in the conversion of L-DOPA (Sinemet) to dopamine (DA). Dopamine 151-153 dopa decarboxylase Homo sapiens 66-70 28166239-2 2017 Previous studies in PD animal models demonstrated that lesion of dopaminergic neurons is associated with profound loss of AADC activity in the striatum, blocking efficient conversion of L-DOPA to DA. Dopamine 196-198 dopa decarboxylase Homo sapiens 122-126 28100251-1 2017 Aromatic L-amino acid decarboxylase deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder that leads to a severe combined deficiency of serotonin, dopamine, norepinephrine and epinephrine. Dopamine 167-175 dopa decarboxylase Homo sapiens 0-35 27769832-1 2016 Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. Dopamine 183-191 dopa decarboxylase Homo sapiens 60-63 28197177-5 2016 Prompted by the above evidence, I hypothesize that dopamine and serotonin could be synthesized sequentially in two monoenzymatic cells in the spinal cord via a TH-AADC and a TPH-AADC cascade respectively. Dopamine 51-59 dopa decarboxylase Homo sapiens 178-182 27622543-1 2016 Through its conversion to dopamine by aromatic l-amino acid decarboxylase (AADC), l-3,4-dihydroxyphenylalanine (l-DOPA) replenishes depleted brain dopamine in Parkinson"s disease patients. Dopamine 26-34 dopa decarboxylase Homo sapiens 47-73 27622543-1 2016 Through its conversion to dopamine by aromatic l-amino acid decarboxylase (AADC), l-3,4-dihydroxyphenylalanine (l-DOPA) replenishes depleted brain dopamine in Parkinson"s disease patients. Dopamine 26-34 dopa decarboxylase Homo sapiens 75-79 27622543-1 2016 Through its conversion to dopamine by aromatic l-amino acid decarboxylase (AADC), l-3,4-dihydroxyphenylalanine (l-DOPA) replenishes depleted brain dopamine in Parkinson"s disease patients. Dopamine 147-155 dopa decarboxylase Homo sapiens 47-73 27622543-1 2016 Through its conversion to dopamine by aromatic l-amino acid decarboxylase (AADC), l-3,4-dihydroxyphenylalanine (l-DOPA) replenishes depleted brain dopamine in Parkinson"s disease patients. Dopamine 147-155 dopa decarboxylase Homo sapiens 75-79 27371992-2 2016 AADC catalyzes the synthesis of the neurotransmitters dopamine and serotonin from l-dopa and 5-HT respectively. Dopamine 54-62 dopa decarboxylase Homo sapiens 0-4 26924680-1 2016 The synthesis of multiple amine neurotransmitters, such as dopamine, norepinephrine, serotonin, and trace amines, relies in part on DOPA decarboxylase (DDC, AADC), an enzyme that is required for normative neural operations. Dopamine 59-67 dopa decarboxylase Homo sapiens 132-150 26924680-1 2016 The synthesis of multiple amine neurotransmitters, such as dopamine, norepinephrine, serotonin, and trace amines, relies in part on DOPA decarboxylase (DDC, AADC), an enzyme that is required for normative neural operations. Dopamine 59-67 dopa decarboxylase Homo sapiens 152-155 26924680-1 2016 The synthesis of multiple amine neurotransmitters, such as dopamine, norepinephrine, serotonin, and trace amines, relies in part on DOPA decarboxylase (DDC, AADC), an enzyme that is required for normative neural operations. Dopamine 59-67 dopa decarboxylase Homo sapiens 157-161