PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33550481-12 2021 Modulation in cortical levels of histamine, norepinephrine and dopamine provides the neurochemical basis for wake-promoting and anticataplectic effects observed in orexin knockout mice. Dopamine 63-71 hypocretin Mus musculus 164-170 19703479-5 2010 In the present study, locomotor activity in a novel environment and dopamine turnover was significantly decreased in orexin-deficient mice compared to WT mice, which suggests that psychostimulants may be useful for maintaining wakefulness in orexin deficiency. Dopamine 68-76 hypocretin Mus musculus 117-123 16611835-2 2006 In the present study, we show that NA, dopamine, and adrenaline all directly hyperpolarized orexin neurons. Dopamine 39-47 hypocretin Mus musculus 92-98 16611835-1 2006 We reported elsewhere that orexin neurons are directly hyperpolarized by noradrenaline (NA) and dopamine. Dopamine 96-104 hypocretin Mus musculus 27-33 16407535-3 2006 The levels of dopamine and its major metabolites in the nucleus accumbens were markedly increased by the microinjection of orexin A and orexin B into the VTA. Dopamine 14-22 hypocretin Mus musculus 123-131 16407535-3 2006 The levels of dopamine and its major metabolites in the nucleus accumbens were markedly increased by the microinjection of orexin A and orexin B into the VTA. Dopamine 14-22 hypocretin Mus musculus 136-144 16407535-6 2006 Furthermore, the increased level of dialysate dopamine produced by morphine in the mouse brain was significantly decreased by deletion of the prepro-orexin gene. Dopamine 46-54 hypocretin Mus musculus 142-155 16407535-7 2006 These findings provide new evidence that orexin-containing neurons in the VTA are directly implicated in the rewarding effect and hyperlocomotion induced by morphine through activation of the mesolimbic dopamine pathway in rodents. Dopamine 203-211 hypocretin Mus musculus 41-47 30465812-9 2019 Finally, in vivo microdialysis experiments showed that amphetamine potentiated orexin A-induced dopamine and glutamate release in the ventral tegmental area (VTA). Dopamine 96-104 hypocretin Mus musculus 79-87 30524223-6 2018 The results from animal experiments demonstrated that orexin-A attenuated the loss of dopaminergic neurons and the decrease of tyrosine hydroxylase (TH) expression in the substantia nigra, normalized the striatal dopaminergic fibers, and prevented the depletion of dopamine and its metabolites in the striatum. Dopamine 86-94 hypocretin Mus musculus 54-62 27480648-0 2017 Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine. Dopamine 66-74 hypocretin Mus musculus 0-17 27480648-1 2017 The hypocretin/orexin (HCRT) system is implicated in reward and reinforcement processes through actions on the mesolimbic dopamine (DA) system. Dopamine 122-130 hypocretin Mus musculus 4-21 27480648-1 2017 The hypocretin/orexin (HCRT) system is implicated in reward and reinforcement processes through actions on the mesolimbic dopamine (DA) system. Dopamine 122-130 hypocretin Mus musculus 23-27 27480648-1 2017 The hypocretin/orexin (HCRT) system is implicated in reward and reinforcement processes through actions on the mesolimbic dopamine (DA) system. Dopamine 132-134 hypocretin Mus musculus 4-21 27480648-1 2017 The hypocretin/orexin (HCRT) system is implicated in reward and reinforcement processes through actions on the mesolimbic dopamine (DA) system. Dopamine 132-134 hypocretin Mus musculus 23-27 27480648-2 2017 Here we provide evidence for the relationship between HCRT and DA in vivo in anesthetized and freely moving mice. Dopamine 63-65 hypocretin Mus musculus 54-58 27480648-4 2017 Using a combination of microdialysis and in vivo fast scan cyclic voltammetry in anesthetized and freely moving mice, we investigated the underlying role of HCRT in the regulation of DA release and uptake. Dopamine 183-185 hypocretin Mus musculus 157-161 28178514-0 2017 Projection-Target-Defined Effects of Orexin and Dynorphin on VTA Dopamine Neurons. Dopamine 65-73 hypocretin Mus musculus 37-43 28178514-2 2017 We tested the actions of co-expressed lateral hypothalamic peptides, orexin A (oxA) and dynorphin (dyn), on projection-target-defined dopamine neurons in mice. Dopamine 134-142 hypocretin Mus musculus 69-77 28178514-5 2017 OxA selectively increased firing in lAcbSh- and mAcbSh-projecting dopamine neurons. Dopamine 66-74 hypocretin Mus musculus 0-3 26500842-3 2015 Stimulatory and inhibitory leptin actions on dopamine neurons have been reported, e.g. by indirect actions on orexin neurons or via direct innervation of dopamine neurons in the ventral tegmental area. Dopamine 45-53 hypocretin Mus musculus 110-116 24466352-4 2014 We also found that: i- HFD-mediated orosensory stimulation was required for the mesolimbic pathway activation, ii- acute HFD differentially activates dopamine neurons of the paranigral, parabrachial pigmented and interfascicular sub-regions of the VTA, and iii- orexin neurons of the lateral hypothalamic area are responsive to acute HFD. Dopamine 150-158 hypocretin Mus musculus 262-268 25107627-1 2014 Lateral hypothalamic area (LHA) orexin neurons modulate reward-based feeding by activating ventral tegmental area (VTA) dopamine (DA) neurons. Dopamine 120-128 hypocretin Mus musculus 32-38 25107627-1 2014 Lateral hypothalamic area (LHA) orexin neurons modulate reward-based feeding by activating ventral tegmental area (VTA) dopamine (DA) neurons. Dopamine 130-132 hypocretin Mus musculus 32-38