PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15450100-2 2004 Both purinergic and cannabinoid systems interact with dopamine neurotransmission (through A2A and CB1 receptors, respectively). Dopamine 54-62 cannabinoid receptor 1 (brain) Mus musculus 98-101 15742004-12 2005 Acute cocaine administration induced a similar enhancement in the extracellular levels of dopamine in the nucleus accumbens of both CB1 knockout and wild-type mice. Dopamine 90-98 cannabinoid receptor 1 (brain) Mus musculus 132-135 33613258-5 2021 In fact, by retrograde signaling to cannabinoid receptor type 1 (CB1R) at inhibitory inputs to DA neurons, 2-AG inhibited GABA release thus inducing an increase in DA concentration in the VTA and NAc of ob/ob mice. Dopamine 95-97 cannabinoid receptor 1 (brain) Mus musculus 36-63 11399112-3 2001 In the temporal domain, cannabinoid receptor gene (CB1) knockout mice exhibit behavioural alterations, which parallel symptoms in schizophrenia, cannabis intoxication and dopamine D2 activation. Dopamine 171-179 cannabinoid receptor 1 (brain) Mus musculus 51-54 11823058-2 2002 Together with overlapping expression patterns of dopamine and serotonin receptors this suggests a potential of CB1 to modulate the function of the dopamine and serotonin system. Dopamine 49-57 cannabinoid receptor 1 (brain) Mus musculus 111-114 11823058-2 2002 Together with overlapping expression patterns of dopamine and serotonin receptors this suggests a potential of CB1 to modulate the function of the dopamine and serotonin system. Dopamine 147-155 cannabinoid receptor 1 (brain) Mus musculus 111-114 34638827-4 2021 Pretreatment with a synthetic cannabinoid, JWH-210 (CB1 agonist), increased METH-induced CPP score and METH-induced dopamine release in acute striatal slices. Dopamine 116-124 cannabinoid receptor 1 (brain) Mus musculus 52-55 35361667-3 2022 We examined postnatal CB1R expression in the major striatonigral circuit from striosomes of the striatum to the dopamine-containing neurons of the substantia nigra. Dopamine 112-120 cannabinoid receptor 1 (brain) Mus musculus 22-26 35361667-6 2022 Our finding that CB1R plays a major role in postnatal wiring of the striatonigral dopamine-control system, with lasting consequences at least in mice, points to a crucial need to determine whether lactating mothers" use of CB1R agonists (e.g., in marijuana) or antagonists (e.g., type 2 diabetes therapies) can disrupt brain development in nursing offspring.Significance StatementWe report the surprising finding that cannabinoid receptor 1 (CB1R), which mediates the psychoactive effects of marijuana, is required for normal postnatal development of midbrain dopamine-containing neurons and their striatal inputs in mice. Dopamine 82-90 cannabinoid receptor 1 (brain) Mus musculus 17-21 35361667-6 2022 Our finding that CB1R plays a major role in postnatal wiring of the striatonigral dopamine-control system, with lasting consequences at least in mice, points to a crucial need to determine whether lactating mothers" use of CB1R agonists (e.g., in marijuana) or antagonists (e.g., type 2 diabetes therapies) can disrupt brain development in nursing offspring.Significance StatementWe report the surprising finding that cannabinoid receptor 1 (CB1R), which mediates the psychoactive effects of marijuana, is required for normal postnatal development of midbrain dopamine-containing neurons and their striatal inputs in mice. Dopamine 560-568 cannabinoid receptor 1 (brain) Mus musculus 17-21 35361667-8 2022 Mice with a mutation in the gene that encodes CB1R show abnormal striatonigral connections and displaced dopamine neurons indicating a postnatal function for CB1R in brain development. Dopamine 105-113 cannabinoid receptor 1 (brain) Mus musculus 46-50 35361667-8 2022 Mice with a mutation in the gene that encodes CB1R show abnormal striatonigral connections and displaced dopamine neurons indicating a postnatal function for CB1R in brain development. Dopamine 105-113 cannabinoid receptor 1 (brain) Mus musculus 158-162 35075269-7 2022 Selective inhibition of peripheral CB1 receptors resulted in a vagus-dependent increased hypothalamic activity, modified metabolic efficiency, and dampened activity of mesolimbic dopamine circuit, altogether leading to the suppression of palatable eating. Dopamine 179-187 cannabinoid receptor 1 (brain) Mus musculus 35-38 33617930-3 2021 VTA dopamine cells are regulated by local inhibitory GABA cells, which exhibit a form of pre-synaptic cannabinoid receptor 1-dependent long-term depression of their glutamatergic inputs. Dopamine 4-12 cannabinoid receptor 1 (brain) Mus musculus 102-124 33613258-5 2021 In fact, by retrograde signaling to cannabinoid receptor type 1 (CB1R) at inhibitory inputs to DA neurons, 2-AG inhibited GABA release thus inducing an increase in DA concentration in the VTA and NAc of ob/ob mice. Dopamine 95-97 cannabinoid receptor 1 (brain) Mus musculus 65-69 33613258-5 2021 In fact, by retrograde signaling to cannabinoid receptor type 1 (CB1R) at inhibitory inputs to DA neurons, 2-AG inhibited GABA release thus inducing an increase in DA concentration in the VTA and NAc of ob/ob mice. Dopamine 164-166 cannabinoid receptor 1 (brain) Mus musculus 36-63 33613258-5 2021 In fact, by retrograde signaling to cannabinoid receptor type 1 (CB1R) at inhibitory inputs to DA neurons, 2-AG inhibited GABA release thus inducing an increase in DA concentration in the VTA and NAc of ob/ob mice. Dopamine 164-166 cannabinoid receptor 1 (brain) Mus musculus 65-69 30476795-14 2019 In addition, the pharmacological blockage of CB1 receptor in stressed mice deregulated the expression of dopamine receptors and might lead to dysfunctions in dopamine metabolism. Dopamine 105-113 cannabinoid receptor 1 (brain) Mus musculus 45-48 33036015-9 2021 The data demonstrate for the first time that a CB1R allosteric modulator ameliorates the behavioral deficits in two model of increased dopamine, warranting further investigation as a potential therapeutic target in psychiatry. Dopamine 135-143 cannabinoid receptor 1 (brain) Mus musculus 47-51 22592925-3 2012 The effects of CB1R deletion on PL parvalbumin interneurons may be ascribed to loss of CB1R-mediated retrograde signaling on mesocortical dopamine transmission, and, in turn, altered expression and/or subcellular distribution of D2R in the PL. Dopamine 138-146 cannabinoid receptor 1 (brain) Mus musculus 15-19 28630452-8 2018 Indeed, acute pharmacological blockade of CB1 receptors was sufficient to rescue the altered remote memory recall in COMT-Val-tg mice and increased PFC dopamine levels. Dopamine 152-160 cannabinoid receptor 1 (brain) Mus musculus 42-45 29466446-9 2018 Dense CB1-R-expressing striatonigral fibers extend dorsally within the substantia nigra pars reticulata, and colocalize with bundles of ventrally extending, striosome-targeted, dendrites of dopamine-containing neurons in the substantia nigra pars compacta (striosome-dendron bouquets). Dopamine 190-198 cannabinoid receptor 1 (brain) Mus musculus 6-11 29466446-12 2018 These data suggest a role for CB1-Rs in caudal dorsolateral striosome collaterals and striosome-dendron bouquet projections to lateral substantia nigra, where they are anatomically poised to mediate presynaptic disinhibition of both striosomal MSNs and midbrain dopamine neurons in response to endocannabinoids and cannabinomimetics. Dopamine 262-270 cannabinoid receptor 1 (brain) Mus musculus 30-33 26498506-0 2016 Dopamine-dependent CB1 receptor dysfunction at corticostriatal synapses in homozygous PINK1 knockout mice. Dopamine 0-8 cannabinoid receptor 1 (brain) Mus musculus 19-22 24345819-9 2014 We further demonstrate that WIN 55,212-2 dose-dependently increases dopamine release and accelerates a temporal behavioral response pattern in a CB1 receptor-dependent manner--suggesting that cannabinoid receptor activation modifies timing behavior, in part, by augmenting time-engendered patterns of dopamine release. Dopamine 301-309 cannabinoid receptor 1 (brain) Mus musculus 145-148 22592925-3 2012 The effects of CB1R deletion on PL parvalbumin interneurons may be ascribed to loss of CB1R-mediated retrograde signaling on mesocortical dopamine transmission, and, in turn, altered expression and/or subcellular distribution of D2R in the PL. Dopamine 138-146 cannabinoid receptor 1 (brain) Mus musculus 87-91 22160162-1 2012 RATIONALE: The nucleus accumbens (Acb) shell and caudate-putamen nucleus (CPu) are respectively implicated in the motivational and motor effects of dopamine, which are mediated in part through dopamine D2-like receptors (D2Rs) and modulated by activation of the cannabinoid-1 receptor (CB1R). Dopamine 148-156 cannabinoid receptor 1 (brain) Mus musculus 262-284 22586226-3 2012 We combined optical and electrophysiology recordings in murine slice preparations from CB1 receptor-null mice and green fluorescent protein hemizygotic bacterial artificial chromosome transgenic mice to show how dopamine regulates glutamatergic synapses specific to the striatonigral and striatopallidal basal ganglia pathways. Dopamine 212-220 cannabinoid receptor 1 (brain) Mus musculus 87-90 22160162-1 2012 RATIONALE: The nucleus accumbens (Acb) shell and caudate-putamen nucleus (CPu) are respectively implicated in the motivational and motor effects of dopamine, which are mediated in part through dopamine D2-like receptors (D2Rs) and modulated by activation of the cannabinoid-1 receptor (CB1R). Dopamine 148-156 cannabinoid receptor 1 (brain) Mus musculus 286-290 20554863-5 2010 The action of BDNF on CB(1)R(GABA) function was tyrosine kinase dependent and was complete even after receptor sensitization with cocaine or environmental manipulations activating the dopamine (DA)-dependent reward system. Dopamine 184-192 cannabinoid receptor 1 (brain) Mus musculus 22-34 22034972-5 2011 In DAT-CI mice, the blockade of CB1R((GABA)) function was complete even after cocaine or environmental manipulations activating the endogenous DA-dependent reward system, which are known to sensitize these receptors in control animals. Dopamine 3-5 cannabinoid receptor 1 (brain) Mus musculus 32-36 21887137-9 2011 Most strikingly, D1-CB1(-/-) mice exhibited significantly increased contextual and auditory-cued fear, with attenuated within session extinction, suggesting that a specific reduction of endocannabinoid signaling in neurons expressing dopamine D1Rs is able to affect acute fear adaptation. Dopamine 234-242 cannabinoid receptor 1 (brain) Mus musculus 20-23 20939059-1 2010 Cannabinoid-type 1 (CB1) receptors are implicated in mu-opioid receptor (mu-OR)-dependent reward ascribed partially to mesolimbic dopamine release in the nucleus accumbens (Acb) shell. Dopamine 130-138 cannabinoid receptor 1 (brain) Mus musculus 0-23 20939059-2 2010 Thus, CB1 receptor gene deletion may preferentially alter the availability of mu-ORs and/or dopamine innervation in this brain region, which is functionally distinct from the motor-associated Acb core. Dopamine 92-100 cannabinoid receptor 1 (brain) Mus musculus 6-9 20939059-9 2010 Our results indicate that constitutive deletion of the CB1 receptor gene has a major impact on the pre and postsynaptic availability of mu-ORs at axospinous synapses and on the dopamine innervation of the Acb shell as well as the dendritic surface expression of mu-ORs in Acb core of mature rodents. Dopamine 177-185 cannabinoid receptor 1 (brain) Mus musculus 55-58 20554863-5 2010 The action of BDNF on CB(1)R(GABA) function was tyrosine kinase dependent and was complete even after receptor sensitization with cocaine or environmental manipulations activating the dopamine (DA)-dependent reward system. Dopamine 194-196 cannabinoid receptor 1 (brain) Mus musculus 22-34 19524019-14 2009 Decreases are also apparent in the ligand binding of neuronal D1 and D2 dopamine receptors co-located with CB1, while there is no change in GABA(A) receptor ligand binding. Dopamine 72-80 cannabinoid receptor 1 (brain) Mus musculus 107-110 18493584-6 2008 Amperometry-detected increases in evoked dopamine (DA) release by the CB1-R antagonist in nucleus accumbens slices indicates that AM251 modulates DA release from VTA terminals. Dopamine 41-49 cannabinoid receptor 1 (brain) Mus musculus 70-75 18493584-6 2008 Amperometry-detected increases in evoked dopamine (DA) release by the CB1-R antagonist in nucleus accumbens slices indicates that AM251 modulates DA release from VTA terminals. Dopamine 51-53 cannabinoid receptor 1 (brain) Mus musculus 70-75