PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34073405-0 2021 Evaluation of Substituted N-Phenylpiperazine Analogs as D3 vs. D2 Dopamine Receptor Subtype Selective Ligands. phenylpiperazine 26-44 dopamine receptor D2 Homo sapiens 63-83 34073405-1 2021 N-phenylpiperazine analogs can bind selectively to the D3 versus the D2 dopamine receptor subtype despite the fact that these two D2-like dopamine receptor subtypes exhibit substantial amino acid sequence homology. phenylpiperazine 0-18 dopamine receptor D2 Homo sapiens 69-89 33988991-3 2021 Here, we examine the molecular basis for the high affinity D3R binding and D3R vs D2R binding selectivity of substituted phenylpiperazine thiopheneamides. phenylpiperazine 121-137 dopamine receptor D2 Homo sapiens 82-85 31214037-1 2019 LASSBio-579, an N-phenylpiperazine antipsychotic lead compound, has been previously reported as a D2 receptor (D2R) ligand with antipsychotic-like activities in rodent models of schizophrenia. phenylpiperazine 16-34 dopamine receptor D2 Homo sapiens 98-109 31214037-1 2019 LASSBio-579, an N-phenylpiperazine antipsychotic lead compound, has been previously reported as a D2 receptor (D2R) ligand with antipsychotic-like activities in rodent models of schizophrenia. phenylpiperazine 16-34 dopamine receptor D2 Homo sapiens 111-114 30010318-3 2018 Our goal was to investigate how the composition and size of the nonaromatic ring structure at the piperazine position of substituted phenylpiperazine analogues might influence binding affinity at the human D2 and D3 dopamine receptors. phenylpiperazine 133-149 dopamine receptor D2 Homo sapiens 206-234