PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16919461-0 2006 Novel potent neuropeptide Y Y5 receptor antagonists: synthesis and structure-activity relationships of phenylpiperazine derivatives. phenylpiperazine 103-119 neuropeptide Y receptor Y5 Homo sapiens 28-39 16919461-1 2006 A series of phenylpiperazine derivatives were synthesized and evaluated for their neuropeptide Y (NPY) Y5 receptor antagonistic activities. phenylpiperazine 12-28 neuropeptide Y receptor Y5 Homo sapiens 82-114 16919461-3 2006 Subsequent optimization of the phenylpiperazine template by substitution of the phenyl moiety resulted in a series of (2-methanesulfonamidephenyl)piperazine derivatives that showed potent binding affinity and antagonistic activity for the Y5 receptor. phenylpiperazine 31-47 neuropeptide Y receptor Y5 Homo sapiens 239-250