PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9436302-0 1997 Structure and serotonin 5-HT2C receptor activity of ortho- and meta-substituted phenylpiperazines. phenylpiperazine 80-97 5-hydroxytryptamine receptor 2C Homo sapiens 14-39 9436302-1 1997 The structural characteristics of ortho- and meta-substituted phenylpiperazines have been investigated in order to understand their actions at the serotonin 5-HT2C receptor. phenylpiperazine 62-79 5-hydroxytryptamine receptor 2C Homo sapiens 147-172 9436302-4 1997 The activities of several phenylpiperazines, in combination with their crystal structures and conformational characteristics, lead to the hypothesis that the conformation for which the piperazine ring and the phenyl ring are approximately co-planar should be the 5-HT2C receptor "activating" conformation. phenylpiperazine 26-43 5-hydroxytryptamine receptor 2C Homo sapiens 263-269 8748393-2 1995 Three structural classes of compounds have been described to stimulate increases in phosphoinositide (PI) hydrolysis at the 5-HT2C receptor site: phenylpiperazines, phenylalkylamines, and indolamines. phenylpiperazine 146-163 5-hydroxytryptamine receptor 2C Homo sapiens 124-130