PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26914862-1	2016	The comprehensive structure-activity relationships of triantennary GalNAc conjugated ASOs for enhancing potency via ASGR mediated delivery to hepatocytes is reported.	N-acetylgalactosaminuronic acid	67-73	asialoglycoprotein receptor 1	Mus musculus	116-120	
31303442-3	2019	One example is the targeted delivery of ASOs to hepatocytes, achieved with N-acetylgalactosamine (GalNAc) conjugation to ASO, which results in selective uptake by asialoglycoprotein receptor (ASGR).	N-acetylgalactosaminuronic acid	98-104	asialoglycoprotein receptor 1	Mus musculus	192-196	
31303442-5	2019	The activity of GalNAc-conjugated ASOs was superior to that of the unconjugated parental ASO in ASGR (+) human HCC cells in vitro, but not in ASGR (-) cells.	N-acetylgalactosaminuronic acid	16-22	asialoglycoprotein receptor 1	Mus musculus	96-100	
27268307-2	2016	Trivalent GalNAc is a high affinity ligand for the asialoglycoprotein receptor (ASGR)-a C-type lectin expressed almost exclusively on hepatocytes in the liver.	N-acetylgalactosaminuronic acid	10-16	asialoglycoprotein receptor 1	Mus musculus	51-78	
27268307-2	2016	Trivalent GalNAc is a high affinity ligand for the asialoglycoprotein receptor (ASGR)-a C-type lectin expressed almost exclusively on hepatocytes in the liver.	N-acetylgalactosaminuronic acid	10-16	asialoglycoprotein receptor 1	Mus musculus	80-84	
28158620-0	2017	Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor.	N-acetylgalactosaminuronic acid	29-35	asialoglycoprotein receptor 1	Mus musculus	114-141	
28158620-4	2017	Two and three GalNAc conjugated single stranded ASOs bind the ASGR with the strongest affinity and display optimal in vitro and in vivo activities.	N-acetylgalactosaminuronic acid	14-20	asialoglycoprotein receptor 1	Mus musculus	62-66	
28158620-5	2017	1 GalNAc conjugated ASOs showed 10-fold reduced ASGR binding affinity relative to three GalNAc ASOs but only 2-fold reduced activity in mice.	N-acetylgalactosaminuronic acid	2-8	asialoglycoprotein receptor 1	Mus musculus	48-52	
28158620-6	2017	An unexpected observation was that the ASGR also appears to play a role in the uptake of unconjugated phosphorothioate modified ASOs in the liver as evidenced by the loss of activity of GalNAc conjugated and unconjugated ASOs in ASGR knockout mice.	N-acetylgalactosaminuronic acid	186-192	asialoglycoprotein receptor 1	Mus musculus	39-43