PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11456500-6 2001 Intramolecular deuterium isotope effects for the benzylic hydroxylation of o-xylene-alpha-(2)H(3), p-xylene-alpha-(2)H(3), 2-(2)H(3),6-dimethylnaphthalene, and 4-(2)H(3),4"-dimethylbiphenyl were determined for CYP4B1 and CYP2B1 to further map their active site dimensions. Deuterium 15-24 cytochrome P450 4B1 Oryctolagus cuniculus 210-216 11456500-9 2001 Isotope effects for the CYP4B1-mediated benzylic hydroxylation of o- and p-xylenes were fully expressed (k(H)/k(D) = 9.7 and 6.8, respectively), whereas deuterium isotope effects for the naphthyl and biphenyl derivatives were both substantially masked (k(H)/k(D) approximately equal to 1). Deuterium 153-162 cytochrome P450 4B1 Oryctolagus cuniculus 24-30