PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30008470-5 2019 Long-term voluntary consumption of excessive alcohol quantities (~10-15 g/kg/24 h, 5 weeks) increased Adnp mRNA in the hippocampus of male mice immediately after an alcohol-drinking session, but the level returned to baseline after 24 h of withdrawal. Alcohols 45-52 activity-dependent neuroprotective protein Mus musculus 102-106 30008470-5 2019 Long-term voluntary consumption of excessive alcohol quantities (~10-15 g/kg/24 h, 5 weeks) increased Adnp mRNA in the hippocampus of male mice immediately after an alcohol-drinking session, but the level returned to baseline after 24 h of withdrawal. Alcohols 165-172 activity-dependent neuroprotective protein Mus musculus 102-106 30008470-6 2019 In contrast, excessive alcohol consumption in females led to long-lasting reduction in hippocampal Adnp expression. Alcohols 23-30 activity-dependent neuroprotective protein Mus musculus 99-103 30008470-7 2019 We further tested the regulatory role of Adnp in alcohol consumption, using the Adnp haploinsufficient mouse model. Alcohols 49-56 activity-dependent neuroprotective protein Mus musculus 41-45 30008470-8 2019 We found that Adnp haploinsufficient female mice showed higher alcohol consumption and preference, compared to Adnp intact females, whereas no genotype difference was observed in males. Alcohols 63-70 activity-dependent neuroprotective protein Mus musculus 14-18 30008470-9 2019 Importantly, daily intranasal administration of the ADNP-snippet drug candidate NAP normalized alcohol consumption in Adnp haploinsufficient females. Alcohols 95-102 activity-dependent neuroprotective protein Mus musculus 52-56 30008470-10 2019 Finally, female Adnp haploinsufficient mice showed a sharp increase in alcohol intake after abstinence, suggesting that Adnp protects against relapse in females. Alcohols 71-78 activity-dependent neuroprotective protein Mus musculus 16-20 30008470-11 2019 The current data suggest that ADNP is a potential novel biomarker and negative regulator of alcohol-drinking behaviors. Alcohols 92-99 activity-dependent neuroprotective protein Mus musculus 30-34 30008470-0 2019 Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice. Alcohols 56-63 activity-dependent neuroprotective protein Mus musculus 0-42 30008470-0 2019 Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice. Alcohols 56-63 activity-dependent neuroprotective protein Mus musculus 44-48 30008470-0 2019 Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice. Alcohols 106-113 activity-dependent neuroprotective protein Mus musculus 0-42 30008470-0 2019 Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice. Alcohols 106-113 activity-dependent neuroprotective protein Mus musculus 44-48 30008470-3 2019 Here, we discovered that alcohol exposure regulates Adnp expression in the mesolimbic system, and that Adnp keeps alcohol drinking in moderation, in a sex-dependent manner. Alcohols 25-32 activity-dependent neuroprotective protein Mus musculus 52-56 30008470-3 2019 Here, we discovered that alcohol exposure regulates Adnp expression in the mesolimbic system, and that Adnp keeps alcohol drinking in moderation, in a sex-dependent manner. Alcohols 114-121 activity-dependent neuroprotective protein Mus musculus 103-107 30008470-4 2019 Specifically, Sub-chronic alcohol treatment (2.5 g/kg/day for 7 days) increased Adnp mRNA levels in the dorsal hippocampus in both sexes, and in the nucleus accumbens of female mice, 24 h after the last alcohol injection. Alcohols 26-33 activity-dependent neuroprotective protein Mus musculus 80-84 19073235-0 2009 Activity-dependent neuroprotective protein-derived peptide, NAP, preventing alcohol-induced apoptosis in fetal brain of C57BL/6 mouse. Alcohols 76-83 activity-dependent neuroprotective protein Mus musculus 0-42 19073235-3 2009 This peptide with the sequence NAPVSIPQ, known as NAP, a fragment of activity-dependent neuroprotective protein, demonstrated a potent protective effect against oxidative stress associated with alcohol exposure. Alcohols 194-201 activity-dependent neuroprotective protein Mus musculus 69-111 14526315-2 2003 Peptides NAPVSIPQ (NAP) and SALLRSIPA (SAL), related to activity-dependent neuroprotective protein (ADNP), prevent alcohol-induced damage in a mouse model of FAS. Alcohols 115-122 activity-dependent neuroprotective protein Mus musculus 56-98 14526315-2 2003 Peptides NAPVSIPQ (NAP) and SALLRSIPA (SAL), related to activity-dependent neuroprotective protein (ADNP), prevent alcohol-induced damage in a mouse model of FAS. Alcohols 115-122 activity-dependent neuroprotective protein Mus musculus 100-104 14526315-10 2003 At 24 hours, there was an increase in ADNP in alcohol-exposed embryos compared with controls (P<.001); these findings persisted at 10 days (P<.001). Alcohols 46-53 activity-dependent neuroprotective protein Mus musculus 38-42 14526315-12 2003 At 24 hours, there was greater ADNP in alcohol-exposed decidua compared with controls (P<.001), which did not persist at 10 days (P=.97). Alcohols 39-46 activity-dependent neuroprotective protein Mus musculus 31-35 14526315-14 2003 CONCLUSION: Alcohol increased embryonic and decidual ADNP expression at 24 hours and it persisted in the embryo for 10 days. Alcohols 12-19 activity-dependent neuroprotective protein Mus musculus 53-57