PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15770102-0 2005 Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol. Alcohols 130-137 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 16-41 20496163-2 2010 A site of action for both nicotine and alcohol effects in the brain are neuronal nicotinic acetylcholine receptors (nAChR). Alcohols 39-46 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 81-114 20496163-2 2010 A site of action for both nicotine and alcohol effects in the brain are neuronal nicotinic acetylcholine receptors (nAChR). Alcohols 39-46 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 116-121 20496163-3 2010 This report explores the association between six nAChR subunit genes (Chrna3, Chrna4, Chrnb4, Chrnb2, Chrna5, and Chrna7) with alcohol preference (AP) using co-segregation of AP with nAChR subunit genotypes in a F(2) population produced from reciprocal crosses of alcohol-preferring C57BL/6J (B6) and alcohol-avoiding DBA/2J (D2) strains of mice. Alcohols 127-134 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 49-54 20496163-3 2010 This report explores the association between six nAChR subunit genes (Chrna3, Chrna4, Chrnb4, Chrnb2, Chrna5, and Chrna7) with alcohol preference (AP) using co-segregation of AP with nAChR subunit genotypes in a F(2) population produced from reciprocal crosses of alcohol-preferring C57BL/6J (B6) and alcohol-avoiding DBA/2J (D2) strains of mice. Alcohols 127-134 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 114-120 20496163-3 2010 This report explores the association between six nAChR subunit genes (Chrna3, Chrna4, Chrnb4, Chrnb2, Chrna5, and Chrna7) with alcohol preference (AP) using co-segregation of AP with nAChR subunit genotypes in a F(2) population produced from reciprocal crosses of alcohol-preferring C57BL/6J (B6) and alcohol-avoiding DBA/2J (D2) strains of mice. Alcohols 264-271 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 49-54 20496163-3 2010 This report explores the association between six nAChR subunit genes (Chrna3, Chrna4, Chrnb4, Chrnb2, Chrna5, and Chrna7) with alcohol preference (AP) using co-segregation of AP with nAChR subunit genotypes in a F(2) population produced from reciprocal crosses of alcohol-preferring C57BL/6J (B6) and alcohol-avoiding DBA/2J (D2) strains of mice. Alcohols 264-271 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 49-54 20668200-1 2010 Recently, the smoking cessation therapeutic varenicline, a nicotinic acetylcholine receptor (nAChR) partial agonist, has been shown to reduce alcohol consumption. Alcohols 142-149 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 59-91 20668200-1 2010 Recently, the smoking cessation therapeutic varenicline, a nicotinic acetylcholine receptor (nAChR) partial agonist, has been shown to reduce alcohol consumption. Alcohols 142-149 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 93-98 20668200-4 2010 To gain insight into which nAChR subtypes may be involved in the response to alcohol, we analyzed nAChR subunit gene expression in posterior VTA DAergic neurons. Alcohols 77-84 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 27-32 19492010-5 2008 The nAChRs are important components of the dopaminergic reward system because some of the receptors have been shown to activate the release of dopamine, and mice lacking genes for specific nAChR gene subunits show altered behavioral responses to nicotine and alcohol. Alcohols 259-266 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 4-9 15770102-11 2005 CONCLUSIONS: These results indicate that some but not all of the behavioral effects of ethanol are mediated in part by effects on nAChRs that include the alpha7 subunit and may help to explain the robust association between alcohol consumption and the use of tobacco. Alcohols 224-231 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 154-160 29355641-2 2018 The nicotinic acetylcholine receptors (nAChRs) are critical for both alcohol and nicotine addiction mechanisms, since nAChR drugs that reduce nicotine consumption have been shown to also reduce alcohol consumption. Alcohols 69-76 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 39-44 29355641-2 2018 The nicotinic acetylcholine receptors (nAChRs) are critical for both alcohol and nicotine addiction mechanisms, since nAChR drugs that reduce nicotine consumption have been shown to also reduce alcohol consumption. Alcohols 194-201 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 39-44 29355641-11 2018 Collectively, these data suggest a novel role for the nAChR targets of sazetidine-A in specifically mediating alcohol consumption, separate from the involvement of nAChRs in mediating nicotine consumption. Alcohols 110-117 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 54-59 28332590-8 2017 Finally, we showed that nicotine-induced modifications of alcohol responses were absent in beta2-/- and beta4-/- mice, suggesting that nicotine triggers beta2* and beta4 * nAChR-dependent neuroadaptations that subsequently modify the responses to alcohol and thus indicating these receptors as key mediators in the complex interactions between these two drugs. Alcohols 58-65 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 172-177 28332590-8 2017 Finally, we showed that nicotine-induced modifications of alcohol responses were absent in beta2-/- and beta4-/- mice, suggesting that nicotine triggers beta2* and beta4 * nAChR-dependent neuroadaptations that subsequently modify the responses to alcohol and thus indicating these receptors as key mediators in the complex interactions between these two drugs. Alcohols 247-254 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 172-177 23872372-2 2013 Pre-clinical and clinical studies have shown that neuronal nicotinic acetylcholine receptor (nAChR) partial agonists such as cytisine and its derivative, varenicline, reduce alcohol (ethanol) consumption and seeking behavior. Alcohols 174-181 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 59-91 23872372-2 2013 Pre-clinical and clinical studies have shown that neuronal nicotinic acetylcholine receptor (nAChR) partial agonists such as cytisine and its derivative, varenicline, reduce alcohol (ethanol) consumption and seeking behavior. Alcohols 174-181 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 93-98