PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15686933-0	2005	De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold.	Hydantoins	94-103	integrin subunit alpha L	Homo sapiens	52-57	
15686933-4	2005	This paper describes the de novo design, synthesis and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold.	Hydantoins	118-127	integrin subunit alpha L	Homo sapiens	76-81	
20405922-4	2010	This article will detail the structure-activity relationships (SAR) leading to a novel second generation series of highly potent spirocyclic hydantoin antagonists of LFA-1.	Hydantoins	141-150	integrin subunit alpha L	Homo sapiens	166-171	
11403595-0	2001	Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction.	Hydantoins	28-37	integrin subunit alpha L	Homo sapiens	59-64	
11403595-1	2001	The binding site on the lymphocyte function-associated antigen-1 (LFA-1) of a class of hydantoin-based antagonists of leukocyte cell adhesion has been identified.	Hydantoins	87-96	integrin subunit alpha L	Homo sapiens	24-64	
11403595-1	2001	The binding site on the lymphocyte function-associated antigen-1 (LFA-1) of a class of hydantoin-based antagonists of leukocyte cell adhesion has been identified.	Hydantoins	87-96	integrin subunit alpha L	Homo sapiens	66-71	
12504329-2	2003	Binding of hydantoins to the I domain of LFA-1 is observed by size exclusion chromatography/mass spectrometry (SEC/MS) and by direct electrospray ionization mass spectrometry (ESI/MS).	Hydantoins	11-21	integrin subunit alpha L	Homo sapiens	41-46	
12504329-3	2003	A photoactive hydantoin analog specifically labels an amino acid residue of LFA-1 I domain.	Hydantoins	14-23	integrin subunit alpha L	Homo sapiens	76-81	
12504329-6	2003	The results demonstrate specific, stoichiometric, reversible binding of the hydantoins to LFA-1.	Hydantoins	76-86	integrin subunit alpha L	Homo sapiens	90-95	
17125246-2	2006	This letter describes the discovery and preliminary SAR of spirocyclic hydantoin based LFA-1 antagonists that culminated in the identification of analog 8 as a clinical candidate.	Hydantoins	71-80	integrin subunit alpha L	Homo sapiens	87-92