PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26963243-7 2016 Docking complexes of the nine phthalates displayed interactions with 15-31 amino acid residues of SHBG and a commonality of 55-95% interacting residues between natural ligand of SHBG, dihydrotestosterone, and the nine phthalate compounds was observed. phthalic acid 30-39 sex hormone binding globulin Homo sapiens 98-102 35114227-7 2022 RESULTS: The linear regression showed that 2 phenols, 2 parabens, and 3 phthalate metabolites were generally negatively associated with E2, TT, FAI, and TT/E2, while positively with SHBG. phthalic acid 72-81 sex hormone binding globulin Homo sapiens 182-186 35114227-10 2022 CONCLUSIONS: Exposure to phenols, parabens, and phthalates, either individuals or as a mixture, was negatively associated with E2, TT, FAI and TT/E2, while positively with SHBG. phthalic acid 48-58 sex hormone binding globulin Homo sapiens 172-176 26963243-7 2016 Docking complexes of the nine phthalates displayed interactions with 15-31 amino acid residues of SHBG and a commonality of 55-95% interacting residues between natural ligand of SHBG, dihydrotestosterone, and the nine phthalate compounds was observed. phthalic acid 30-39 sex hormone binding globulin Homo sapiens 178-182 26963243-10 2016 Hence, overlapping of interacting amino acid residues between phthalate compounds and natural ligand, dihydrotestosterone, suggested potential disrupting activity of phthalates in the endocrine homeostasis function of SHBG, with long chain phthalates expected to be more potent than the short chain phthalates. phthalic acid 62-71 sex hormone binding globulin Homo sapiens 218-222