PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23545481-6	2013	Estimated CLint for phthalic acid production by hCYP3A4 was 24.5 muL nmol CYP(-1)min(-1) while it was continuously produced by rCYP2C6 and 3A2 via passive mechanism.	phthalic acid	20-33	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	48-55	
27572875-4	2016	PXR agonists, phthalate and pregnenolone had significant positive effects on cytochrome P450 (CYP) 3A4 expression and PXR-mediated transcription through the CYP3A4 promoter, whereas MDR1 expression and PXR-mediated transcription though the MDR1 promoter were significantly increased in the presence of paclitaxel or cisplatin.	phthalic acid	14-23	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	157-163	
22186153-6	2012	Additionally, human CYP3A4 and rat CYP3A2 were the primary enzymes for PA production via heteroatom dealkylation of MEHP.	phthalic acid	71-73	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	20-26	
18332045-0	2008	Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression.	phthalic acid	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	23-29	
18332045-6	2008	We suggest that the magnitude of CYP3A4 induction by phthalates is dependent on the expression of PXR and may be significantly higher in the presence of glucocorticoids.	phthalic acid	53-63	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	33-39	
18332045-8	2008	Coexposure to phthalates and dexamethasone (Dex) resulted in enhanced CYP3A4 promoter activity; furthermore, this induction was abrogated by both the GR antagonist RU486 and GR small interfering ribonucleic acid.	phthalic acid	14-24	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	70-76	
18332045-11	2008	Finally, enhanced 6beta-hydroxytestosterone formation in Dex and phthalate cotreated human hepatocytes confirmed CYP3A4 enzyme induction.	phthalic acid	65-74	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	113-119	
18332045-12	2008	Concomitant exposure to glucocorticoids and phthalates resulting in enhanced metabolic activity of CYP3A4 may play a role in altered efficacy of pharmaceutical agents.	phthalic acid	44-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	99-105