PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22472124-1	2012	BACKGROUND: Phthalates, commonly used to soften plastic goods, are known PPAR-agonists affecting lipid metabolism and adipocytes in the experimental setting.	phthalic acid	12-22	peroxisome proliferator activated receptor alpha	Homo sapiens	73-77	
18288285-6	2008	Here, we analyze the epidemiological and experimental evidence linking phthalate exposure to both PPAR activation and adverse effects on male and female reproductive health.	phthalic acid	71-80	peroxisome proliferator activated receptor alpha	Homo sapiens	98-102	
15521013-5	2004	RESULTS: We show that peroxisome proliferator-activated receptor-alpha agonists (WY-14643, bezafibrate, clofibrate, and phthalate) induce human cytochrome P450 1A1 gene expression, whereas 2,4-thiazolidinedione, a specific peroxisome proliferator-activated receptor-gamma agonist, represses it.	phthalic acid	120-129	peroxisome proliferator activated receptor alpha	Homo sapiens	22-70	
15310864-7	2004	These studies show that the potency and efficacy of phthalate monoesters for the activation of PPARalpha and PPARgamma increase with increasing side-chain length.	phthalic acid	52-61	peroxisome proliferator activated receptor alpha	Homo sapiens	95-104	
12805656-0	2003	Activation of PPARalpha and PPARgamma by environmental phthalate monoesters.	phthalic acid	55-64	peroxisome proliferator activated receptor alpha	Homo sapiens	14-23	
12805656-4	2003	Human exposure to other phthalate monoesters, including metabolites of di-n-butyl phthalate and butyl benzyl phthalate, is substantially higher than that of MEHP, prompting this investigation of their potential for PPAR activation, assayed in COS cells and in PPAR-responsive liver (PPARalpha) and adipocyte (PPARgamma) cell lines.	phthalic acid	24-33	peroxisome proliferator activated receptor alpha	Homo sapiens	215-219	
34484127-10	2021	Exposure of human cell lines to MP additives such as phthalates, bisphenols, and organotins causes adverse effects through the activation of nuclear receptors, peroxisome proliferator-activated receptors (PPARs) alpha, beta, and gamma, and retinoid X receptor (RXR), leading to oxidative stress, cytotoxicity, immunotoxicity, thyroid hormone disruption, and altered adipogenesis and energy production.	phthalic acid	53-63	peroxisome proliferator activated receptor alpha	Homo sapiens	160-234	
31146096-6	2019	The activation of several receptors, such as PPARalpha, PPARgamma, and GR, may initiate events leading to impaired male and female fertility as well as other adverse effects of phthalate exposure.	phthalic acid	177-186	peroxisome proliferator activated receptor alpha	Homo sapiens	45-54	
17017909-6	2006	Phthalates induce and activate a subset of peroxisome proliferator-activated receptors (PPARs) and have an intrinsic pro-inflammatory activity, while some natural PPAR agonists induce cyclooxygenase (COX)-2 expression.	phthalic acid	0-10	peroxisome proliferator activated receptor alpha	Homo sapiens	88-92	
15590130-0	2005	Role of PPARalpha in mediating the effects of phthalates and metabolites in the liver.	phthalic acid	46-56	peroxisome proliferator activated receptor alpha	Homo sapiens	8-17	
35464856-1	2022	Background: The PPARalpha gene may be crucial to the neurotoxic effect of phthalates.	phthalic acid	74-84	peroxisome proliferator activated receptor alpha	Homo sapiens	16-25	
29513082-6	2018	Findings revealed decreases in methylation of LINE-1, IGF2, and PPARA with increasing phthalate concentrations.	phthalic acid	86-95	peroxisome proliferator activated receptor alpha	Homo sapiens	64-69