PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15310864-6 2004 A number of phthalate monoesters activated both mouse and human PPARgamma, with similar sensitivity being exhibited by both receptors. phthalic acid 12-21 peroxisome proliferator activated receptor gamma Homo sapiens 64-73 17657605-4 2007 Recent studies have proposed a first set of candidate obesogens (diethylstilbestrol, bisphenol A, phthalates and organotins among others) that target nuclear hormone receptor signaling pathways (sex steroid, RXR-PPARgamma and GR) with relevance to adipocyte biology and the developmental origins of health and disease (DOHaD). phthalic acid 98-108 peroxisome proliferator activated receptor gamma Homo sapiens 212-221 15521013-5 2004 RESULTS: We show that peroxisome proliferator-activated receptor-alpha agonists (WY-14643, bezafibrate, clofibrate, and phthalate) induce human cytochrome P450 1A1 gene expression, whereas 2,4-thiazolidinedione, a specific peroxisome proliferator-activated receptor-gamma agonist, represses it. phthalic acid 120-129 peroxisome proliferator activated receptor gamma Homo sapiens 223-271 16918238-0 2006 Computational screening of phthalate monoesters for binding to PPARgamma. phthalic acid 27-36 peroxisome proliferator activated receptor gamma Homo sapiens 63-72 15310864-7 2004 These studies show that the potency and efficacy of phthalate monoesters for the activation of PPARalpha and PPARgamma increase with increasing side-chain length. phthalic acid 52-61 peroxisome proliferator activated receptor gamma Homo sapiens 109-118 15310864-8 2004 These studies also show that mouse PPARalpha and PPARbeta are generally activated at lower concentrations of phthalate monoesters than human PPARalpha and PPARbeta, and that both mouse and human PPARgamma exhibit similar sensitivity to phthalate monoesters. phthalic acid 236-245 peroxisome proliferator activated receptor gamma Homo sapiens 195-204 31146096-6 2019 The activation of several receptors, such as PPARalpha, PPARgamma, and GR, may initiate events leading to impaired male and female fertility as well as other adverse effects of phthalate exposure. phthalic acid 177-186 peroxisome proliferator activated receptor gamma Homo sapiens 56-65 12805656-0 2003 Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. phthalic acid 55-64 peroxisome proliferator activated receptor gamma Homo sapiens 28-37 34843233-8 2021 Among environmental compounds, several molecules activated the PPARgamma of the four species similarly, e.g., phthalates (MEHP), perfluorinated compounds (PFOA, PFOS), and halogenated derivatives of BPA (TBBPA, TCBPA), but some of them like diclofenac and the organophosphorus compounds tri-o-tolyl phosphate and triphenyl phosphate were most active on zfPPARgamma. phthalic acid 110-120 peroxisome proliferator activated receptor gamma Homo sapiens 63-72 35455039-8 2022 In conclusion, PPARgamma signaling is dysregulated by MEHP; this paves the way for future explorations to highlight the hypothesis of phthalates as an amniotic PPARgamma disruptor that can explain the premature rupture of FMs. phthalic acid 134-144 peroxisome proliferator activated receptor gamma Homo sapiens 15-24 35455039-8 2022 In conclusion, PPARgamma signaling is dysregulated by MEHP; this paves the way for future explorations to highlight the hypothesis of phthalates as an amniotic PPARgamma disruptor that can explain the premature rupture of FMs. phthalic acid 134-144 peroxisome proliferator activated receptor gamma Homo sapiens 160-169 32770630-6 2020 Both, BPA and phthalates, are endocrine-disruptor compounds (EDCs) with steroidogenic activity, and can bind to different receptors, such as estrogen, androgen, PPAR-gamma, and AhR. phthalic acid 14-24 peroxisome proliferator activated receptor gamma Homo sapiens 161-171 29061543-0 2018 Peroxisome proliferator activated receptor gamma in human placenta may mediate the adverse effects of phthalates exposure in pregnancy. phthalic acid 102-112 peroxisome proliferator activated receptor gamma Homo sapiens 0-48 29061543-7 2018 Phthalate levels in cord blood were positively associated with PPARG protein expression in placenta (p<0.05), whereas estrogens in cord blood were negatively associated with phthalate levels and PPARG expression (p<0.05). phthalic acid 0-9 peroxisome proliferator activated receptor gamma Homo sapiens 63-68 29061543-8 2018 This study shows that PPARG in placenta may mediate the adverse effects of phthalates on pregnancy in human. phthalic acid 75-85 peroxisome proliferator activated receptor gamma Homo sapiens 22-27 26106289-12 2015 Almost all zfPPARgamma environmental ligands (halogenated bisphenol A derivatives, phthalates, perfluorinated compounds) displayed similar affinity for human and zebrafish PPARgamma while pharmaceutical hPPARgamma agonists like thiazolidones are not recognized by zfPPARgamma. phthalic acid 83-93 peroxisome proliferator activated receptor gamma Homo sapiens 13-22 29089286-10 2017 There was evidence of agonism in female cells and antagonism in male cells of PPARgamma by simultaneous exposure to multiple phthalates. phthalic acid 125-135 peroxisome proliferator activated receptor gamma Homo sapiens 78-87 20453712-3 2010 Phthalates inactivate peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a nuclear transcription factor that mediates the resolution of inflammation, a process impaired in neonates. phthalic acid 0-10 peroxisome proliferator activated receptor gamma Homo sapiens 22-70 23866026-0 2013 PPARgamma and PPARGC1B polymorphisms modify the association between phthalate metabolites and breast cancer risk. phthalic acid 68-77 peroxisome proliferator activated receptor gamma Homo sapiens 0-9 23866026-4 2013 Phthalate metabolites were determined by HPLC-MS. PPARgamma Pro12Ala (rs1801281) and PPARGC1B Ala203Pro (rs7732671) and Val279Ile (rs17572019) were genotyped. phthalic acid 0-9 peroxisome proliferator activated receptor gamma Homo sapiens 50-59 23866026-7 2013 CONCLUSION: PPARgamma and PPARGC1B polymorphisms modulate the association between phthalate exposure and BC risk. phthalic acid 82-91 peroxisome proliferator activated receptor gamma Homo sapiens 12-21 20453712-3 2010 Phthalates inactivate peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a nuclear transcription factor that mediates the resolution of inflammation, a process impaired in neonates. phthalic acid 0-10 peroxisome proliferator activated receptor gamma Homo sapiens 72-82 20453712-11 2010 These findings suggest that neonatal neutrophils are more sensitive to phthalate-mediated inhibition of PPAR-gamma, which may be related to decreased anti-inflammatory signaling. phthalic acid 71-80 peroxisome proliferator activated receptor gamma Homo sapiens 104-114