PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30898641-4 2019 Herein, we utilize a surfactant-like chemotherapeutic agent, mitoxantrone (MTX), as a nanocarrier to deliver a photosensitizer pyropheophorbide a (PPa) for antitumor therapy. Mitoxantrone 61-73 preproenkephalin Mus musculus 147-150 30898641-4 2019 Herein, we utilize a surfactant-like chemotherapeutic agent, mitoxantrone (MTX), as a nanocarrier to deliver a photosensitizer pyropheophorbide a (PPa) for antitumor therapy. Mitoxantrone 75-78 preproenkephalin Mus musculus 147-150 30898641-5 2019 MTX consists of aromatic rings (hydrophobic part) and two amino-groups and two hydroxyl-groups (hydrophilic part) with planar structure, which could interact with PPa via pi-pi stacking, hydrophobic interactions, intermolecular hydrogen bonding and electrostatic interactions. Mitoxantrone 0-3 preproenkephalin Mus musculus 163-166 30898641-6 2019 This system (PPa@MTX) spontaneously forms near-spherical nanostructures (~150 nm), has a high loading capacity for PPa (56.5%) and exhibits a pH-responsive drug release manner in vitro. Mitoxantrone 17-20 preproenkephalin Mus musculus 13-16 30898641-6 2019 This system (PPa@MTX) spontaneously forms near-spherical nanostructures (~150 nm), has a high loading capacity for PPa (56.5%) and exhibits a pH-responsive drug release manner in vitro. Mitoxantrone 17-20 preproenkephalin Mus musculus 115-118 30898641-7 2019 In vivo antitumor efficacy evaluations show that the pegylated PPa@MTX nanosystem has increased accumulation in tumor tissues and enhanced antitumor efficacy in female BALB/c mice bearing murine mammary carcinoma (4T1) tumor cells, compared to free PPa. Mitoxantrone 67-70 preproenkephalin Mus musculus 63-66 30898641-7 2019 In vivo antitumor efficacy evaluations show that the pegylated PPa@MTX nanosystem has increased accumulation in tumor tissues and enhanced antitumor efficacy in female BALB/c mice bearing murine mammary carcinoma (4T1) tumor cells, compared to free PPa. Mitoxantrone 67-70 preproenkephalin Mus musculus 249-252