PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32656158-4	2020	To specifically and quickly measure CYP3A activity, we developed method based on gas chromatography interfaced with triple-quadrupole mass spectrometry for the quantification of cortisol, cortisone, 6beta-hydroxycortisol, and 6beta-hydroxycortisone simultaneously in urine and 4beta-hydroxycholesterol in plasma.	6 beta-hydroxycortisone	226-248	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	36-41	
26924289-3	2016	The endogenous CYP3A4 phenotype was assessed by the ratio of 6beta-hydroxycortisol and 6beta-hydroxycortisone to cortisol and cortisone in urine.	6 beta-hydroxycortisone	87-109	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	15-21	
26150050-0	2015	Evaluation of 6beta-Hydroxycortisol and 6beta-Hydroxycortisone as Biomarkers for Cytochrome P450 3A Activity: Insight into Their Predictive Value for Estimating Oral Immunosuppressant Metabolism.	6 beta-hydroxycortisone	40-62	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	81-99	
26150050-1	2015	The combined clearance of endogenous 6beta-hydroxycortisol and 6beta-hydroxycortisone is suggested biomarker for in vivo cytochrome P450 3A (CYP3A) activity.	6 beta-hydroxycortisone	63-85	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	121-139	
26150050-1	2015	The combined clearance of endogenous 6beta-hydroxycortisol and 6beta-hydroxycortisone is suggested biomarker for in vivo cytochrome P450 3A (CYP3A) activity.	6 beta-hydroxycortisone	63-85	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	141-146	
21490593-2	2011	The aim of this study was to determine whether formation clearance (CL(f)) of the sum of 6beta-hydroxycortisol and 6beta-hydroxycortisone is a useful probe of CYP3A4 inhibition in vivo.	6 beta-hydroxycortisone	115-137	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	159-165	
21490593-3	2011	In human liver microsomes (HLMs), the formation of 6beta-hydroxycortisol and 6beta-hydroxycortisone was catalyzed by CYP3A4, and itraconazole inhibited these reactions with half maximal inhibitory concentration (IC(50))(,u) values of 3.1 nmol/l and 3.4 nmol/l, respectively.	6 beta-hydroxycortisone	77-99	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	117-123	
31721244-3	2020	METHODS: A random forest (RF) algorithm which incorporated an endogenous CYP3A4 phenotype (assessed by urinary ratio of 6beta-hydroxycortisol and 6beta-hydroxycortisone to cortisol and cortisone), CYP3A5*3 genotype and other clinical determinants of tacrolimus disposition was performed in 182 medically stable renal transplant recipients.	6 beta-hydroxycortisone	146-168	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	73-79