PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31945545-0 2020 MOP-dependent enhancement of methadone on the effectiveness of ALA-PDT for A172 cells by upregulating phosphorylated JNK and BCL2. 1-phenyl-3,3-dimethyltriazene 63-70 mitogen-activated protein kinase 8 Homo sapiens 117-120 31945545-7 2020 Phosphorylated JNK and BCL2 induced by ALA-PDT were promoted in the presence of methadone (p < 0.05). 1-phenyl-3,3-dimethyltriazene 39-46 mitogen-activated protein kinase 8 Homo sapiens 15-18 31945545-9 2020 CONCLUSIONS: The results suggest that apoptosis induced by ALA-PDT is enhanced by methadone, mostly MOP-mediated, through the upregulation of accumulation of phosphorylated JNK and BCL2, leading to a promotion of cytotoxicity of ALA-PDT for A172 cells. 1-phenyl-3,3-dimethyltriazene 59-66 mitogen-activated protein kinase 8 Homo sapiens 173-176 31945545-9 2020 CONCLUSIONS: The results suggest that apoptosis induced by ALA-PDT is enhanced by methadone, mostly MOP-mediated, through the upregulation of accumulation of phosphorylated JNK and BCL2, leading to a promotion of cytotoxicity of ALA-PDT for A172 cells. 1-phenyl-3,3-dimethyltriazene 229-236 mitogen-activated protein kinase 8 Homo sapiens 173-176