PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31500290-5 2019 We determined that the HDAC1/2/3 inhibitor Mocetinostat synergizes with the HDAC4/5/6 inhibitor LMK-235 in a panel of PDAC cell lines. mocetinostat 43-55 histone deacetylase 1 Homo sapiens 23-32 18413790-4 2008 We have developed an isotype-selective HDAC inhibitor, MGCD0103, which potently targets human HDAC1 but also has inhibitory activity against HDAC2, HDAC3, and HDAC11 in vitro. mocetinostat 55-63 histone deacetylase 1 Homo sapiens 94-99 22818799-3 2012 More complex second generation HDACIs undergoing clinical trials, such as the benzamide group compounds MS-275 and MGCD0103, are specific primarily for HDAC1 and HDAC2. mocetinostat 115-123 histone deacetylase 1 Homo sapiens 152-157 25341045-4 2014 Further, knockdown of HDAC1 in leukemia cells K562, HL-60, and U937 significantly increased Klf4 expression and inhibited cell cycle progression and cell proliferation, similar results were found for HDAC inhibitors (VPA and mocetinostat). mocetinostat 225-237 histone deacetylase 1 Homo sapiens 22-27 17868033-6 2008 MS-275 was HDAC1-selective, MGCD0103 was HDAC1- and HDAC2-selective, apicidin was HDAC2- and HDAC3-selective and valproic acid was a specific inhibitor of class I HDACs. mocetinostat 28-36 histone deacetylase 1 Homo sapiens 41-46 17455259-4 2007 In contrast, the benzamides CI994, MS275 and MGCD0103 are more selective, potent inhibitors of at least HDAC1 and HDAC3. mocetinostat 45-53 histone deacetylase 1 Homo sapiens 104-109