PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28386349-5	2017	In contrast, osteoclast surface and ratio of RANKL and OPG mRNA relative expression levels were increased significantly in ORX mice compared with shame mice, but were decreased significantly by PQQ supplementation.	PQQ Cofactor	194-197	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	45-50	
23613773-1	2013	The effects of pyrroloquinoline quinine (PQQ) on RANKL-induced osteoclast differentiation and on wear particle-induced osteolysis were examined in this study.	PQQ Cofactor	41-44	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	49-54	
23613773-2	2013	PQQ inhibited RANKL-mediated osteoclast differentiation in bone marrow macrophages (BMMs) in a dose-dependent manner without any evidence of cytotoxicity.	PQQ Cofactor	0-3	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	14-19	
23613773-3	2013	The mRNA expression of c-Fos, NFATc1, and TRAP in RANKL-treated BMMs was inhibited by PQQ treatment.	PQQ Cofactor	86-89	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	50-55	
23613773-4	2013	Moreover, RANKL-induced c-Fos and NFATc1 protein expression was suppressed by PQQ.	PQQ Cofactor	78-81	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	10-15	
22193059-0	2012	Inhibition of receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast formation by pyrroloquinoline quinine (PQQ).	PQQ Cofactor	131-134	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	66-71	
22193059-1	2012	The effect of pyrroloquinoline quinine (PQQ) on receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast formation was examined using RAW 264.7 macrophage-like cells.	PQQ Cofactor	40-43	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	100-105	
22193059-3	2012	However, PQQ inhibited the appearance of osteoclasts and prevented the decrease of F4/80 macrophage maturation marker on RANKL-stimulated cells, suggesting a preventive action of PQQ on RANKL-induced osteoclast differentiation.	PQQ Cofactor	9-12	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	121-126	
22193059-3	2012	However, PQQ inhibited the appearance of osteoclasts and prevented the decrease of F4/80 macrophage maturation marker on RANKL-stimulated cells, suggesting a preventive action of PQQ on RANKL-induced osteoclast differentiation.	PQQ Cofactor	9-12	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	186-191	
22193059-3	2012	However, PQQ inhibited the appearance of osteoclasts and prevented the decrease of F4/80 macrophage maturation marker on RANKL-stimulated cells, suggesting a preventive action of PQQ on RANKL-induced osteoclast differentiation.	PQQ Cofactor	179-182	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	186-191	
22193059-4	2012	PQQ inhibited the activation of nuclear factor of activated T cells (NFATc1), a key transcription factor of osteoclastogenesis, in RANKL-stimulated cells.	PQQ Cofactor	0-3	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	131-136	
22193059-8	2012	Taken together, PQQ was suggested to prevent RANKL-induced osteoclast formation via the inactivation of NFATc1 by reduced c-Fos expression.	PQQ Cofactor	16-19	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	45-50