PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33724611-9 2021 Subsequently, we found that TRIM24 negatively regulated NLRP3/Caspase-1/IL-1beta-mediated pyroptosis and cell migration of hESC, and CY-09, the specific inhibitor of NLRP3, could reverse the promoted pyroptosis and cell migration induced by siTRIM24. CY5.5 cyanine dye 133-138 NLR family pyrin domain containing 3 Homo sapiens 166-171 33765556-0 2021 CY-09 attenuates the progression of osteoarthritis via inhibiting NLRP3 inflammasome-mediated pyroptosis. CY5.5 cyanine dye 0-5 NLR family pyrin domain containing 3 Homo sapiens 66-71 33765556-3 2021 This research was conducted to confirm whether NLRP3 expression and activity are impacted in the development of OA and to detect the role of CY-09, a selective and direct inhibitor of NLRP3 in the in vitro and in vivo models of OA. CY5.5 cyanine dye 141-146 NLR family pyrin domain containing 3 Homo sapiens 184-189 33765556-5 2021 CY-09 can maintain extracellular matrix (ECM) homeostasis and regulate inflammation in TNF-alpha treated chondrocytes via inhibition of NLRP3 inflammasome-mediated pyroptosis. CY5.5 cyanine dye 0-5 NLR family pyrin domain containing 3 Homo sapiens 136-141 33765556-7 2021 In conclusion, our research indicates that experimental OA activated the NLRP3 activity, and pharmacological inhibition of NLRP3 inflammasome activation by CY-09 protects chondrocytes against inflammation and attenuates OA development. CY5.5 cyanine dye 156-161 NLR family pyrin domain containing 3 Homo sapiens 123-128 34426748-0 2021 CY-09 Inhibits NLRP3 Inflammasome Activation to Relieve Pain via TRPA1. CY5.5 cyanine dye 0-5 NLR family pyrin domain containing 3 Homo sapiens 15-20 34426748-8 2021 Our findings indicate that CY-09 relieves inflammation and pain via inhibiting TRPA1-mediated activation of NLRP3 inflammasomes. CY5.5 cyanine dye 27-32 NLR family pyrin domain containing 3 Homo sapiens 108-113 34393801-7 2021 Western blot was performed to evaluate the expression of NLRP3 and the related proteins in osteosarcoma cell lines after the blockade of NLRP3 using CY-09 and lentivirus intervention. CY5.5 cyanine dye 149-154 NLR family pyrin domain containing 3 Homo sapiens 57-62 34393801-7 2021 Western blot was performed to evaluate the expression of NLRP3 and the related proteins in osteosarcoma cell lines after the blockade of NLRP3 using CY-09 and lentivirus intervention. CY5.5 cyanine dye 149-154 NLR family pyrin domain containing 3 Homo sapiens 137-142 34393801-10 2021 Moreover, NLRP3 suppression by the inhibitor of CY-09 or lentivirus-induced gene knockdown inhibited the cell proliferation, migration, invasion and promoted the cell apoptosis and G1 cell cycle arrest in osteosarcoma via targeting the inflammasome pathway. CY5.5 cyanine dye 48-53 NLR family pyrin domain containing 3 Homo sapiens 10-15 32578856-15 2020 CONCLUSION: NLRP3 could enhance resistance to gemcitabine via IL-1beta/EMT/Wnt/beta-catenin signaling, which suggested that NLRP3 antagonist CY-09 might be incorporated into gemcitabine treatment for TNBC. CY5.5 cyanine dye 141-146 NLR family pyrin domain containing 3 Homo sapiens 12-17 32578856-15 2020 CONCLUSION: NLRP3 could enhance resistance to gemcitabine via IL-1beta/EMT/Wnt/beta-catenin signaling, which suggested that NLRP3 antagonist CY-09 might be incorporated into gemcitabine treatment for TNBC. CY5.5 cyanine dye 141-146 NLR family pyrin domain containing 3 Homo sapiens 124-129 29794149-6 2018 Using the direct NLRP3 inhibitor, CY-09, we demonstrated significantly reduced human platelet aggregation in response to threshold concentrations of collagen and ADP, as well as impaired clot retraction in CY-09-treated human platelets, supporting a role for NLRP3 also in regulating human platelet alphaIIbbeta3 outside-in signaling. CY5.5 cyanine dye 34-39 NLR family pyrin domain containing 3 Homo sapiens 17-22 29794149-6 2018 Using the direct NLRP3 inhibitor, CY-09, we demonstrated significantly reduced human platelet aggregation in response to threshold concentrations of collagen and ADP, as well as impaired clot retraction in CY-09-treated human platelets, supporting a role for NLRP3 also in regulating human platelet alphaIIbbeta3 outside-in signaling. CY5.5 cyanine dye 34-39 NLR family pyrin domain containing 3 Homo sapiens 259-264 29794149-6 2018 Using the direct NLRP3 inhibitor, CY-09, we demonstrated significantly reduced human platelet aggregation in response to threshold concentrations of collagen and ADP, as well as impaired clot retraction in CY-09-treated human platelets, supporting a role for NLRP3 also in regulating human platelet alphaIIbbeta3 outside-in signaling. CY5.5 cyanine dye 206-211 NLR family pyrin domain containing 3 Homo sapiens 17-22 29021150-3 2017 Here we show that the compound CY-09 specifically blocks NLRP3 inflammasome activation. CY5.5 cyanine dye 31-36 NLR family pyrin domain containing 3 Homo sapiens 57-62 29021150-4 2017 CY-09 directly binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity, resulting in the suppression of NLRP3 inflammasome assembly and activation. CY5.5 cyanine dye 0-5 NLR family pyrin domain containing 3 Homo sapiens 49-54 29021150-4 2017 CY-09 directly binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity, resulting in the suppression of NLRP3 inflammasome assembly and activation. CY5.5 cyanine dye 0-5 NLR family pyrin domain containing 3 Homo sapiens 81-86 29021150-4 2017 CY-09 directly binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity, resulting in the suppression of NLRP3 inflammasome assembly and activation. CY5.5 cyanine dye 0-5 NLR family pyrin domain containing 3 Homo sapiens 81-86