PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11723116-5	2002	The data show that in human smooth muscle cells, activation of PKG by 8-Br-cGMP led to phosphorylation and activation of PDE5.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	70-79	phosphodiesterase 5A	Homo sapiens	121-125	
20698857-7	2010	The ligand for the GAF domains of PDE5, 8-Br-cGMP, elicited a 20-fold GAF-dependent activation and moreover revealed a time-dependent increase in PDE5 activity that occurred independently of a GAF ligand.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	40-49	phosphodiesterase 5A	Homo sapiens	34-38	
20698857-7	2010	The ligand for the GAF domains of PDE5, 8-Br-cGMP, elicited a 20-fold GAF-dependent activation and moreover revealed a time-dependent increase in PDE5 activity that occurred independently of a GAF ligand.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	40-49	phosphodiesterase 5A	Homo sapiens	146-150	
31434939-7	2019	VSMC stimulation with GSNO, a nitric oxide analogue or with 8-br-cGMP, but not with 8-br-cAMP, up-regulated PDE5 and NOTCH-3 protein levels, indicating a negative feedback loop to protect the arterial wall from excessive relaxation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	60-69	phosphodiesterase 5A	Homo sapiens	108-112