PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24989004-0 2014 Changes in PtdIns(4,5)P2 induced by etoposide treatment modulates small intestinal P-glycoprotein via radixin. Phosphatidylinositol 4,5-Diphosphate 11-24 radixin Homo sapiens 102-109 25073508-2 2014 The Protein 4.1, Ezrin, radixin, moesin (FERM) domain of Ezrin binds the membrane Phosphatydil inositol (4,5) bisphosphate (PIP2), a crucial molecule belonging to the Phosphoinositide (PI) signal transduction pathway. Phosphatidylinositol 4,5-Diphosphate 124-128 radixin Homo sapiens 24-31 24989004-9 2014 In immunoprecipitation assays, radixin (but not ezrin or moesin) binding to PtdIns(4,5)P2 was observed to increase in association with the up-regulation of P-gp in the same fraction, and immunofluorescence studies indicated that radixin co-localized with PtdIns(4,5)P2 in the ileal tissue. Phosphatidylinositol 4,5-Diphosphate 76-89 radixin Homo sapiens 31-38 24989004-9 2014 In immunoprecipitation assays, radixin (but not ezrin or moesin) binding to PtdIns(4,5)P2 was observed to increase in association with the up-regulation of P-gp in the same fraction, and immunofluorescence studies indicated that radixin co-localized with PtdIns(4,5)P2 in the ileal tissue. Phosphatidylinositol 4,5-Diphosphate 76-89 radixin Homo sapiens 229-236 24989004-9 2014 In immunoprecipitation assays, radixin (but not ezrin or moesin) binding to PtdIns(4,5)P2 was observed to increase in association with the up-regulation of P-gp in the same fraction, and immunofluorescence studies indicated that radixin co-localized with PtdIns(4,5)P2 in the ileal tissue. Phosphatidylinositol 4,5-Diphosphate 255-268 radixin Homo sapiens 31-38 24989004-10 2014 In conclusion, ETP treatment appears to up-regulate PtdIns(4,5)P2 expression via RhoA/ROCK signaling, leading to the activation of ERM, presumably through the physical interaction of radixin with PtdIns(4,5)P2. Phosphatidylinositol 4,5-Diphosphate 52-65 radixin Homo sapiens 183-190 24989004-10 2014 In conclusion, ETP treatment appears to up-regulate PtdIns(4,5)P2 expression via RhoA/ROCK signaling, leading to the activation of ERM, presumably through the physical interaction of radixin with PtdIns(4,5)P2. Phosphatidylinositol 4,5-Diphosphate 196-209 radixin Homo sapiens 183-190