PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21940450-5	2011	Decreased production of DAG (an activator of PKC) by inhibition of PIP2 (phosphatidylinositol-4,5-bisphosphate) hydrolysis caused depression of the TRPM1 current.	Phosphatidylinositol 4,5-Diphosphate	67-71	protein kinase C, alpha	Mus musculus	45-48	
21940450-5	2011	Decreased production of DAG (an activator of PKC) by inhibition of PIP2 (phosphatidylinositol-4,5-bisphosphate) hydrolysis caused depression of the TRPM1 current.	Phosphatidylinositol 4,5-Diphosphate	73-110	protein kinase C, alpha	Mus musculus	45-48	
7876145-3	1995	The increase in inositol phosphates induced by bFGF, EGF, or bombesin was significantly enhanced by Ro-31-8220, an inhibitor of protein kinase C (PKC), suggesting that PtdIns(4,5)P2-hydrolyzing phospholipase is coupled to the receptors for these agonists but that the response is down-regulated by PKC.	Phosphatidylinositol 4,5-Diphosphate	168-181	protein kinase C, alpha	Mus musculus	146-149	
16962988-0	2006	Protein kinase Calpha can undergo membrane localization via an alternative phosphatidylinositol 4,5-bisphosphate-dependent pathway.	Phosphatidylinositol 4,5-Diphosphate	75-112	protein kinase C, alpha	Mus musculus	0-21	
16962988-1	2006	Protein kinase Calpha (PKCalpha) activation is known to be dependent on the metabolic product of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C (PLC).	Phosphatidylinositol 4,5-Diphosphate	97-134	protein kinase C, alpha	Mus musculus	0-21	
16962988-1	2006	Protein kinase Calpha (PKCalpha) activation is known to be dependent on the metabolic product of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C (PLC).	Phosphatidylinositol 4,5-Diphosphate	97-134	protein kinase C, alpha	Mus musculus	23-31	
16962988-1	2006	Protein kinase Calpha (PKCalpha) activation is known to be dependent on the metabolic product of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C (PLC).	Phosphatidylinositol 4,5-Diphosphate	136-140	protein kinase C, alpha	Mus musculus	0-21	
16962988-1	2006	Protein kinase Calpha (PKCalpha) activation is known to be dependent on the metabolic product of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C (PLC).	Phosphatidylinositol 4,5-Diphosphate	136-140	protein kinase C, alpha	Mus musculus	23-31	
16962988-5	2006	PKCalpha levels in the membrane fraction decreased following incubation with PLCgamma, but increased following treatment with U73122 or addition of exogenous PIP2 in vitro.	Phosphatidylinositol 4,5-Diphosphate	158-162	protein kinase C, alpha	Mus musculus	0-8	
16962988-6	2006	In addition, PKCalpha interacted with PIP2-conjugate bead and mixed micelles containing PIP2.	Phosphatidylinositol 4,5-Diphosphate	38-42	protein kinase C, alpha	Mus musculus	13-21	
16962988-6	2006	In addition, PKCalpha interacted with PIP2-conjugate bead and mixed micelles containing PIP2.	Phosphatidylinositol 4,5-Diphosphate	88-92	protein kinase C, alpha	Mus musculus	13-21	
16962988-7	2006	Finally, we found that PIP2 is involved in syndecan-4-mediated membrane localization of PKCalpha.	Phosphatidylinositol 4,5-Diphosphate	23-27	protein kinase C, alpha	Mus musculus	88-96	
16962988-8	2006	Taken together, these data suggest that PIP2 might contribute to directly regulating the membrane localization of PKCalpha.	Phosphatidylinositol 4,5-Diphosphate	40-44	protein kinase C, alpha	Mus musculus	114-122	
12543640-2	2003	Unlike other members of syndecan family, syndecan-4 mediates phosphatidylinositol 4,5-bisphosphate 2 (PIP(2))-dependent PKC-alpha activation, and overexpression of syndecan-4 in vitro results in enhanced FGF2 signaling.	Phosphatidylinositol 4,5-Diphosphate	61-98	protein kinase C, alpha	Mus musculus	120-129	
12543640-2	2003	Unlike other members of syndecan family, syndecan-4 mediates phosphatidylinositol 4,5-bisphosphate 2 (PIP(2))-dependent PKC-alpha activation, and overexpression of syndecan-4 in vitro results in enhanced FGF2 signaling.	Phosphatidylinositol 4,5-Diphosphate	102-109	protein kinase C, alpha	Mus musculus	120-129	
7876145-3	1995	The increase in inositol phosphates induced by bFGF, EGF, or bombesin was significantly enhanced by Ro-31-8220, an inhibitor of protein kinase C (PKC), suggesting that PtdIns(4,5)P2-hydrolyzing phospholipase is coupled to the receptors for these agonists but that the response is down-regulated by PKC.	Phosphatidylinositol 4,5-Diphosphate	168-181	protein kinase C, alpha	Mus musculus	298-301