PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33103897-5 2020 Using phenethylamine (PA) as a specific substrate of MAOB, the enzyme product phenylacetaldehyde (PAA) will produce significant Raman signals via the amine-aldehyde click reaction with CA, while other molecules, such as MAOB and PA, have no signal output because they cannot form close interaction with nanoparticles due to the existence of a CA layer. phenethylamine 6-20 monoamine oxidase B Homo sapiens 53-57 3118881-0 1987 [13N]-beta-phenethylamine ([13N]PEA): a prototype tracer for measurement of MAO-B activity in heart. phenethylamine 6-25 monoamine oxidase B Homo sapiens 76-81 3116977-7 1987 Significantly lower MAO B activities were observed in hypertensive patients both in men (19.25 +/- 2.20, n = 8 versus 24.35 +/- 2.22, n = 14, desaminated beta-phenyl-ethylamine/10(9) platelets/hour, x +/- SEM, p less than 0.05) and in women (23.92 +/- 2.74, n = 10 versus 35.76 +/- 2.35, n = 21, p less than 0.01) when compared to normotensive controls of the same sex. phenethylamine 154-176 monoamine oxidase B Homo sapiens 20-25 3928010-2 1985 Both selective MAO-A and MAO-B inhibitors markedly potentiated nictitating membrane contractions in response to beta-phenylethylamine (PEA). phenethylamine 112-133 monoamine oxidase B Homo sapiens 25-30 3928010-2 1985 Both selective MAO-A and MAO-B inhibitors markedly potentiated nictitating membrane contractions in response to beta-phenylethylamine (PEA). phenethylamine 135-138 monoamine oxidase B Homo sapiens 25-30 3833630-3 1985 On the other hand, beta-phenylethylamine, a specific substrate for MAO B used as a substrate, showed no significant difference between the alcoholic and control groups in the activities. phenethylamine 19-40 monoamine oxidase B Homo sapiens 67-72 7422056-2 1980 It was found that the concentration of monoamine oxidase-B determined in this way was the same when either benzylamine or beta-phenethylamine was used to assay for activity, which would indicate that this enzyme form is not heterogeneous. phenethylamine 122-141 monoamine oxidase B Homo sapiens 39-58 745019-1 1978 Deprenyl is an inhibitor of monoamine oxidase type B, the enzyme responsible for 2-phenylethylamine oxidation, and is used in conjunction with L-Dopa therapy in Parkinson"s disease. phenethylamine 81-99 monoamine oxidase B Homo sapiens 28-52 33103897-5 2020 Using phenethylamine (PA) as a specific substrate of MAOB, the enzyme product phenylacetaldehyde (PAA) will produce significant Raman signals via the amine-aldehyde click reaction with CA, while other molecules, such as MAOB and PA, have no signal output because they cannot form close interaction with nanoparticles due to the existence of a CA layer. phenethylamine 6-20 monoamine oxidase B Homo sapiens 220-224 33103897-5 2020 Using phenethylamine (PA) as a specific substrate of MAOB, the enzyme product phenylacetaldehyde (PAA) will produce significant Raman signals via the amine-aldehyde click reaction with CA, while other molecules, such as MAOB and PA, have no signal output because they cannot form close interaction with nanoparticles due to the existence of a CA layer. phenethylamine 22-24 monoamine oxidase B Homo sapiens 53-57 33103897-5 2020 Using phenethylamine (PA) as a specific substrate of MAOB, the enzyme product phenylacetaldehyde (PAA) will produce significant Raman signals via the amine-aldehyde click reaction with CA, while other molecules, such as MAOB and PA, have no signal output because they cannot form close interaction with nanoparticles due to the existence of a CA layer. phenethylamine 22-24 monoamine oxidase B Homo sapiens 220-224 33103897-5 2020 Using phenethylamine (PA) as a specific substrate of MAOB, the enzyme product phenylacetaldehyde (PAA) will produce significant Raman signals via the amine-aldehyde click reaction with CA, while other molecules, such as MAOB and PA, have no signal output because they cannot form close interaction with nanoparticles due to the existence of a CA layer. phenethylamine 98-100 monoamine oxidase B Homo sapiens 53-57 33103897-5 2020 Using phenethylamine (PA) as a specific substrate of MAOB, the enzyme product phenylacetaldehyde (PAA) will produce significant Raman signals via the amine-aldehyde click reaction with CA, while other molecules, such as MAOB and PA, have no signal output because they cannot form close interaction with nanoparticles due to the existence of a CA layer. phenethylamine 98-100 monoamine oxidase B Homo sapiens 220-224 31556440-2 2019 This work measures a reduction in selectivity for the MAOB isoform of 3 to 9.5 kJ mol-1 upon the addition of hydroxy functional groups to a phenethylamine scaffold. phenethylamine 140-154 monoamine oxidase B Homo sapiens 54-58 33081086-1 2020 Monoamine oxidase B (MAOB) is expressed in the mitochondrial membrane and has a key role in degrading various neurologically active amines such as benzylamine, phenethylamine and dopamine with the help of Flavin adenine dinucleotide (FAD) cofactor. phenethylamine 160-174 monoamine oxidase B Homo sapiens 0-19 33081086-1 2020 Monoamine oxidase B (MAOB) is expressed in the mitochondrial membrane and has a key role in degrading various neurologically active amines such as benzylamine, phenethylamine and dopamine with the help of Flavin adenine dinucleotide (FAD) cofactor. phenethylamine 160-174 monoamine oxidase B Homo sapiens 21-25 31556440-3 2019 Replacement of hydroxy functional groups on the phenethylamine scaffold by hydrophobic substituents measures an increase in selectivity for MAOB of -1.1 to -6.9 kJ mol-1. phenethylamine 48-62 monoamine oxidase B Homo sapiens 140-144 29202379-5 2018 Platelet MAO-B activity was measured with 2-phenylethylamine (b-PEA) as substrate. phenethylamine 42-60 monoamine oxidase B Homo sapiens 9-14 31303592-2 2019 In this research paper, ligand based virtual screening has been performed in order to predict the inhibitors for monoamine oxidase (MAO-B), an enzyme specifically involved in the metabolism of non-hydroxylated amines such as benzylamine and beta-phenylethylamine (PEA), thus, could be the target to treat various neurodegenerative disorders like Parkinson"s disease. phenethylamine 241-262 monoamine oxidase B Homo sapiens 132-137 31303592-2 2019 In this research paper, ligand based virtual screening has been performed in order to predict the inhibitors for monoamine oxidase (MAO-B), an enzyme specifically involved in the metabolism of non-hydroxylated amines such as benzylamine and beta-phenylethylamine (PEA), thus, could be the target to treat various neurodegenerative disorders like Parkinson"s disease. phenethylamine 264-267 monoamine oxidase B Homo sapiens 132-137 20073575-7 2010 As shown by enzyme assays using [14C]serotonin or [14C]beta-phenylethylamine as selective MAO-A or MAO-B substrates, MAO-A is largely predominant in MSCs. phenethylamine 55-76 monoamine oxidase B Homo sapiens 99-104 25253656-3 2014 In this study we present a systematic study of the MAO-A and MAO-B substrate specificity profile by probing two series of phenethylamine analogs. phenethylamine 122-136 monoamine oxidase B Homo sapiens 61-66 20832472-4 2010 Incubation of MAO-B with 2-phenylethylamine, an endogenous trace amine and MAO-B substrate, resulted in a progressive loss of enzyme activity, increased enzyme mass, distinct spectral changes and, as was observed with tranylcypromine, a parallel increase in high affinity binding of [(3)H]2-BFI. phenethylamine 25-43 monoamine oxidase B Homo sapiens 14-19 20832472-4 2010 Incubation of MAO-B with 2-phenylethylamine, an endogenous trace amine and MAO-B substrate, resulted in a progressive loss of enzyme activity, increased enzyme mass, distinct spectral changes and, as was observed with tranylcypromine, a parallel increase in high affinity binding of [(3)H]2-BFI. phenethylamine 25-43 monoamine oxidase B Homo sapiens 75-80 20641293-2 2004 MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine. phenethylamine 97-111 monoamine oxidase B Homo sapiens 67-72 15569272-3 2004 Metabolism of 2-phenylethylamine to phenylacetaldehyde is catalysed by monoamine oxidase B but the oxidation to its acid is usually ascribed to aldehyde dehydrogenase and the contribution of aldehyde oxidase and xanthine oxidase, if any, is ignored. phenethylamine 14-32 monoamine oxidase B Homo sapiens 71-90 20642018-2 2004 MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine. phenethylamine 97-111 monoamine oxidase B Homo sapiens 67-72 20641420-2 2004 MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine. phenethylamine 97-111 monoamine oxidase B Homo sapiens 67-72 14697876-10 2004 MAO-A oxidizes noradrenaline and serotonin; and MAO-B, mainly beta-phenylethylamine. phenethylamine 62-83 monoamine oxidase B Homo sapiens 48-53 14628189-4 2003 Inhibition of monoamine-oxidase type B (MAO-B) and monoamine oxidase type A (MAO-A) activity was determined by measurement of as beta-phenylethylamine (PEA) by GCMS and 5-hydroxyindoleacetic acid (5-HIAA) by High Performance Liquid Chromatography (HPLC) assays. phenethylamine 129-150 monoamine oxidase B Homo sapiens 14-38 14628189-4 2003 Inhibition of monoamine-oxidase type B (MAO-B) and monoamine oxidase type A (MAO-A) activity was determined by measurement of as beta-phenylethylamine (PEA) by GCMS and 5-hydroxyindoleacetic acid (5-HIAA) by High Performance Liquid Chromatography (HPLC) assays. phenethylamine 152-155 monoamine oxidase B Homo sapiens 14-38 14628189-4 2003 Inhibition of monoamine-oxidase type B (MAO-B) and monoamine oxidase type A (MAO-A) activity was determined by measurement of as beta-phenylethylamine (PEA) by GCMS and 5-hydroxyindoleacetic acid (5-HIAA) by High Performance Liquid Chromatography (HPLC) assays. phenethylamine 152-155 monoamine oxidase B Homo sapiens 40-45 11797065-1 2001 RATIONALE AND OBJECTIVE: Sufficiently high doses of beta-phenylethylamine (beta-PEA), a trace amine that is rapidly metabolized by monoamine oxidase-type B (MAO-B), can produce effects comparable to those of cocaine or methamphetamine (MA). phenethylamine 52-73 monoamine oxidase B Homo sapiens 131-155 11797065-1 2001 RATIONALE AND OBJECTIVE: Sufficiently high doses of beta-phenylethylamine (beta-PEA), a trace amine that is rapidly metabolized by monoamine oxidase-type B (MAO-B), can produce effects comparable to those of cocaine or methamphetamine (MA). phenethylamine 52-73 monoamine oxidase B Homo sapiens 157-162 11797065-1 2001 RATIONALE AND OBJECTIVE: Sufficiently high doses of beta-phenylethylamine (beta-PEA), a trace amine that is rapidly metabolized by monoamine oxidase-type B (MAO-B), can produce effects comparable to those of cocaine or methamphetamine (MA). phenethylamine 75-83 monoamine oxidase B Homo sapiens 131-155 11797065-1 2001 RATIONALE AND OBJECTIVE: Sufficiently high doses of beta-phenylethylamine (beta-PEA), a trace amine that is rapidly metabolized by monoamine oxidase-type B (MAO-B), can produce effects comparable to those of cocaine or methamphetamine (MA). phenethylamine 75-83 monoamine oxidase B Homo sapiens 157-162 11134050-6 2001 The reciprocal mutant MAO B-Y326I exhibited an increased preference for 5-hydroxytryptamine, a decreased preference for beta-phenylethylamine, and, similar to MAO A, was more sensitive to clorgyline than to deprenyl. phenethylamine 120-141 monoamine oxidase B Homo sapiens 22-27 10936214-3 2000 When compared with MAO A, MAO A-F208I showed a sixfold decrease in the specificity constant k(cat)/K(m) for both the MAO A- and the MAO B-preferring substrates 5-hydroxytryptamine and beta-phenylethylamine, respectively. phenethylamine 184-205 monoamine oxidase B Homo sapiens 132-137 7721026-7 1994 MAO-B inhibitors can selectively and dramatically increase the level of beta-phenylethylamine, which has been shown to potentiate dopamine and noradrenaline function in the central nervous system. phenethylamine 72-93 monoamine oxidase B Homo sapiens 0-5 1759390-6 1991 After selective inhibition of MAO-A by chlorgyline the order of MAO-B-dependent effects of biogenic amines on mitochondrial enzymes studied was as follows: tyramine greater than or equal to 2-phenylethylamine much greater than serotonin. phenethylamine 190-208 monoamine oxidase B Homo sapiens 64-69 11134050-5 2001 Mutant MAO A-I335Y became like MAO B, which exhibits a higher preference for beta-phenylethylamine than for the MAO A preferred substrate serotonin (5-hydroxytryptamine), and became more sensitive to deprenyl (MAO B-specific inhibitor) than to clorgyline (MAO A-specific inhibitor). phenethylamine 77-98 monoamine oxidase B Homo sapiens 31-36 11160474-1 2001 OBJECTIVE: To evaluate the correlation between changes in platelet monoamine oxidase type B (MAO-B) activity and plasma beta-phenylethylamine (PEA) concentrations in patients with Parkinson"s disease and controls. phenethylamine 120-141 monoamine oxidase B Homo sapiens 67-91 11160474-1 2001 OBJECTIVE: To evaluate the correlation between changes in platelet monoamine oxidase type B (MAO-B) activity and plasma beta-phenylethylamine (PEA) concentrations in patients with Parkinson"s disease and controls. phenethylamine 120-141 monoamine oxidase B Homo sapiens 93-98 11160474-1 2001 OBJECTIVE: To evaluate the correlation between changes in platelet monoamine oxidase type B (MAO-B) activity and plasma beta-phenylethylamine (PEA) concentrations in patients with Parkinson"s disease and controls. phenethylamine 143-146 monoamine oxidase B Homo sapiens 67-91 11160474-1 2001 OBJECTIVE: To evaluate the correlation between changes in platelet monoamine oxidase type B (MAO-B) activity and plasma beta-phenylethylamine (PEA) concentrations in patients with Parkinson"s disease and controls. phenethylamine 143-146 monoamine oxidase B Homo sapiens 93-98 9503561-4 1997 MAO-A preferentially deaminates serotonin (5HT) and is selectively inhibited by harmine and clorgyline, while MAO-B preferentially deaminates phenethylamine and benzylamine, and is selectively inhibited by (-)deprenyl as well as low concentrations of pargyline. phenethylamine 142-156 monoamine oxidase B Homo sapiens 110-115 8847600-0 1995 SAR studies of fluorine-substituted benzylamines and substituted 2-phenylethylamines as substrates and inactivators of monoamine oxidase B. phenethylamine 65-84 monoamine oxidase B Homo sapiens 119-138 1609114-5 1992 In the central nervous system of man MAO-A seems to be mainly involved in the metabolism of 5 HT and noradrenaline, whereas 2-phenylethylamine and probably dopamine are predominantly deaminated by MAO-B. phenethylamine 124-142 monoamine oxidase B Homo sapiens 197-202