PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9711303-5	1998	When used at low concentrations, azide inhibited more than 70% of cytochrome oxidase (COX) activity without changes in bioenergetics (either lactate production or creatine phosphorylation) or mRNA for mitochondrial enzymes.	Azides	33-38	cytochrome c oxidase subunit 8A	Homo sapiens	66-84	
11796734-1	2002	Chronic treatment of cultured cells with very low levels of azide (I(50)<10 microm) leads to slow (t(12) = 6 h), irreversible loss of cytochrome c oxidase (COX) activity.	Azides	60-65	cytochrome c oxidase subunit 8A	Homo sapiens	159-162	
11796734-2	2002	Azide-mediated COX losses were not accompanied by inhibition of other mitochondrial enzymes and were not dependent upon electron flux through oxidative phosphorylation.	Azides	0-5	cytochrome c oxidase subunit 8A	Homo sapiens	15-18	
11796734-3	2002	Although azide treatment also reduced activity (but not content) of both CuZn superoxide dismutase and catalase, a spectrum of pro-oxidants (and anti-oxidants) failed to mimic (or prevent) azide effects, arguing that losses in COX activity were not due to resultant compromises in free radical scavenging.	Azides	9-14	cytochrome c oxidase subunit 8A	Homo sapiens	227-230	
11796734-7	2002	Differential azide effects on COX content relative to COX activity were confirmed using a refined inhibition time course in combination with blue native electrophoresis, and established that holoenzyme dissociation occurs subsequent to losses in catalytic activity.	Azides	13-18	cytochrome c oxidase subunit 8A	Homo sapiens	30-33	
9711303-5	1998	When used at low concentrations, azide inhibited more than 70% of cytochrome oxidase (COX) activity without changes in bioenergetics (either lactate production or creatine phosphorylation) or mRNA for mitochondrial enzymes.	Azides	33-38	cytochrome c oxidase subunit 8A	Homo sapiens	86-89	
9711303-6	1998	Higher azide concentrations resulted in changes in bioenergetic parameters and increases in steady state COX II mRNA levels.	Azides	7-12	cytochrome c oxidase subunit 8A	Homo sapiens	105-108