PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33852279-2 2021 We report here the design and development of the first amyloid-beta (Abeta)-targeted, blood-brain barrier (BBB) penetrable theranostic Gd(DOTA)-cyanine dyad, which was synthesized by the conjugation of Gd(DOTA) complex and carbazole-based cyanine dye by the copper(I)-catalyzed azide-alkyne cycloaddition click reaction for imaging of Abeta in vivo and ex vivo in AD mouse models. Azides 278-283 amyloid beta (A4) precursor protein Mus musculus 69-74 32110322-4 2019 Herein, we report that the accumulated Cu in Abeta plaques can effectively catalyze an azide-alkyne bioorthogonal cycloaddition reaction for fluorophore activation and drug synthesis in living cells, a transgenic AD model of Caenorhabditis elegans CL2006, and brain slices of triple transgenic AD mice. Azides 87-92 amyloid beta (A4) precursor protein Mus musculus 45-50