PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33915460-6	2021	Notably, the molecules containing furane substituent displayed higher inhibition against Mpro, followed by Ebselen 1i (IC50 = 0.074 muM) and Ebsulfur 2k (IC50 = 0.11 muM).	ebselen	107-114	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	89-93	
34031399-3	2021	An organoselenium drug called ebselen has been demonstrated to have potent Mpro inhibition and antiviral activity.	ebselen	30-37	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	75-79	
34031399-4	2021	We have examined the binding modes of ebselen and its derivative in Mpro via high resolution co-crystallography and investigated their chemical reactivity via mass spectrometry.	ebselen	38-45	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	68-72	
33400086-10	2022	The crystal structural and docking results have shown that Ebselen, N3, TDZD-8 and alpha-ketoamide (13b) inhibitors can bind to the substrate-binding pocket of COVID-19 Mpro.	ebselen	59-66	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	169-173	
34575955-1	2021	The inhibition mechanism of the main protease (Mpro) of SARS-CoV-2 by ebselen (EBS) and its analog with a hydroxyl group at position 2 of the benzisoselenazol-3(2H)-one ring (EBS-OH) was studied by using a density functional level of theory.	ebselen	70-77	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	47-51	
32911432-6	2020	Here, our aim was to investigate small molecules, including lopinavir and ritonavir, alpha-ketoamide 13b, and ebselen, for their ability to interact with the Mpro.	ebselen	110-117	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	158-162	
34575955-3	2021	The potential energy surfaces for the formation of the Se-S covalent bond mediated by EBS and EBS-OH on Mpro are discussed in detail.	ebselen	86-89	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	104-108	
34575955-3	2021	The potential energy surfaces for the formation of the Se-S covalent bond mediated by EBS and EBS-OH on Mpro are discussed in detail.	ebselen	94-97	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	104-108	
34575955-6	2021	The knowledge of the inhibition mechanism of Mpro by the small protease inhibitors EBS or EBS-OH can enlarge the possibilities for designing more potent and selective inhibitor-based drugs to be used in combination with other antiviral therapies.	ebselen	83-86	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	45-49	
32598985-7	2020	In further research on the inhibition of Mpro in SARS-CoV-2, ebselen can serve as a promising lead compound, if the inhibitory effect is confirmed in intact cells in vivo.	ebselen	61-68	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	41-45	
34575955-1	2021	The inhibition mechanism of the main protease (Mpro) of SARS-CoV-2 by ebselen (EBS) and its analog with a hydroxyl group at position 2 of the benzisoselenazol-3(2H)-one ring (EBS-OH) was studied by using a density functional level of theory.	ebselen	79-82	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	47-51