PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17045269-6 2007 Cyanidin also ameliorated TNF-alpha-induced decrease of Trx S-nitrosylation and intracellular glutathione and elevation of 4-hydroxynonenal (4-HNE), a major aldehydic product of lipid peroxidation. 4-hydroxy-2-nonenal 141-146 tumor necrosis factor Homo sapiens 26-35 17045269-6 2007 Cyanidin also ameliorated TNF-alpha-induced decrease of Trx S-nitrosylation and intracellular glutathione and elevation of 4-hydroxynonenal (4-HNE), a major aldehydic product of lipid peroxidation. 4-hydroxy-2-nonenal 123-139 tumor necrosis factor Homo sapiens 26-35 18772336-1 2008 The compound 4-hydroxynonenal (4-HNE) is the major aldehyde formed during lipid peroxidation of omega-6-polyunsaturated fatty acids and has been suggested to regulate inflammatory responses because it inhibits tumor necrosis factor (TNF) mRNA production in the human monocytic cell line THP-1. 4-hydroxy-2-nonenal 13-29 tumor necrosis factor Homo sapiens 210-231 18772336-1 2008 The compound 4-hydroxynonenal (4-HNE) is the major aldehyde formed during lipid peroxidation of omega-6-polyunsaturated fatty acids and has been suggested to regulate inflammatory responses because it inhibits tumor necrosis factor (TNF) mRNA production in the human monocytic cell line THP-1. 4-hydroxy-2-nonenal 13-29 tumor necrosis factor Homo sapiens 233-236 18772336-1 2008 The compound 4-hydroxynonenal (4-HNE) is the major aldehyde formed during lipid peroxidation of omega-6-polyunsaturated fatty acids and has been suggested to regulate inflammatory responses because it inhibits tumor necrosis factor (TNF) mRNA production in the human monocytic cell line THP-1. 4-hydroxy-2-nonenal 31-36 tumor necrosis factor Homo sapiens 210-231 18772336-1 2008 The compound 4-hydroxynonenal (4-HNE) is the major aldehyde formed during lipid peroxidation of omega-6-polyunsaturated fatty acids and has been suggested to regulate inflammatory responses because it inhibits tumor necrosis factor (TNF) mRNA production in the human monocytic cell line THP-1. 4-hydroxy-2-nonenal 31-36 tumor necrosis factor Homo sapiens 233-236 18772336-2 2008 Here we demonstrate that 4-HNE inhibits TNF and interleukin-1beta production in human monocytes in response to lipopolysaccharide. 4-hydroxy-2-nonenal 25-30 tumor necrosis factor Homo sapiens 40-43 11500179-2 2001 This study extends these findings by investigating the effect of three aldehydes (2,4-decadienal (2,4-DDE), hexanal and 4-hydroxynonenal (4-HNE)) on TNF-alpha and IL-1beta mRNA expression. 4-hydroxy-2-nonenal 120-136 tumor necrosis factor Homo sapiens 149-158 11500179-2 2001 This study extends these findings by investigating the effect of three aldehydes (2,4-decadienal (2,4-DDE), hexanal and 4-hydroxynonenal (4-HNE)) on TNF-alpha and IL-1beta mRNA expression. 4-hydroxy-2-nonenal 138-143 tumor necrosis factor Homo sapiens 149-158 10206970-0 1999 4-Hydroxynonenal prevents NF-kappaB activation and tumor necrosis factor expression by inhibiting IkappaB phosphorylation and subsequent proteolysis. 4-hydroxy-2-nonenal 0-16 tumor necrosis factor Homo sapiens 51-72 27164408-0 2016 4-Hydroxynonenal Regulates TNF-alpha Gene Transcription Indirectly via ETS1 and microRNA-29b in Human Adipocytes Induced From Adipose Tissue-Derived Stromal Cells. 4-hydroxy-2-nonenal 0-16 tumor necrosis factor Homo sapiens 27-36 27164408-13 2016 In addition, we demonstrated that 4-HNE promotes TNF-alpha gene transcription through the inhibition of the miR-29b SP1 TNF-alpha pathway and promotion of the ETS1 TNF-alpha pathway. 4-hydroxy-2-nonenal 34-39 tumor necrosis factor Homo sapiens 49-58 27164408-13 2016 In addition, we demonstrated that 4-HNE promotes TNF-alpha gene transcription through the inhibition of the miR-29b SP1 TNF-alpha pathway and promotion of the ETS1 TNF-alpha pathway. 4-hydroxy-2-nonenal 34-39 tumor necrosis factor Homo sapiens 124-133 27164408-13 2016 In addition, we demonstrated that 4-HNE promotes TNF-alpha gene transcription through the inhibition of the miR-29b SP1 TNF-alpha pathway and promotion of the ETS1 TNF-alpha pathway. 4-hydroxy-2-nonenal 34-39 tumor necrosis factor Homo sapiens 124-133 26970310-4 2016 Furthermore, a knockdown of MTA1 by siRNA in the human fibroblast-like synovial cell line MH7A was found to impair the 4-hydroxynonenal (4-HNE)-induced transcriptional expression levels of certain proinflammatory cytokines including IL-1beta, TNF-alpha and IL-6. 4-hydroxy-2-nonenal 119-135 tumor necrosis factor Homo sapiens 243-252