PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17045269-6	2007	Cyanidin also ameliorated TNF-alpha-induced decrease of Trx S-nitrosylation and intracellular glutathione and elevation of 4-hydroxynonenal (4-HNE), a major aldehydic product of lipid peroxidation.	4-hydroxy-2-nonenal	141-146	tumor necrosis factor	Homo sapiens	26-35	
17045269-6	2007	Cyanidin also ameliorated TNF-alpha-induced decrease of Trx S-nitrosylation and intracellular glutathione and elevation of 4-hydroxynonenal (4-HNE), a major aldehydic product of lipid peroxidation.	4-hydroxy-2-nonenal	123-139	tumor necrosis factor	Homo sapiens	26-35	
18772336-1	2008	The compound 4-hydroxynonenal (4-HNE) is the major aldehyde formed during lipid peroxidation of omega-6-polyunsaturated fatty acids and has been suggested to regulate inflammatory responses because it inhibits tumor necrosis factor (TNF) mRNA production in the human monocytic cell line THP-1.	4-hydroxy-2-nonenal	13-29	tumor necrosis factor	Homo sapiens	210-231	
18772336-1	2008	The compound 4-hydroxynonenal (4-HNE) is the major aldehyde formed during lipid peroxidation of omega-6-polyunsaturated fatty acids and has been suggested to regulate inflammatory responses because it inhibits tumor necrosis factor (TNF) mRNA production in the human monocytic cell line THP-1.	4-hydroxy-2-nonenal	13-29	tumor necrosis factor	Homo sapiens	233-236	
18772336-1	2008	The compound 4-hydroxynonenal (4-HNE) is the major aldehyde formed during lipid peroxidation of omega-6-polyunsaturated fatty acids and has been suggested to regulate inflammatory responses because it inhibits tumor necrosis factor (TNF) mRNA production in the human monocytic cell line THP-1.	4-hydroxy-2-nonenal	31-36	tumor necrosis factor	Homo sapiens	210-231	
18772336-1	2008	The compound 4-hydroxynonenal (4-HNE) is the major aldehyde formed during lipid peroxidation of omega-6-polyunsaturated fatty acids and has been suggested to regulate inflammatory responses because it inhibits tumor necrosis factor (TNF) mRNA production in the human monocytic cell line THP-1.	4-hydroxy-2-nonenal	31-36	tumor necrosis factor	Homo sapiens	233-236	
18772336-2	2008	Here we demonstrate that 4-HNE inhibits TNF and interleukin-1beta production in human monocytes in response to lipopolysaccharide.	4-hydroxy-2-nonenal	25-30	tumor necrosis factor	Homo sapiens	40-43	
11500179-2	2001	This study extends these findings by investigating the effect of three aldehydes (2,4-decadienal (2,4-DDE), hexanal and 4-hydroxynonenal (4-HNE)) on TNF-alpha and IL-1beta mRNA expression.	4-hydroxy-2-nonenal	120-136	tumor necrosis factor	Homo sapiens	149-158	
11500179-2	2001	This study extends these findings by investigating the effect of three aldehydes (2,4-decadienal (2,4-DDE), hexanal and 4-hydroxynonenal (4-HNE)) on TNF-alpha and IL-1beta mRNA expression.	4-hydroxy-2-nonenal	138-143	tumor necrosis factor	Homo sapiens	149-158	
10206970-0	1999	4-Hydroxynonenal prevents NF-kappaB activation and tumor necrosis factor expression by inhibiting IkappaB phosphorylation and subsequent proteolysis.	4-hydroxy-2-nonenal	0-16	tumor necrosis factor	Homo sapiens	51-72	
27164408-0	2016	4-Hydroxynonenal Regulates TNF-alpha Gene Transcription Indirectly via ETS1 and microRNA-29b in Human Adipocytes Induced From Adipose Tissue-Derived Stromal Cells.	4-hydroxy-2-nonenal	0-16	tumor necrosis factor	Homo sapiens	27-36	
27164408-13	2016	In addition, we demonstrated that 4-HNE promotes TNF-alpha gene transcription through the inhibition of the miR-29b   SP1   TNF-alpha pathway and promotion of the ETS1   TNF-alpha pathway.	4-hydroxy-2-nonenal	34-39	tumor necrosis factor	Homo sapiens	49-58	
27164408-13	2016	In addition, we demonstrated that 4-HNE promotes TNF-alpha gene transcription through the inhibition of the miR-29b   SP1   TNF-alpha pathway and promotion of the ETS1   TNF-alpha pathway.	4-hydroxy-2-nonenal	34-39	tumor necrosis factor	Homo sapiens	124-133	
27164408-13	2016	In addition, we demonstrated that 4-HNE promotes TNF-alpha gene transcription through the inhibition of the miR-29b   SP1   TNF-alpha pathway and promotion of the ETS1   TNF-alpha pathway.	4-hydroxy-2-nonenal	34-39	tumor necrosis factor	Homo sapiens	124-133	
26970310-4	2016	Furthermore, a knockdown of MTA1 by siRNA in the human fibroblast-like synovial cell line MH7A was found to impair the 4-hydroxynonenal (4-HNE)-induced transcriptional expression levels of certain proinflammatory cytokines including IL-1beta, TNF-alpha and IL-6.	4-hydroxy-2-nonenal	119-135	tumor necrosis factor	Homo sapiens	243-252