PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21222511-2	2011	Structure-activity relationship study suggested that inhibitory activity against BACE1 was governed to a greater extent by the hydroxyl substituent on A- and B-ring of the chalcone, and the most active compound was substituted with four hydroxyl group (17, IC(50) = 0.27 muM).	Hydroxyl Radical	127-135	beta-secretase 1	Homo sapiens	81-86	
21222511-2	2011	Structure-activity relationship study suggested that inhibitory activity against BACE1 was governed to a greater extent by the hydroxyl substituent on A- and B-ring of the chalcone, and the most active compound was substituted with four hydroxyl group (17, IC(50) = 0.27 muM).	Hydroxyl Radical	237-245	beta-secretase 1	Homo sapiens	81-86	
19576765-1	2009	Two series of drug-like BACE-1 inhibitors with a shielded tertiary hydroxyl as transition state isostere have been synthesized.	Hydroxyl Radical	67-75	beta-secretase 1	Homo sapiens	24-30