PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34563253-0 2021 AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation. tetramethylenedisulfotetramine 82-85 thymoma viral proto-oncogene 1 Mus musculus 0-3 34563253-4 2021 Here we report a line of evidence that supports the notion that AKT signaling is involved in TET-mediated DNA demethylation during iPSC induction. tetramethylenedisulfotetramine 93-96 thymoma viral proto-oncogene 1 Mus musculus 64-67 34563253-12 2021 CONCLUSION: These results suggest the possibility that the activation of AKT during somatic cell reprogramming promotes epigenetic reprogramming through the hyperactivation of TET at the transcriptional and catalytic levels. tetramethylenedisulfotetramine 176-179 thymoma viral proto-oncogene 1 Mus musculus 73-76 28481866-7 2017 The Tet-On induction of MadMyc in preneoplastic cells significantly inhibited the progression of AKT/HRAS-induced tumours; its induction in transformed cells suppressed their proliferative activity with alterations in lipid metabolism and protein translation. tetramethylenedisulfotetramine 4-7 thymoma viral proto-oncogene 1 Mus musculus 97-100