PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18799678-2 2008 Using a rat model of cerebral ischemia without recirculation, we tested whether ischemia enhances the activation by Ca2+ of ryanodine receptor (RyR) channels, a requisite feature of RyR-mediated Ca2+-induced Ca2+ release (CICR). cicr 222-226 ryanodine receptor 2 Rattus norvegicus 144-147 29574066-4 2018 Blockade of the ryanodine receptor (RyR) and of Ca2+ release from the sarcoplasmic reticulum (SR) markedly reduced depolarization-induced Ca2+ responses in arteries from lean but not obese rats, suggesting impaired Ca2+-induced Ca2+ release (CICR) from SR in arteries from OZR. cicr 242-246 ryanodine receptor 2 Rattus norvegicus 16-34 22073362-9 2009 This increase of [Ca(2+)]i induced by ACh was caused by not only the calcium influx through surface calcium channels, but also the calciuminduced calcium release (CICR) from intracellular RyR-sensitive calcium stores. cicr 163-167 ryanodine receptor 2 Rattus norvegicus 188-191 23708355-3 2013 The termination of CICR by induction decay in the model principally arose from the steep Ca(2+) dependence of RyR closed time, with the measured sarcoplasmic reticulum (SR) lumen Ca(2+) dependence of RyR gating making almost no contribution. cicr 19-23 ryanodine receptor 2 Rattus norvegicus 110-113 23708355-3 2013 The termination of CICR by induction decay in the model principally arose from the steep Ca(2+) dependence of RyR closed time, with the measured sarcoplasmic reticulum (SR) lumen Ca(2+) dependence of RyR gating making almost no contribution. cicr 19-23 ryanodine receptor 2 Rattus norvegicus 200-203 18799678-2 2008 Using a rat model of cerebral ischemia without recirculation, we tested whether ischemia enhances the activation by Ca2+ of ryanodine receptor (RyR) channels, a requisite feature of RyR-mediated Ca2+-induced Ca2+ release (CICR). cicr 222-226 ryanodine receptor 2 Rattus norvegicus 182-185 18799678-11 2008 We propose that ischemia, by enhancing RyR2 S-glutathionylation, allows RyR2 to sustain CICR; the resulting amplification of Ca2+ entry signals may contribute to cortical neuronal death. cicr 88-92 ryanodine receptor 2 Rattus norvegicus 39-43 18799678-11 2008 We propose that ischemia, by enhancing RyR2 S-glutathionylation, allows RyR2 to sustain CICR; the resulting amplification of Ca2+ entry signals may contribute to cortical neuronal death. cicr 88-92 ryanodine receptor 2 Rattus norvegicus 72-76 15979854-2 2005 The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) and the ryanodine (Ry) receptor (RyR) are involved in Ca(2+)-induced Ca(2+)-release (CICR). cicr 140-144 ryanodine receptor 2 Rattus norvegicus 88-91 17719086-2 2008 Here, we identify an ionotropic glutamate receptor signal transduction pathway which invokes RyR-gated Ca2+ stores in SGN via Ca2+-induced Ca2+ release (CICR). cicr 153-157 ryanodine receptor 2 Rattus norvegicus 93-96 17719086-6 2008 Ca2+ influx via the glutamate receptor was found to elicit CICR via RyR-gated Ca2+ stores, as shown by the inhibition of the response by prior depletion of the Ca2+ stores with caffeine, the SERCA inhibitor thapsigargin, or ryanodine. cicr 59-63 ryanodine receptor 2 Rattus norvegicus 68-71 17360812-1 2007 Despite their relevance for neuronal Ca(2+)-induced Ca(2+) release (CICR), activation by Ca(2+) of ryanodine receptor (RyR) channels of brain endoplasmic reticulum at the [ATP], [Mg(2+)], and redox conditions present in neurons has not been reported. cicr 68-72 ryanodine receptor 2 Rattus norvegicus 119-122 17360812-9 2007 If RyR behave similarly in living neurons, cellular redox state should affect RyR-mediated CICR. cicr 91-95 ryanodine receptor 2 Rattus norvegicus 3-6 17360812-9 2007 If RyR behave similarly in living neurons, cellular redox state should affect RyR-mediated CICR. cicr 91-95 ryanodine receptor 2 Rattus norvegicus 78-81 15979854-4 2005 We investigated the RyR-associated effects of CICR agents on basal and K(+)-evoked releases of GABA and glutamate in rat hippocampus and the changes in expression of mRNA for RyRs in mouse brain after KA-induced seizures. cicr 46-50 ryanodine receptor 2 Rattus norvegicus 20-23 15979854-6 2005 The inflection point in concentration-response curves for Ry on GABA release was lower than that for glutamate in both basal and K(+)-evoked conditions, suggesting that hyperactivation of RyR-associated CICR produces the imbalance between GABAergic and glutamatergic transmission. cicr 203-207 ryanodine receptor 2 Rattus norvegicus 188-191 14699012-3 2004 Physiological concentrations of cytosolic NADH inhibited ryanodine receptor type 2 (RyR2)-mediated Ca2+-induced Ca2+ release (CICR) from SR membranes (IC50=120 micromol/L) and significantly lowered single channel open probability. cicr 126-130 ryanodine receptor 2 Rattus norvegicus 84-88 15452201-13 2004 Reducing [Mg2+] below 2 mM, which should enable the RyR channel"s activation (CICR) site to bind Ca2+, caused progressive increase in spark frequency in the frog, but had no effect in the rat. cicr 78-82 ryanodine receptor 2 Rattus norvegicus 52-55 15598842-2 2005 The Ca(2+) signal is augmented by calcium-induced calcium release (CICR) and by cyclic adeninediphosphate ribose (cADPR), which sensitizes the ryanodine-sensitive receptor (RyR) to Ca(2+) to further amplify CICR. cicr 207-211 ryanodine receptor 2 Rattus norvegicus 173-176 12215490-9 2002 We conclude that regulation of RyR openings by local intra-SR [Ca2+] is responsible for termination of CICR and for the subsequent restitution behavior of Ca2+ release sites in cardiac muscle. cicr 103-107 ryanodine receptor 2 Rattus norvegicus 31-34 9147322-3 1997 This study was intended to examine whether FK506-binding protein (FKBP), which is tightly associated to the ryanodine receptor (RyR)/Ca2+ release channel, plays a role in the termination of Ca(2+)-induced Ca2+ release (CICR) in heart. cicr 219-223 ryanodine receptor 2 Rattus norvegicus 108-126 9147322-3 1997 This study was intended to examine whether FK506-binding protein (FKBP), which is tightly associated to the ryanodine receptor (RyR)/Ca2+ release channel, plays a role in the termination of Ca(2+)-induced Ca2+ release (CICR) in heart. cicr 219-223 ryanodine receptor 2 Rattus norvegicus 128-131