PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27236015-0 2016 Synthesis and biological evaluation of novel 4-hydroxytamoxifen analogs as estrogen-related receptor gamma inverse agonists. hydroxytamoxifen 45-63 estrogen related receptor gamma Homo sapiens 75-106 27805390-0 2016 Insights of a Lead Optimization Study and Biological Evaluation of Novel 4-Hydroxytamoxifen Analogs as Estrogen-Related Receptor gamma (ERRgamma) Inverse Agonists. hydroxytamoxifen 73-91 estrogen related receptor gamma Homo sapiens 103-134 27805390-0 2016 Insights of a Lead Optimization Study and Biological Evaluation of Novel 4-Hydroxytamoxifen Analogs as Estrogen-Related Receptor gamma (ERRgamma) Inverse Agonists. hydroxytamoxifen 73-91 estrogen related receptor gamma Homo sapiens 136-144 20542892-0 2010 Distinction of the binding modes for human nuclear receptor ERRgamma between bisphenol A and 4-hydroxytamoxifen. hydroxytamoxifen 93-111 estrogen related receptor gamma Homo sapiens 60-68 21056663-2 2011 The synthetic estrogen receptor ligands 4-hydroxytamoxifen and diethylstilbestrol have, however, been shown to bind to and abolish the constitutive transcriptional activity of ERRgamma. hydroxytamoxifen 40-58 estrogen related receptor gamma Homo sapiens 176-184 20542892-3 2010 BPA functions as an inverse-type antagonist of ERRgamma to retain its high basal constitutive activity by inhibiting the deactivating inverse agonist activity of 4-hydroxytamoxifen (4-OHT). hydroxytamoxifen 162-180 estrogen related receptor gamma Homo sapiens 47-55 17964775-4 2008 These ligands were further characterized and found to be competitive for 4-hydroxytamoxifen (4OHT) binding, a known reported antagonist ligand for ERRgamma, but functionally they did not enhance or disrupt affinity of the receptor for co-activator peptides. hydroxytamoxifen 73-91 estrogen related receptor gamma Homo sapiens 147-155 18974135-6 2008 Selection for resistance to 4-hydroxytamoxifen led to the development of the SUM44/LCCTam cell line, which exhibits decreased expression of ERalpha and increased expression of the estrogen-related receptor gamma (ERRgamma). hydroxytamoxifen 28-46 estrogen related receptor gamma Homo sapiens 180-211 18974135-6 2008 Selection for resistance to 4-hydroxytamoxifen led to the development of the SUM44/LCCTam cell line, which exhibits decreased expression of ERalpha and increased expression of the estrogen-related receptor gamma (ERRgamma). hydroxytamoxifen 28-46 estrogen related receptor gamma Homo sapiens 213-221 18197296-2 2008 We have recently demonstrated that BPA binds strongly to human estrogen-related receptor-gamma (ERR-gamma ) in a binding assay using [3H]4-hydroxytamoxifen ([3H]4-OHT). hydroxytamoxifen 137-155 estrogen related receptor gamma Homo sapiens 63-94 18197296-2 2008 We have recently demonstrated that BPA binds strongly to human estrogen-related receptor-gamma (ERR-gamma ) in a binding assay using [3H]4-hydroxytamoxifen ([3H]4-OHT). hydroxytamoxifen 137-155 estrogen related receptor gamma Homo sapiens 96-105 18005256-4 2007 Bisphenol A functions as an inverse antagonist of estrogen-related receptor gamma to sustain the high basal constitutive activity of the latter and to reverse the deactivating inverse agonist activity of 4-hydroxytamoxifen. hydroxytamoxifen 204-222 estrogen related receptor gamma Homo sapiens 50-81 14751226-2 2004 However, 4-hydroxytamoxifen and diethylstilbestrol were recently shown to bind to and inhibit ERRgamma activity. hydroxytamoxifen 9-27 estrogen related receptor gamma Homo sapiens 94-102 17761695-4 2007 BPA preserves the ERR gamma"s basal constitutive activity, and protects the selective ER modulator 4-hydroxytamoxifen from its deactivation of ERR gamma. hydroxytamoxifen 99-117 estrogen related receptor gamma Homo sapiens 143-152 16889744-2 2006 Although its physiological ligand is unknown, ERRgamma has been shown to interact with synthetic estrogenic compounds such as 4-hydroxytamoxifen (4-OHT), tamoxifen, and diethylstilbestrol (DES). hydroxytamoxifen 126-144 estrogen related receptor gamma Homo sapiens 46-54 16515477-10 2006 The selective estrogen receptor modulators 4-hydroxytamoxifen and 4-hydroxytoremifene antagonize ERRgamma. hydroxytamoxifen 43-61 estrogen related receptor gamma Homo sapiens 97-105 15161930-0 2004 Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity. hydroxytamoxifen 102-120 estrogen related receptor gamma Homo sapiens 45-76 15161930-2 2004 Although no natural ligand is known, ERRgamma is deactivated by the estrogen receptor (ER) agonist diethylstilbestrol and the selective ER modulator 4-hydroxytamoxifen but does not significantly respond to estradiol or raloxifene. hydroxytamoxifen 149-167 estrogen related receptor gamma Homo sapiens 37-45 15161930-3 2004 Here we report the crystal structures of the ERRgamma ligand binding domain (LBD) complexed with diethylstilbestrol or 4-hydroxytamoxifen. hydroxytamoxifen 119-137 estrogen related receptor gamma Homo sapiens 45-53 15161930-7 2004 Comparison of the ligand-bound LBDs of ERRgamma and ERalpha reveals small but significant differences in the architecture of the ligand binding pockets that result in a slightly shifted binding position of diethylstilbestrol and a small rotation of 4-hydroxytamoxifen in the cavity of ERRgamma relative to ERalpha. hydroxytamoxifen 249-267 estrogen related receptor gamma Homo sapiens 39-47 15161930-7 2004 Comparison of the ligand-bound LBDs of ERRgamma and ERalpha reveals small but significant differences in the architecture of the ligand binding pockets that result in a slightly shifted binding position of diethylstilbestrol and a small rotation of 4-hydroxytamoxifen in the cavity of ERRgamma relative to ERalpha. hydroxytamoxifen 249-267 estrogen related receptor gamma Homo sapiens 285-293 11447273-0 2001 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma. hydroxytamoxifen 0-18 estrogen related receptor gamma Homo sapiens 48-79 11447273-2 2001 By using a peptide sensor assay, we have identified the stilbenes diethylstilbestrol (DES), tamoxifen (TAM), and 4-hydroxytamoxifen (4-OHT) as high-affinity ligands for ERR gamma. hydroxytamoxifen 113-131 estrogen related receptor gamma Homo sapiens 169-178